21 research outputs found
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ N(ΡΠΎΡΡΠΎΠ½ΠΎΠΌΠ΅ΡΠΈΠ»)-Π³Π»ΠΈΡΠΈΠ½Π° Π½Π° ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠ°Π·Ρ Π2
The effect of N(phosphonomethyl)-glycine (glyphosate), the active ingredient of the Β«SquallΒ» herbicide in a wide range of concentrations (1-1000 |ig/ml) on phospholipolysis catalyzed by pancreatic phospholipase A2 (PLA2, 3.1.1.4), under the conditions similar to digestion in the duodenum (pH 8.0, temperature S, micellar form PC), has been studied. It has been shown that a rapid method based on the use of in vitro phospholipolytic reaction as a simple model of the process of destruction of food and phospholipids of cell membranes, is promising for preliminary evaluation of the pesticide safety to humans and animals.ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ N(ΡΠΎΡΡΠΎΠ½ΠΎΠΌΠ΅ΡΠΈΠ»)-Π³Π»ΠΈΡΠΈΠ½Π° (Π³Π»ΠΈΡΠΎΡΠ°ΡΠ°) - Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° Π³Π΅ΡΠ±ΠΈΡΠΈΠ΄Π° Β«Π¨ΠΊΠ²Π°Π»Β» Π² ΡΠΈΡΠΎΠΊΠΎΠΌ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ (1-1000 ΠΌΠΊΠ³/ΠΌΠ») Π½Π° ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ, ΠΊΠ°ΡΠ°Π»ΠΈΠ·ΠΈΡΡΠ΅ΠΌΡΡ ΠΏΠ°Π½ΠΊΡΠ΅Π°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠ°Π·ΠΎΠΉ Π2 (Π€ΠΠ2, ΠΠ€ 3.1.1.4), Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
, Π±Π»ΠΈΠ·ΠΊΠΈΡ
ΠΊ ΠΏΠΈΡΠ΅Π²Π°ΡΠ΅Π½ΠΈΡ Π² Π΄Π²Π΅Π½Π°Π΄ΡΠ°ΡΠΈΠΏΠ΅ΡΡΡΠ½ΠΎΠΉ ΠΊΠΈΡΠΊΠ΅ (ΡΠ 8,0, ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ° 37 Β°Π‘, ΠΌΠΈΡΠ΅Π»Π»ΡΡΠ½Π°Ρ ΡΠΎΡΠΌΠ° Π€Π₯). ΠΠ²ΡΠΌΡ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠΌΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΎΠ»ΠΈΠ·Π° - Π»ΠΈΠ·ΠΎΡΠΎΡΡΠ°ΡΠΈΠ»ΠΈΠ»Ρ
ΠΎΠ»ΠΈΠ½Π° (Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π’Π‘Π₯) ΠΈ ΠΆΠΈΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ (Ρ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΏΠΎΠ΄ Π΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΡΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ MetHb), ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠ°Π·Π½ΠΎΠ½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π³Π»ΠΈΡΠΎΡΠ°ΡΠ° Π½Π° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π€ΠΠ2: Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΡ
Π΄Π»Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π΄ΠΎΠ· (Π΄ΠΎ 100 ΠΌΠΊΠ³/ΠΌΠ») - Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π² 1,4 ΡΠ°Π·Π°, Π° ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π·Π°ΠΏΡΠ΅Π΄Π΅Π»ΡΠ½ΡΡ
Π΄ΠΎΠ· (Π΄ΠΎ 1000 ΠΌΠΊΠ³/ΠΌΠ») - ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠ²Π°Π½ΠΈΠ΅ Π΄ΠΎ 20% ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. ΠΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π³Π»ΠΈΡΠΎΡΠ°ΡΠ° Π² ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ 0,5 ΠΌΠ ΠΏΡΠΈ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΌ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·Π΅ Π€Π₯ Π² ΠΌΠΈΡΠ΅Π»Π»ΡΡΠ½ΠΎΠΉ ΡΠ°Π·Π΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π²Π΅Π»ΠΈΡΠΈΠ½ΠΎΠΉ Πi ΡΠ°Π²Π½ΠΎΠΉ 24 ΠΌΠ, Π° ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½ΠΎΡΠΈΡ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡ-ΠΌΠ΅ΡΠΎΠ΄ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ in vitro ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΡΠΎΡΡΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠ°Π·ΡΡΡΠ΅Π½ΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈ-Π΄ΠΎΠ² ΠΏΠΈΡΠΈ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅Π½ Π² ΡΠ΅Π»ΡΡ
ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΠ΅ΡΡΠΈΡΠΈΠ΄ΠΎΠ² Π΄Π»Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Modelling Foreign Real Estate Investment: The Spanish Case
Foreign real estate investment, Housing investment bubble, Foreign direct investment,
From piecewise to full physiologic pharmacokinetic modeling: Applied to thiopental disposition in the rat
Tumor-targeted gene delivery of tumor necrosis factor-Ξ± induces tumor necrosis and tumor regression without systemic toxicity
PEGylated DNA/transferrinβPEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
Synthesis and biodistribution of bowman-birk soybean protease inhibitor conjugate with amphiphilic polyester
Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines
A Distributed Parameter Physiologically-Based Pharmacokinetic Model for Dermal and Inhalation Exposure to Volatile Organic Compounds
Pharmacokinetics of paclitaxel-containing liposomes in rats
In animal models, liposomal formulations of paclitaxel possess lower toxicity and equal antitumor efficacy compared with the clinical formulation, Taxol. The goal of this study was to determine the formulation dependence of paclitaxel pharmacokinetics in rats, in order to test the hypothesis that altered biodistribution of paclitaxel modifies the exposure of critical normal tissues. Paclitaxel was administered intravenously in either multilamellar (MLV) liposomes composed of phosphatidylglycerol/phosphatidylcholine (L-pac) or in the Cremophor EL/ethanol vehicle used for the Taxol formulation (Cre-pac). The dose was 40 mg/kg, and the infusion time was 8 to 9 minutes. Animals were killed at various times, and pharmacokinetic parameters were determined from the blood and tissue distribution of paclitaxel. The area under the concentration vs time curve (AUC) for blood was similar for the 2 formulations (L-pac: 38.1Β±3.32 ΞΌg-h/mL; Cre-pac: 34.5Β±0.994 ΞΌg-h/mL), however, the AUC for various tissues was formulation-dependent. For bone marrow, skin, kidney, brain, adipose, and muscle tissue, the AUC was statistically higher for Cre-pac. For spleen, a tissue of the reticuloendothelial system that is important in the clearance of liposomes, the AUC was statistically higher for L-pac. Apparent tissue partition coefficients (Kp) also were calculated. For bone marrow, a tissue in which paclitaxel exerts significant toxicity, Kp was 5-fold greater for paclitaxel in Cre-pac. The data are consistent with paclitaxel release from circulating liposomes, but with efflux delayed sufficiently to retain drug to a greater extent in the central (blood) compartment and reduce penetration into peripheral tissues. These effects may contribute to the reduced toxicity of liposomal formulations of paclitaxel