Serotonin reuptake inhibitors and cardiovascular disease

Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels. Platelet aggregation is a major component of acute coronary syndromes, including sudden death, and also of limb ischaemia. Platelet-released serotonin causes constriction of diseased blood vessels. The recent literature has revealed a number of reports of association between the treatment of depression with SSRIs and reduced events caused by intra-arterial thrombosis. The effects of serotonin and serotonin depletion upon intracoronary thrombosis, diseased blood vessels, blood platelets and bleeding are discussed with recommendations for future research into the potential cardiovascular benefits of SSRIs and serotonin 5HT2A antagonists

Origin of asymmetries in X-ray emission lines from the blast wave of the 2014 outburst of nova V745 Sco

The symbiotic nova V745 Sco was observed in outburst on 2014 February 6. Its observations by the Chandra X-ray Observatory at days 16 and 17 have revealed a spectrum characterized by asymmetric and blue-shifted emission lines. Here we investigate the origin of these asymmetries through three-dimensional hydrodynamic simulations describing the outburst during the first 20 days of evolution. The model takes into account thermal conduction and radiative cooling and assumes a blast wave propagates through an equatorial density enhancement. From the simulations, we synthesize the X-ray emission and derive the spectra as they would be observed with Chandra. We find that both the blast wave and the ejecta distribution are efficiently collimated in polar directions due to the presence of the equatorial density enhancement. The majority of the X-ray emission originates from the interaction of the blast with the equatorial density enhancement and is concentrated on the equatorial plane as a ring-like structure. Our "best-fit" model requires a mass of ejecta in the outburst $M_{ej} \approx 3\times 10^{-7}\,M_{\odot}$ and an explosion energy $E_b \approx 3 \times 10^{43}$ erg and reproduces the distribution of emission measure vs temperature and the evolution of shock velocity and temperature inferred from the observations. The model predicts asymmetric and blue-shifted line profiles similar to those observed and explains their origin as due to substantial X-ray absorption of red-shifted emission by ejecta material. The comparison of predicted and observed Ne and O spectral line ratios reveals no signs of strong Ne enhancement and suggests the progenitor is a CO white dwarf.Comment: 16 pages, 17 Figures; accepted for publication on MNRA

Parallel electric fields are inefficient drivers of energetic electrons in magnetic reconnection

We present two-dimensional kinetic simulations, with a broad range of initial guide fields, that isolate the role of parallel electric fields ($E_\parallel$) in energetic electron production during collisionless magnetic reconnection. In the strong guide field regime, $E_\parallel$ drives essentially all of the electron energy gain, yet fails to generate an energetic component. We suggest that this is due to the weak energy scaling of particle acceleration from $E_\parallel$ compared to that of a Fermi-type mechanism responsible for energetic electron production in the weak guide-field regime. This result has important implications for energetic electron production in astrophysical systems and reconnection-driven dissipation in turbulence

The role of three-dimensional transport in driving enhanced electron acceleration during magnetic reconnection

Magnetic reconnection is an important driver of energetic particles in many astrophysical phenomena. Using kinetic particle-in-cell (PIC) simulations, we explore the impact of three-dimensional reconnection dynamics on the efficiency of particle acceleration. In two-dimensional systems, Alfv\'enic outflows expel energetic electrons into flux ropes where they become trapped and disconnected from acceleration regions. However, in three-dimensional systems these flux ropes develop axial structure that enables particles to leak out and return to acceleration regions. This requires a finite guide field so that particles may move quickly along the flux rope axis. We show that greatest energetic electron production occurs when the guide field is of the same order as the reconnecting component: large enough to facilitate strong transport, but not so large as to throttle the dominant Fermi mechanism responsible for efficient electron acceleration. This suggests a natural explanation for the envelope of electron acceleration during the impulsive phase of eruptive flares

Advanced infrared astronomy

This task supports the application of infrared heterodyne and Fourier transform spectroscopy to ultra-high resolution studies of molecular constituents of planetary astomspheres and cometary comae. High spectral and spatial resolutions are especially useful for detection and study of localized, non-thermal phenomena in low temperature and low density regions, for detection of trace constituents and for measurement of winds and dynamical phenomena such as thermal tides. Measurement and analysis of individual spectial lines permits retrieval of atmospheric molecular abundances and temperatures and thus, information on local photochemical processes. Determination of absolute line positions to better than 10 to the minus eighth power permits direct measurements of gas velocity to a few meters/sec. Observations are made from ground based heterodyne spectrometers at the Kitt Peak McMath solar telescope and from the NASA infrared Telescope Facility on Mauna Kea, Hawaii. Wind velocities at 110km altitude on Venus were extracted approximately 1 m/sec from measurements of non-thermal emission cores of 10.3 micron CO2 lines. Results indicate a subsolar to antisolar circulationwith a small zonal retrograde component

X-ray Development of the Classical Nova V2672 Ophiuchi with Suzaku

We report the Suzaku detection of a rapid flare-like X-ray flux amplification early in the development of the classical nova V2672 Ophiuchi. Two target-of-opportunity ~25 ks X-ray observations were made 12 and 22 days after the outburst. The flux amplification was found in the latter half of day 12. Time-sliced spectra are characterized by a growing supersoft excess with edge-like structures and a relatively stable optically-thin thermal component with Ka emission lines from highly ionized Si. The observed spectral evolution is consistent with a model that has a time development of circumstellar absorption, for which we obtain the decline rate of ~10-40 % in a time scale of 0.2 d on day 12. Such a rapid drop of absorption and short-term flux variability on day 12 suggest inhomogeneous ejecta with dense blobs/holes in the line of sight. Then on day 22 the fluxes of both supersoft and thin-thermal plasma components become significantly fainter. Based on the serendipitous results we discuss the nature of this source in the context of both short- and long-term X-ray behavior.Comment: To appear in PASJ; 9 pages, 5 figures, 2 table