Les tabous en didactique : aspects linguistiques, littéraires et culturels.: Session 1 - Matinée

Cette vidéo présente la première session de la journée d'étude "Les tabous en didactique : aspects linguistiques, littéraires et culturels", organisée par Delphine DUMAN (PLIDAM/CERMOM, Inalco)

Les tabous en didactique : aspects linguistiques, littéraires et culturels.: Session 2 - Après-midi

Cette vidéo présente la deuxième session de la journée d'étude "Les tabous en didactique : aspects linguistiques, littéraires et culturels", organisée par Delphine DUMAN (PLIDAM/CERMOM, Inalco)

Plurilinguisme et tensions identitaires : discours, représentations et médiations.: Journée d'étude, Après-midi

Cette vidéo présente la deuxième session de la journée d'étude "Plurilinguisme et tensions identitaires : discours, représentations et médiations", organisée par Liliane HODIEB (PLIDAM, Inalco).L’enseignement-apprentissage des langues doit prendre en compte la diversité des situations plurilingues dans les régions les plus diverses du monde, avec en présence, des langues transnationales, nationales, régionales et locales. En tant que vecteur essentiel de l’identité et tributaire de dimensions idéologiques et politiques, le statut d’une langue est l’expression de rapports de force entre groupes sociaux.Traversée de questionnements culturels, la didactique des langues articule ces divers éléments constitutifs de l’identité.Cette journée d’étude est l’occasion d’approfondir la réflexion sur les phénomènes de plurilinguisme et sur des questions de politique linguistique, afin de rendre compte de l’hétérogénéité des conflits identitaires et sociaux (milieux professionnel, religieux, etc. ; Etrillard, 2014, Dompmartin-Normand et Thamin 2013) engendrés par les mutations que connaît le monde actuel

Les tabous en didactique : aspects linguistiques, littéraires et culturels.: Session 2 - Après-midi

Cette vidéo présente la deuxième session de la journée d'étude "Les tabous en didactique : aspects linguistiques, littéraires et culturels", organisée par Delphine DUMAN (PLIDAM/CERMOM, Inalco)

Effects of maternal modafinil treatment on fetal development and neonatal growth parameters - a multicenter case series of the European Network of Teratology Information Services (ENTIS)

Objective: In recent years, safety concerns about modafinil exposure during pregnancy have emerged. In particular, increased risks for major congenital anomalies (MCA) and impaired fetal growth were reported, although study results were conflicting. Our investigation aims to examine previously reported safety signals. Method: Multicenter case series based on data from 18 Teratology Information Services from 12 countries. Modafinil exposed pregnancies with an estimated date of birth before August 2019 were included in this study. For prospectively ascertained pregnancies, cumulative incidences of pregnancy outcomes, rate of nonchromosomal MCA in first trimester exposed pregnancies and percentiles of neonatal/infant weight and head circumference (HC) were calculated. Potential dose-dependent effects on fetal growth were explored by linear regression models. Retrospectively ascertained cases were screened for pattern of MCA and other adverse events. Results: One hundred and seventy-five prospectively ascertained cases were included, of which 173 were exposed at least during the first trimester. Cumulative incidences for live birth, spontaneous abortion and elective termination of pregnancy were 76.9% (95% CI, 68.0%-84.8%), 9.3% (95% CI, 5.0%-16.9%), and 13.9% (95% CI, 8.1%-23.1%), respectively. Nonchromosomal MCA was present in 3/150 live births, corresponding to an MCA rate of 2.0% (95%CI, 0.6%-6.1%), none were reported in pregnancy losses. Compared to reference standards, birth weight (BW) tended to be lower and neonatal HC to be smaller in exposed newborns (data available for 144 and 73 of 153 live births, respectively). In nonadjusted linear regression models, each 100 mg increase of average dosage per pregnancy day was associated with a decrease in standard deviation score (SDS) of -0.28 SDS (95% CI, -0.45 to -0.10) for BW and of -0.28 SDS (95% CI, -0.56 to 0.01) for HC. Screening of 22 retrospectively reported cases did not reveal any specific pattern of MCA or other adverse outcomes. Conclusion: The results do not indicate an increased risk of MCA after in utero exposure to modafinil, but a tendency toward lower BW and reduced neonatal HC. However, these findings should be regarded as preliminary. Until further studies allow for a definite conclusion, modafinil should not be used during pregnancy.The Berlin Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy is financially supported by the German Federal Institute for Drugs and Medical Devices (BfArM); included German study cases were obtained from the Embryotox cohort. The UK Teratology Information Service is funded by the UK Health Security Agency. The Dutch Teratology Information Service is funded by the Ministerie van Volksgezondheid, Welzijnen Sport Research Unit on Congenital Anomalies-UIAC & Spanish Teratology Information Services SITTE and SITE are financially supported by Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, of Spain.S