Analysis Expression of ZIP1 and Caspase-3 Protein in Adenocarsinoma of the Prostate

Background: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells. Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyse the correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason Score. This was a cross-sectional, retrospective analytical study on 31 Formalin-fixed, paraffin-embedded tissue that meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3. Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from the cases' reports. The correlation of their expression with respect to Gleason score was analysed with Pearson's correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were 35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression (r=0.379; p=0.018). However, their correlation was stronger in intermediate-grade group (r=0.73; p=0.01) and the correlation was much weaker in high-grade group (r=0.04; p=0.48). Conclusions: There was a positive correlation between ZIP1 and Caspase-3 expression in prostate adenocarcinoma.&nbsp

Bank response to capital requirements: Theory and Indian evidence

The paper discusses the theory of how banks' respond to risk-based capital standards and conducts an empirical estimation to ascertain the response of banks to capital requirements in the Indian contextcapital; banking; India

Regulating Market Risks in Banks: A Comparison of Alternate Regulatory Regimes

Regulators have traditionally used simple models to measure the capital adequacy of banks. The growing internationalisation and universalisation of banking operations have meant that the same is no longer possible, as banks face increasing, and increasingly opaque, market risk. The significance of market risk has also been acknowledged in the New Capital Accord enunciated by the Basel Committee in 1999. The focus of the paper is on market risk, that is, any market related factor that affects the value of a position in the financial instrument or a portfolio of instruments. As it stands at present, the three commonly used approaches to regulating market risks in banks include the building block approach, internal model approach and precommitment approach. The paper evaluates the pros and cons of the various approaches and concludes with a discussion of the applicability of these models in the Indian context.VaR; banking; India; market risk

Penerapan Algoritma Apriori terhadap Data Penjualan di Toko Gudang BM

Kemudahan untuk menjual suatu produk di pasaran menggunakan media internet membuat banyaknya pedagang – pedagang baru bermunculan. Keterbatasan modal menjadi kendala sebagian besar pedagang baru tersebut. Penerapan algoritma apriori untuk mencari produk yang laku di pasaran dapat mengatasi masalah pedagang baru tersebut. Algoritma apriori merupakan salah satu cabang dari data mining, yang berfungsi untuk mencari informasi – informasi dari sebuah kumpulan data. Dalam penelitian ini, hasil algoritma apriori dapat digunakan untuk menjadi bahan pertimbangan dalam membuat strategi pemasaran, pengoptimalan penjualan, serta sebagai bahan pertimbangan untuk melakukan penyetokan ulang