Réflexions sur l’intégration du numérique dans l’enseignement/apprentissage du FLE : enjeux d’une évolution pédagogique

Résumé: C’est évident que l’évolution du numérique interpelle au fur et à mesure la didactique du FLE. Les supports multimédias et les outils numériques ont rendu l’apprentissage des langues étrangères plus facile et intéressant. Beaucoup de travaux affirment que l’usage du numérique présente de nombreux avantages et enjeux en même temps.  Ce travail vise à montrer que l’intégration de pratiques innovantes du numérique pourrait devenir opérationnel tout en soulignant l'utilité des dispositifs innovants dans l’enseignement/apprentissage du FLE. L’objectif principal est d’exposer comment les nouvelles technologies sont rentrées et se sont imposées dans le domaine de didactique des langues et quels sont les moyens effectifs de les intégrer en classe de FLE. Mots-clés : ère numérique, didactique des langues, plateforme, multimédi

EFFECT OF DIETARY ZINC, COPPER AND IRON LEVELS ON SUPEROXIDE DISMUTASE, CATALASE AND GLUTATHIONE-S- TRANSFERASE ACTIVITY

The interactions between dietary zinc, copper and iron and their effects on antioxidant enzymes activity [superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST)] were examined. Fifty-four rats weighting approximately between 80-100 grams were divided into nine groups (E1- E9). Each group containing six rats was fed on basal diet with varying amount of Zn (2.5, 35 or 175 mg Zn/kg diet), Cu (1.2, 6.3, or 25 mg Cu/kg diet) and Fe (10, 50 or 230 mg Fe/kg diet). The second group (E2) was fed a diet defi-cient in all studied elements (2.5mg Zn, 1.2mg Cu, and 10mg Fe per 1 kg diet). The results of E2 showed a decrease in SOD and CAT activity and increase GST in plasma erythrocytes and tissues. Moreover, plasma thiobarbituric acid reactive sub-stances (TBARs) and hydrogen peroxide produc-tion in E2 were found to be higher than those in other groups. The high activity of lactic acid de-hydrogenase (LDH) in the plasma indicated that cell membrane damage was occurred. This dam-age was accompanied by elevation of lipid peroxi-dation and in the same time by reduction of SOD and CAT activity. Supplementation of basal diet with the different concentrations of studied miner-als led to improve the activity of antioxidants en-zymes (SOD and CAT) and decrease in TBARs and LDH activity

Effect of l-Arginine on Human Coronary Endothelium-Dependent and Physiologic Vasodilation

AbstractObjectives. We hypothesized that l-arginine would improve abnormal coronary vasodilation in response to physiologic stress in patients with atherosclerosis and its risk factors by reversing coronary endothelial dysfunction.Background. Studies have demonstrated that physiologic coronary vasodilation correlates with endothelial function and that l-arginine, the substrate for nitric oxide synthesis, improves the response to acetylcholine (Ach).Methods. Changes in coronary blood flow and epicardial diameter response to Ach, adenosine and cardiac pacing were measured in 32 patients with coronary atherosclerosis or its risk factors and in 7 patients without risk factors and normal coronary angiograms.Results. Intracoronary l-arginine did not alter baseline coronary vascular tone, but the epicardial and microvascular responses to Ach were enhanced (both p < 0.001). The improvement after l-arginine was greater in epicardial segments that initially constricted with Ach; similarly, l-arginine abolished microvascular constriction produced by higher doses of Ach. Thus, there was a negative correlation between the initial epicardial and vascular resistance responses to Ach and the magnitude of improvement with l-arginine (r = −0.55 and r = −0.50, respectively, p < 0.001). d-Arginine did not affect the responses to Ach, and adenosine responses were unchanged with l-arginine. Cardiac pacing-induced epicardial constriction was abolished by l-arginine, but microvascular dilation remained unaffected.Conclusions. Thus, l-arginine improved endothelium-dependent coronary epicardial and microvascular function in patients with endothelial dysfunction. Prevention of epicardial constriction during physiologic stress by l-arginine in patients with endothelial dysfunction may be of therapeutic value in the treatment of myocardial ischemia

PROTECTIVE EFFECT OF FOLIC ACID AGAINST H2O2 INDUCED-HEPATIC OXIDATIVE STRESS IN AGED RATS

The protective effect of folic acid (FA) on he-patic oxidative stress in aged rats exposed to oxi-dative stress by supply drinking water with 1% H2O2 (v/v) was studied. Rats were divided into two groups, the first group was considered as standard one (F1) which was fed on basal diet and administrated 1 mg FA/ Kg body weight (BW) daily by stomach tube without addition H2O2 in drinking water. The second group was divided into five subgroups, the first subgroup was the control (F2) which fed on basal diet free from folic acid (FF) with 1 % H2O2 in the drinking water, while other groups from F3 to F6 were adminis-trated different concentrations of folic acid (1, 20, 40 and 80 mg FA/ Kg BW), respectively. Weight gain, total feed intake, feed efficiency, liver weight and its relative weight were estimated. Bi-ochemical assay: activity of antioxidant enzymes system such as superoxide dismutase (SOD), cata-lase (CAT); lipid peroxidation level as malondial-dehyde (MDA), hydrogen peroxidase (H2O2); and liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phos-phatase (ALP) and gamma glutamyl transferase (γ-GT), and lactate dehydrogenase (LDH)], were determined. Additionally, total protein (TP), al-bumin, globulin, A/G ratio, total bilirubin, direct bilirubin, indirect bilirubin; and kidney functions [creatinine, urea, and uric acid]; and lipid profile as [total cholesterol, HDL-cholesterol and LDL-cholesterol, and triglycerides] were also, carried out. The obtained results showed accumulated weight gain which significantly increased in rats group administrated 40 and 80 mg/ Kg BW/d folic acid. No changes in relative liver weight among tested rat groups were recorded. No significant difference was observed in lipid profile, LDH and SOD between groups (F1 and F6). Data also indi-cated that F1 group recorded the best one which was low in MDA and high in CAT, followed by F6. Folic acid showed no effect on kidney func-tions. No histopathological changes were observed in liver of rat groups administered 40 or 80 mg folic acid / Kg BW/d, thus indicating that supple-mentation with high doses of FA had a protective effect from the hepatic oxidative stress in liver of tested rats

GIS AND STATISTICAL EVALUATION OF SOIL QUALITY OF SIDI YAHYA, GHARBPLAIN (MOROCCO)

The study of soil quality in irrigated areas is necessary to evaluate the sustainability of the agricultural production system. Indeed, the assessment of this quality is based on the physicochemical and biological characterization of soil parameters, as well as the knowledge of their spatial distribution and their evolution over time. This work aims to make a diagnosis of the current situation of soil quality of SidiYahya in the Gharb plain, Morocco. For this, sampling was carried out from 33 sites distributed over the studied plain during 2019. In this study, different soil properties including specifically texture, pH, electrical conductivity (EC), organic matter (OM), phosphorus (P2O5), and potassium (K2O) were measured while exchangeable sodium percentage (ESP) was calculated using the standard formula. Based on the observed soil properties a map was prepared by using a geographic information system (GIS), which was based specifically on the inverse distance weighted (IDW) spatial interpolation method. Data were processed using different statistical tools like descriptive statistics, correlation, and principal component analysis (PCA). Results of the study revealed that 70% of the soils have a heavy clayey texture with a predominance of vertisols (55%). Further, the study area soil is mainly alkaline (70%), poor in organic matter (61%) and phosphorus (52%), while very rich in potassium (70%), and non-saline (88%) contents. Soil pH was reported to be the least variable whereas sand, phosphorus, and salinity were the highest variable. IDW allowed mapping the soil properties by moving from punctual information to whole extent information. Furthermore, correlations were found between various soil properties by using PCA, 3 principal components (PCs) were able to extract 76% of the information from the 9 initial soil properties. Collected soil samples were grouped into 3 groups, based on their scores on the 3 PCs. Based on these two kinds of information, delineation of management zones can be established for a site-specific supply of agricultural inputs leading to better management of soil and water resources for securing their sustainable use

Revisiting the Prevalence of Autism Spectrum Disorder among Omani Children: A multicentre study

Objectives: This study aimed to provide an updated estimate of the prevalence of autism spectrum disorder (ASD) among Omani children. Methods: This retrospective descriptive study was conducted from December 2011 to December 2018. Data were retrieved from the three main autism diagnostic centres in Oman: Sultan Qaboos University Hospital, Royal Hospital and Al-Massarah Hospital. The ASD diagnosis was made by experienced clinicians based on the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The overall population prevalence estimates per 10,000 children aged 0–14 years old in Oman were calculated using the denominator of the mid-period population data. Results: A total of 1,705 ASD cases were identified with the majority of cases being male (78.1%). The overall prevalence rate of ASD was estimated at 20.35 per 10,000 children (95% confidence interval: 19.39–21.32) between 2012–2018. Boys were found to have a 3.4-fold higher prevalence of ASD than girls (31.23/10,000 versus 9.07/10,000). Regionally, the majority of cases were found in the capital, Muscat, where the highest prevalence was 36.51 cases per 10,000 children. Conclusion: The prevalence of ASD among Omani children is 15-fold higher than estimates from 2011. This increase can be attributed to improvements in diagnostic services, increased awareness of ASD, better screening programmes and changes in diagnostic criteria. In addition, this increase in prevalence suggests a need for a registry of developmental disabilities and more extensive diagnostic and rehabilitation services in Oman.Keywords: Autism Spectrum Disorder; Epidemiology; Prevalence; Oman

Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of Epidermal Growth Factor Receptor and Vascular Growth Factor Receptor phosphorylation

Patients suffering from bone metastases of Follicular Thyroid Carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of Epidermal Growth Factor Receptor (EGFR) associated with increased vascularity has been implicated in the pathogenesis of FTC and subsequent bone metastases. We hypothesized that inhibiting the phosphorylation of the EGFR and Vascular Endothelial Growth Factor Receptor (VEGFR) by AEE788, a dual tyrosine kinase inhibitor of EGFR and VEGFR, in combination with paclitaxel would inhibit experimental FTC bone lesions and preserve bone structure. We tested this hypothesis using the human WRO FTC cell line. In culture, AEE788 inhibited the EGF-mediated phosphorylation of EGFR, VEGFR2, mitogen-activated protein kinase and Akt in culture. AEE788, alone and in combination with paclitaxel, inhibited cell growth and induced apoptosis. When WRO cells were injected into the tibia of nude mice, tumor and endothelial cells within the lesions expressed phosphorylated EGFR, VEGFR, Akt and mitogen-activated protein kinase that were inhibited by the oral administration of AEE788. Therapy consisting of orally given AEE788 and i.p. injected paclitaxel induced a high level of apoptosis in tumor-associated endothelial cells and tumor cells with the inhibition of tumor growth in the bone and the preservation of bone structure. Collectively, these data show that blocking the phosphorylation of EGFR and VEGFR with AEE788 combined with paclitaxel can significantly inhibit experimental human FTC in the bone of nude mice

Effect of Tillage and Nitrogen Fertilization on Soil Properties and Yield of Five Durum Wheat Germoplasms in a Dry Area of Morocco

In Morocco, cereal production is below the expected potential. The adoption of best agricultural practices that reduce vulnerability to climate is a major requirement. No-tillage (NT) agriculture is a system that could improve cereal production by enhancing soil fertility. Some factors, in combination with no-tillage, can further improve cereal yields, especially the choice of variety the adequate fertilization. The objective of our study is to investigate the effect of no-tillage agriculture and nitrogen fertilization on soil fertility and the yield of five durum wheat varieties developed in Morocco in a long-term (18 years) NT trial at the INRA Merchouch experimental station, Morocco. The results show that tillage type had a significant effect on soil organic carbon and CEC (measured before the start of the experiment), as well as on ammonium and nitrates (measured at the end of the experiment), whereas nitrogen dose had a significant effect on total nitrogen and nitrates (measured at the end of the experiment). Regarding wheat yield, as measured at the end of the experiment during the 2020–2021 cropping season, the results show that, under NT, the varieties Nachit, Faraj, and Louiza had grain yields of 4.5, 4.3, and 3.4 t ha−1 and straw yields of 9.8, 7.8, and 6.8 t ha−1 ,respectively, whereas the I.C and M.G germoplasms had grain yields of 4.05 and 3.72 t ha−1 and straw yields of 8.25 and 8.39 t ha−1 , respectively. These values are low for a favorable area and correspond to a semi-arid area. In addition, no effects of nitrogen dose were observed due to water stress, which reduced nitrogen use efficiency. Nachit is the most adapted variety under NT, with the highest yield(5.1 t ha−1) under a low dose of nitrogen (20 kg N ha−1), followed by Faraj (4.7 t ha−1), still under NTbut with a higher nitrogen dose (40 kg N ha−1) and Nachit (4.5 t ha−1)with the minimum nitrogen dose but under both NT and CT. In conclusion, Nachit and Faraj wheat varieties performed thebest under no-tillage conditions with the minimal nitrogen dose. However, grain yield values were reduced, owing to water stress, which reduced nitrogen use efficiency