Knowledge and Implementation of the Promotion Policies of Elementary Teachers and Administrators in the Division of Misamis Oriental

The study attempted to determine the knowledge and awareness level of teachers and administrators on promotion policies and extent of implementation of the Implementing Rules and Regulation of Republic Act 9155. There were 424 teachers and administrators who were the respondents of the study, randomly selected from the 24 Districts in the Division of Misamis Oriental. Findings revealed that majority of the teachers and administrators in the Division of Misamis Oriental are aware of the promotion policies. As to comparison of their responses, majority of them like the provision of DepEd Orders No. 42 and 39 s. 2007. Majority of the respondents are also aware on the extent of implementation of Republic Act 9155, its Implementing Rules and Regulations specifically on promotion. There is a significant relationship between the knowledge and awareness level of administrators and teachers on promotion policies and related factors namely: number of trainings and seminars attended educational qualification and the position held by the respondents. There is no significant relationship between the knowledge and awareness level of administrators and teachers on promotion policies with some related variables namely: age, gender, length of service, monthly salary, and performance rating

Implementation of Strengthened Technical Vocational Education Program - Competency Based Curriculum, Northern Mindanao, Philippines

This study attempted to assess the implementation of the Strengthened Technical and Vocational Education Program - Competency Based Curriculum (STVEP-CBC) in Region x. The study involved nine (9) DepED Technical Vocational High Schools in Region X - Northern Mindanao. The respondents included twenty one (21) administrators and ninety one (91) teachers. Descriptive statistics were used to describe and to analyze the data. The study also utilized T - test for paired values to evaluate the difference between administrators and teachers assessments in the status of implementation of STVEP - CBC. The school administrators and teachers assessed the status of the implementation of STVEP-CBC along the aspects of its program. Findings show that both administrators and teacher respondents were assessed very satisfactory on items of Competency Assessment and Certification, Instructional and Teacher Support Material, Curriculum Instruction, Program and Project Management and Monitoring and Evaluation. On one hand, both respondents register as only satisfactory on the aspect of facilities and services. This can be due to the fact that a budgetary allocation in this area is insufficient. On the other hand, assessments of administrators and teachers vary on the following: excellent by the administrators while very satisfactory by the teachers respectively the items on Human Resource Development, Property Supply Management, Fiscal Management and Physical Plant Facility. Such high assessments of the two groups are attributed to their satisfaction level with the implementation of the different programs

BRYOSTATIN-1 LIMITS NEUTROPHIL TRANSENDOTHELIAL MIGRATION FOLLOWING ISCHEMIA-REPERFUSION INJURY: IMPACT FOR THERAPY

Poster presentation to the 25th Annual Meeting of the German Transplantation Society, Essen, Germany, 5–8 October 2016.Introduction and Background: Ischemia-reperfusion injury (IRI) is an inherent component of solid organ transplantation and axiomatically linked to graft damage. In the kidney, vascular endothelial cells (EC) are highly vulnerable to IRI. These cells are the first site of graft injury, while neutrophils are the first line of host defense after reperfusion. The degree of renal EC damage predicts the severity of neutrophil transendothelial migration (TEM), with neutrophils in turn orchestrating the influx of subsequent leukocytes waves into the graft. Therefore, EC integrity and neutrophil TEM represent promising targets to attenuate IRI. One drug known to stabilize EC integrity and to limit neutrophil TEM is Bryostatin-1, an activator of the EC second messenger protein kinase C delta. Therefore, we examined the role of Bryostatin-1 on neutrophil TEM in an in vitro IRI model. Methods: We used an in vitro IRI model with human umbilical vein ECs (HUVECs) and human neutrophils (approved by the ethic committee (STUDY00000261) to study the role of Bryostatin-1 in IRI-induced neutrophil TEM. HUVECs were exposed to either normoxic (21% O2) or hypoxic (1.5% O2) conditions for 20 hours (h) with and without Bryostatin-1 (1-100 nM) followed by 2 h exposure to Calcein-AM dye labeled neutrophils. TEM to saline or the chemoattractant leukotriene B4 (LTB4) was determined by measuring fluorescence intensity and myeloperoxidase (MPO) production. Results and Conclusions: Bryostatin-1 dose-dependently inhibited human neutrophil TEM under normoxic and hypoxic conditions. Bryostatin-1 (100 nM) blocked 75% (P < 0.05) of TEM toward LTB4 in normoxic conditions; this was intensified when HUVECs were placed in hypoxic conditions (83%, P < 0.001). These data were further supported by a mirrored effect when MPO production (a marker of neutrophil activation) was measured. In summary, these promising in vitro results demonstrate that our model recapitulates IRI-induced EC damage, and most importantly that Bryostatin-1 alters neutrophil TEM in an in vitro IRI model

Protocol of the baseline assessment for the Environments for Healthy Living (EHL) Wales cohort study

Background Health is a result of influences operating at multiple levels. For example, inadequate housing, poor educational attainment, and reduced access to health care are clustered together, and are all associated with reduced health. Policies which try to change individual people's behaviour have limited effect when people have little control over their environment. However, structural environmental change and an understanding of the way that influences interact with each other, has the potential to facilitate healthy choices irrespective of personal resources. The aim of Environments for Healthy Living (EHL) is to investigate the impact of gestational and postnatal environments on health, and to examine where structural change can be brought about to optimise health outcomes. The baseline assessment will focus on birth outcomes and maternal and infant health. Methods/Design EHL is a longitudinal birth cohort study. We aim to recruit 1000 pregnant women in the period April 2010 to March 2013. We will examine the impact of the gestational environment (maternal health) and the postnatal environment (housing and neighbourhood conditions) on subsequent health outcomes for the infants born to these women. Data collection will commence during the participants' pregnancy, from approximately 20 weeks gestation. Participants will complete a questionnaire, undergo anthropometric measurements, wear an accelerometer, compile a food diary, and have environmental measures taken within their home. They will also be asked to consent to having a sample of umbilical cord blood taken following delivery of their baby. These data will be complemented by routinely collected electronic data such as health records from GP surgeries, hospital admissions, and child health and development records. Thereafter, participants will be visited annually for follow-up of subsequent exposures and child health outcomes. Discussion The baseline assessment of EHL will provide information concerning the impact of gestational and postnatal environments on birth outcomes and maternal and infant health. The findings can be used to inform the development of complex interventions targeted at structural, environmental factors, intended to reduce ill-health. Long-term follow-up of the cohort will focus on relationships between environmental exposures and the later development of adverse health outcomes, including obesity and diabetes