Design of a single-chip pH sensor using a conventional 0.6-μm CMOS process

A pH sensor fabricated on a single chip by an unmodified, commercial 0.6-/spl μm CMOS process is presented. The sensor comprises a circuit for making differential measurements between an ion-sensitive field-effect transistor (ISFET) and a reference FET (REFET). The ISFET has a floating-gate structure and uses the silicon nitride passivation layer as a pH-sensitive insulator. As fabricated, it has a large threshold voltage that is postulated to be caused by a trapped charge on the floating gate. Ultraviolet radiation and bulk-substrate biasing is used to permanently modify the threshold voltage so that the ISFET can be used in a battery-operated circuit. A novel post-processing method using a single layer of photoresist is used to define the sensing areas and to provide robust encapsulation for the chip. The complete circuit, operating from a single 3-V supply, provides an output voltage proportional to pH and can be powered down when not required

A direct-sequence spread-spectrum communication system for integrated sensor microsystems

Some of the most important challenges in health-care technologies have been identified to be development of noninvasive systems and miniaturization. In developing the core technologies, progress is required in pushing the limits of miniaturization, minimizing the costs and power consumption of microsystems components, developing mobile/wireless communication infrastructures and computing technologies that are reliable. The implementation of such miniaturized systems has become feasible by the advent of system-on-chip technology, which enables us to integrate most of the components of a system on to a single chip. One of the most important tasks in such a system is to convey information reliably on a multiple-access-based environment. When considering the design of telecommunication system for such a network, the receiver is the key performance critical block. The paper describes the application environment, the choice of the communication protocol, the implementation of the transmitter and receiver circuitry, and research work carried out on studying the impact of input data characteristics and internal data path complexity on area and power performance of the receiver. We provide results using a test data recorded from a pH sensor. The results demonstrate satisfying functionality, area, and power constraints even when a degree of programmability is incorporated in the system

A system-on-chip digital pH meter for use in a wireless diagnostic capsule

This paper describes the design and implementation of a system-on-chip digital pH meter, for use in a wireless capsule application. The system is organized around an 8-bit microcontroller, designed to be functionally identical to the Motorola 6805. The analog subsystem contains a floating-electrode ISFET, which is fully compatible with a commercial CMOS process. On-chip programmable voltage references and multiplexors permit flexibility with the minimum of external connections. The chip is designed in a modular fashion to facilitate verification and component re-use. The single-chip pH meter can be directly connected to a personal computer, and gives a response of 37 bits/pH, within an operating range of 7 pH units

Radiation from ingested wireless devices in bio-medical telemetry bands

The performance of wireless devices, using electrically small antennae, in the human intestine is investigated using the finite difference time domain method in recommended biomedical device telemetry bands. The radiation field intensity was found to depend on position but more strongly on frequency, with a transmission peak at 650 MHz

Tunable photonic crystal filter for terahertz frequency applications

In this Paper we investigate a tunable metallic photonic crystal filter with a novel mechanical tuning method, suitable for use in terahertz frequency applications. Tuning has been demonstrated in a micrometer-driven prototype at 70 - 110 GHz in accordance with rigorous full-vector electromagnetic simulations (finite-difference time-domain). The measured pass band has a Q of 11 and can be tuned over a 3.5 GHz range. The insertion loss is only 1.1 to 1.7 dB, while the stop band attenuation is >10 dB. The filter has the advantages of inexpensive, robust and compact construction and tunable operation that readily scales to any desired terahertz frequency

Calculated and measured transmittance of a tunable metallic photonic crystal filter for terahertz frequencies

A tunable metallic photonic crystal filter with a mechanical tuning mechanism is demonstrated. The performance is predicted with rigorous full-vector electromagnetic simulations (finite-difference time domain). A prototype has been built and characterized in the W band (70–110 GHz) using a vector network analyzer configured for free-space measurement of S parameters. The measured filter's passband has a quality factor of 11, a tuning range of 3.5 GHz, and insertion loss of only 1.1–1.7 dB. Device fabrication is straightforward, yielding an inexpensive, robust and compact tunable filter

In situ characterization of two wireless transmission schemes for ingestible capsules

We report the experimental in situ characterization of 30-40 MHz and 868 MHz wireless transmission schemes for ingestible capsules, in porcine carcasses. This includes a detailed study of the performance of a magnetically coupled near-field very high-frequency (VHF) transmission scheme that requires only one eighth of the volume and one quarter of the power consumption of existing 868-MHz solutions. Our in situ measurements tested the performance of four different capsules specially constructed for this study (two variants of each transmission scheme), in two scenarios. One mimicked the performance of a body-worn receiving coil, while the other allowed the characterization of the direction-dependent signal attenuation due to losses in the surrounding tissue. We found that the magnetically coupled near-field VHF telemetry scheme presents an attractive option for future, miniturized ingestible capsules for medical applications

Electromagnetic radiation from ingested sources in the human intestine

There is currently considerable work on the development of wireless sensors that can be used in the small intestine. The radiation characteristics of sources in the gastro-intestinal (GI) tract cannot be readily calculated due to the complexity of the human body and its composite tissues, each with different electrical characteristics. This paper presents radiation characteristics for sources in the GI tract that should allow for the optimum design of more efficient telemetry systems. The characteristics are determined using the finite difference time domain method with a realistic antenna model on an established fully segmented human body model. Maximum radiation was found to occur between 450 and 900 MHz and the gut region was found generally to inhibit vertically polarized electric fields more than horizontally polarized fields

Artificial dielectric devices for variable polarization compensation at millimeter and submillimeter wavelengths

Variable polarization compensation has been demonstrated at 100 GHz. The device consists of two interlocking V-groove artificial dielectric gratings that produce a birefringence that varies with the separation distance. A maximum retardance of 74/spl deg/ has been obtained experimentally in a silicon device, in good agreement with rigorous coupled-wave computer simulations. Further simulations predict that adding quarter wave dielectric antireflection (AR) coatings to the outer surfaces of the device can reduce the insertion loss to below 4 dB. The use of rectangular grooved gratings provides increased retardance and reduced loss. It is predicted that a coupled device with rectangular grooved gratings will be capable of maximum retardance in excess of 180/spl deg/, with low insertion loss (<0.6 dB). The sensitivity of the wave retardation as a function of mechanical separation has a peak value of 485/spl deg//mm. The design and micromachining fabrication techniques scale for operation at submillimeter wavelengths

Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz

The conventional method of diagnosing disorders of the human gastro-intestinal (GI) tract is by sensors embedded in cannulae that are inserted through the anus, mouth, or nose. However, these cannulae cause significant patient discomfort and cannot be used in the small intestine. As a result, there is considerable ongoing work in developing wireless sensors that can be used in the small intestine. The radiation characteristics of sources in the GI tract cannot be readily calculated due to the complexity of the human body and its composite tissues, each with different electrical characteristics. In addition, the compact antennas used are electrically small, making them inefficient radiators. This paper presents radiation characteristics for sources in the GI tract that should allow for the optimum design of more efficient telemetry systems. The characteristics are determined using the finite-difference time-domain method with a realistic antenna model on an established fully segmented human body model. Radiation intensity outside the body was found to have a Gaussian-form relationship with frequency. Maximum radiation occurs between 450 and 900 MHz. The gut region was found generally to inhibit vertically polarized electric fields more than horizontally polarized fields