Effects of hydrostatic pressure on the mechanical behavior of body centered cubic refractory metals and alloys

Hydrostatic pressure on mechanical behavior of body centered cubic refractory metals and alloy

An ontological approach for recovering legacy business content

Legacy Information Systems (LIS) pose a challenge for many organizations. On one hand, LIS are viewed as aging systems needing replacement; on the other hand, years of accumulated business knowledge have made these systems mission-critical. Current approaches however are often criticized for being overtly dependent on technology and ignoring the business knowledge which resides within LIS. In this light, this paper proposes a means of capturing the business knowledge in a technology agnostic manner and transforming it in a way that reaps the benefits of clear semantic expression - this transformation is achieved via the careful use of ontology. The approach called Content Sophistication (CS) aims to provide a model of the business that more closely adheres to the semantics and relationships of objects existing in the real world. The approach is illustrated via an example taken from a case study concerning the renovation of a large financial system and the outcome of the approach results in technology agnostic models that show improvements along several dimensions

Alexithymia in anorexia and bulimia: Ubiquitous and primary trait?

Background: Alexithymia is associated to Eating Disorders (ED) and relevant for their prognosis but it is uncertain if it is ubiquitous, primary, and necessary for ED outburst. Methods: 124 ED outpatients and 80 healthy controls were compared with the Toronto Alexithymia Scale, personality, and psychopathology measures. Alexithymia and the other features are compared between anorexia nervosa (AN), bulimia nervosa (BN) and control groups. Alexithymia-based clusters were explored and compared with controls. Alexithymia traits are correlated with the other features. Results: Difficulty in identifying feelings was ubiquitous in ED subjects. A Non-Alexithymic Cluster (NAC) and an Alexithymic Cluster (ALC) were found with no difference in AN/BN distribution. ALC displays disordered personality and high psychopathology. Self-directiveness and interoceptive awareness were independently related to alexithymia and to depressive feelings. These two features along with depressive features completely accounted for alexithymia variance. Conclusion: Even though the difficulty in identifying feelings is ubiquitous in ED subjects, Alexithymia may not represent a primary trait but a complex dysfunction consequent to co-occurring character immaturity, altered interoceptive awareness, and depressive traits

Generation of thermo-sensitive allele of the TPR like protein Nup211by PCR mutagenesis

Motivation: TPR proteins are conserved large coiled-coil proteins that localize at the nucleoplasmic side of the nuclear pore complex and participate in multiple aspects of DNA metabolism. The protein Nup211, fission yeast homolog of Mlp1/Mlp2/Tpr, participate in the mRNA export and is essential for vegetative growth. The aim of this work is to create a collection of thermo-sensitive alleles of nup211.Methods: To create the collection, we have generated a new strain with the nup211 gen tagged with GFP at the amino terminal extreme and confirmed by fluorescent microscopy that the protein Nup211 localized in the nuclear envelop. Then, we have carried out a Taq PCR-based Random Mutagenesis with reduced concentration of dATP. The PCR products were transformed into a wild type strain to generate conditional mutants. The transformants obtained whose growth was impaired at 36ºC were preselected as thermo-sensitive mutants. To confirm the growth deficiency of these clones, a drop assay was performed and the best candidates were selected. These thermo-sensitive mutants were cultivated at 25ºC as well as 36ºC and both cultures were subjected to various experiments in order to study any changes in the localization of Nup211.Results: Up to now, we have demonstrated by fluorescent microscopy that the thermo-sensitive mutants show a modified nuclear distribution of Nup211 and different cellular phenotype, suggesting that the differents clones might represent differents nup211 thermo-sensitive alleles. These alleles are going to be subjected to various experiments to clarify the role of the protein in the mRNA export

Sol : attention fragile ! Les enjeux sociétaux liés à la consommation des sols

Cet article restitue une partie des résultats du projet OSDDT « Occupation des Sols et Développement Durable du Territoire » financé dans le cadre du programme MED. Le projet se place dans la droite ligne de la proposition de Directive du Parlement Européen et du Conseil de 2006, qui souligne que : « le sol est une ressource d’intérêt général pour la communauté, bien qu’il relève pour l’essentiel de la propriété privée, et sa non protection nuit au développement durable et à long terme, à la compétitivité de l’Europe. » Il a permis la mise au point d’un modèle de suivi et d’évaluation de l’utilisation des sols, construit sur des critères d’approches communs aux partenaires européens de l’arc méditerranéen. Ce modèle a l’ambition d’augmenter la capacité des acteurs publics qui gèrent les différents instruments de planification du territoire et ont contribué au cours des 20 dernières années à une consommation très dispendieuse, de repenser leurs modes de gestion dans une optique de développement durable et de sauvegarde des sols naturels

Soil: fragile ! Be careful ! The challenges to society from its over-consumption of land

Cet article restitue une partie des résultats du projet OSDDT « Occupation des Sols et Développement Durable du Territoire » financé dans le cadre du programme MED. Le projet se place dans la droite ligne de la proposition de Directive du Parlement Européen et du Conseil de 2006, qui souligne que : « le sol est une ressource d’intérêt général pour la communauté, bien qu’il relève pour l’essentiel de la propriété privée, et sa non protection nuit au développement durable et à long terme, à la compétitivité de l’Europe. » Il a permis la mise au point d’un modèle de suivi et d’évaluation de l’utilisation des sols, construit sur des critères d’approches communs aux partenaires européens de l’arc méditerranéen. Ce modèle a l’ambition d’augmenter la capacité des acteurs publics qui gèrent les différents instruments de planification du territoire et ont contribué au cours des 20 dernières années à une consommation très dispendieuse, de repenser leurs modes de gestion dans une optique de développement durable et de sauvegarde des sols naturels