A Distance-Based Test of Association Between Paired Heterogeneous Genomic Data

Due to rapid technological advances, a wide range of different measurements can be obtained from a given biological sample including single nucleotide polymorphisms, copy number variation, gene expression levels, DNA methylation and proteomic profiles. Each of these distinct measurements provides the means to characterize a certain aspect of biological diversity, and a fundamental problem of broad interest concerns the discovery of shared patterns of variation across different data types. Such data types are heterogeneous in the sense that they represent measurements taken at very different scales or described by very different data structures. We propose a distance-based statistical test, the generalized RV (GRV) test, to assess whether there is a common and non-random pattern of variability between paired biological measurements obtained from the same random sample. The measurements enter the test through distance measures which can be chosen to capture particular aspects of the data. An approximate null distribution is proposed to compute p-values in closed-form and without the need to perform costly Monte Carlo permutation procedures. Compared to the classical Mantel test for association between distance matrices, the GRV test has been found to be more powerful in a number of simulation settings. We also report on an application of the GRV test to detect biological pathways in which genetic variability is associated to variation in gene expression levels in ovarian cancer samples, and present results obtained from two independent cohorts

Sustainable IT at Intel: A Teaching Case

Sustainable IT involves the responsible management of resources (both IT and non-IT) encompassing environmental, economic, and social dimensions. Sustainable IT has the potential to be a significant contributor to an organizations sustainability strategy. In this teaching case, we examine what Intel IT has done to transform its operations with Sustainable IT, resulting in the avoidance of significant CO2 emissions and cost savings. This teaching case challenges the reader to analyze the Sustainable IT capability at Intel. The case includes insights into strategic and operational challenges of planning and managing Sustainable IT

DESIGNING NEXT GENERATION SMART CITY INITIATIVES - HARNESSING FINDINGS AND LESSONS FROM A STUDY OF TEN SMART CITY PROGRAMS

The proliferation of Smart Cities initiatives around the world is part of the strategic response by governments to the challenges and opportunities of increasing urbanization and the rise of cities as the nexus of societal development. As a framework for urban transformation, Smart City initiatives aim to harness Information and Communication Technologies and Knowledge Infrastructures for economic regeneration, social cohesion, better city administration and infrastructure management. However, experiences from earlier Smart City initiatives have revealed several technical, management and governance challenges arising from the inherent nature of a Smart City as a complex Socio-technical System of Systems . While these early lessons are informing modest objectives for planned Smart Cities programs, no rigorous developed framework based on careful analysis of existing initiatives is available to guide policymakers, practitioners, and other Smart City stakeholders. In response to this need, this paper presents a Smart City Initiative Design (SCID) Framework grounded in the findings from the analysis of ten major Smart Cities programs from Netherlands, Sweden, Malta, United Arab Emirates, Portugal, Singapore, Brazil, South Korea, China and Japan. The findings provide a design space for the objectives, implementation options, strategies, and the enabling institutional and governance mechanisms for Smart City initiatives

Cloud Computing Adoption: An SME Case Study

Cloud Computing is a paradigm shift in IT services delivery. This shift promises large gains in agility, efficiency and flexibility at a time when demands on data centres are growing exponentially. Despite the importance of Cloud Technology there is a dearth of research of Cloud Technology adoption in Small and Medium Enterprises. This paper seeks to address this challenge by conducting Case Study research based on Design Science and Engaged Scholarship on an SME who is in the process of developing a capability in this area. A framework called the IT-CMF was used. The framework enabled a measurement capability that will be an invaluable tool for the company as it ensures that risks are mitigated and the opportunities created by cloud computing are maximized in a planned and controlled way

Aerothermal test results from the first flight of the Pegasus air-launched space booster

A survey of temperature measurements at speeds through Mach 8.0 on the first flight of the Pegasus air-launched booster system is discussed. In addition, heating rates were derived from the temperature data obtained on the fuselage in the vicinity of the wing shock interaction. Sensors were distributed on the wing surfaces, leading edge, and on the wing-body fairing or fillet. Side-by-side evaluations were obtained for a variety of sensor installations. Details of the trajectory reconstruction through first-stage separation are provided. Given here are indepth descriptions of the sensor installations, temperature measurements, and derived heating rates along with interpretations of the results

Climate-Resilient UAVs: Enhancing Energy-Efficient B5G Communication in Harsh Environments

This paper explores the crucial role of Unmanned Aerial Vehicles (UAVs) in advancing Beyond Fifth Generation (B5G) communication networks, especially in adverse weather conditions like rain, fog, and snow. The study investigates the synergy between climate-resilient UAVs and energy-efficient B5G communication. Key findings include the impact of weather elements on UAV coverage and communication dynamics. The research demonstrates significant enhancements in energy efficiency, reduced interference, increased data transmission rates, and optimal channel gain under various weather conditions. Overall, this paper emphasizes the potential of climate-resilient UAVs to improve energy-efficient B5G communication and highlights technology's role in mitigating climate change's impact on communication systems, promoting sustainability and resilience