La sculpture funéraire à Marseille aux IVe et Ve siècles

Drocourt Daniel, Drocourt Geneviève. La sculpture funéraire à Marseille aux IVe et Ve siècles. In: Bulletin Monumental, tome 132, n°2, année 1974. pp. 147-153

Deux chapiteaux inédits du cloître de l'abbaye Saint-Victor de Marseille

Drocourt Daniel, Drocourt Geneviève. Deux chapiteaux inédits du cloître de l'abbaye Saint-Victor de Marseille. In: Bulletin Monumental, tome 131, n°2, année 1973. pp. 155-159

Le voûtement de la nef raymondine de la cathédrale de Toulouse

Drocourt Daniel. Le voûtement de la nef raymondine de la cathédrale de Toulouse. In: La naissance et l'essor du gothique méridional. Toulouse : Éditions Privat, 1974. pp. 55-70. (Cahiers de Fanjeaux, 9

I. Le lavabo du cloître de Saint-Victor de Marseille

Drocourt Daniel. I. Le lavabo du cloître de Saint-Victor de Marseille. In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 82, N°97, 1970. pp. 181-182

D'où provient l'épitaphe de Volusianus?

Drocourt D., Marrou Henri-Irénée. D'où provient l'épitaphe de Volusianus?. In: Christiana tempora. Mélanges d'histoire, d'archéologie, d'épigraphie et de patristique. Rome : École Française de Rome, 1978. pp. 119-128. (Publications de l'École française de Rome, 35

D'où provient l'épitaphe de Volusianus?

Drocourt D., Marrou Henri-Irénée. D'où provient l'épitaphe de Volusianus?. In: Christiana tempora. Mélanges d'histoire, d'archéologie, d'épigraphie et de patristique. Rome : École Française de Rome, 1978. pp. 119-128. (Publications de l'École française de Rome, 35

Byzantium and Scandinavia

Föller D. Byzantium and Scandinavia. In: Kolditz S, Drocourt N, eds. A Companion to Byzantium and the West, 900–1204. Brill Companions to the Byzantine World. Vol 10. 1st ed. Leiden: Brill; 2022: 273-299

Innate immune response of alveolar macrophage to house dust mite allergen is mediated through TLR2/-4 co-activation.

House dust mite, Dermatophagoides pteronyssinus (Der p), is one of the major allergens responsible for allergic asthma. However, the putative receptors involved in the signalization of Der p to the innate immune cells are still poorly defined as well as the impact of their activation on the outcome of the allergen-induced cell response. We previously reported that the HDM activation of mouse alveolar macrophages (AM) involves the TLR4/CD14 cell surface receptor complex. Here using a TLR ligand screening essay, we demonstrate that HDM protein extract engages the TLR2, in addition to the TLR4, in engineered TLR-transfected HEK cells but also in the MH-S mouse alveolar macrophage cell line model. Moreover we found that the concomitant recruitment of the MH-S cell's TLR2 and TLR4 receptors by the HDM extract activates the MyD88-dependent signaling pathway and leads to the secretion of the NF-κB regulated pro-inflammatory factors NO and TNF-α. However unlike with the canonical TLR4 ligand (i.e. the bacterial LPS) mobilization of TLR4 by the HDM extract induces a reduced production of the IL-12 pro-inflammatory cytokine and fails to trigger the expression of the T-bet transcription factor. Finally we demonstrated that HDM extract down-regulates LPS induced IL-12 and T-bet expression through a TLR2 dependent mechanism. Therefore, we propose that the simultaneous engagement of the TLR2 and TLR4 receptors by the HDM extract results in a cross regulated original activation pattern of the AM which may contribute to the Th2 polarization of the allergen-induced immune response. The deciphering of these cross-regulation networks is of prime importance to open the way for original therapeutic strategies taking advantage of these receptors and their associated signaling pathways to treat allergic asthma