<i>N</i>,<i>N</i>‑Dimethylformamide (DMF) as a Source of Oxygen To Access α‑Hydroxy Arones via the α‑Hydroxylation of Arones

An unprecedented α-hydroxylation strategy was developed for the synthesis of α-hydroxy arones using <i>N</i>,<i>N</i>-dimethylformamide (DMF) as an oxygen source. Control experiments demonstrated that the oxygen atom of the hydroxy group in the α-hydroxy arones produced in this reaction was derived from DMF. This new reaction therefore not only provides an alternative strategy for the α-hydroxylation of arones but also highlights the possibility of using the inexpensive common solvent DMF as a source of oxygen in organic synthesis

Preparation of 1,2-Oxazetidines from Styrenes and Arylamines via a Peroxide-Mediated [2 + 1 + 1] Cycloaddition Reaction

The first regioselective synthesis of polysubstituted 1,2-oxazetidines, based on the [2 + 1 + 1] radical tandem cycloaddition of styrenes, arylamines, and <i>tert</i>-butyl hydroperoxide (TBHP), is described. This simple and direct method allows the synthesis of 1,2-oxazetidines with a broad substrate scope from easily accessible materials. TBHP was employed in this conversion not only as the oxidant but also as the source of “O” for the carbonyl group in the products

Association of GPS with characteristics of patients.

<p>Association of GPS with characteristics of patients.</p

Comparison of overall survival according to scoring systems, GPS (A), NLR (B) and PLR (C).

<p>Comparison of overall survival according to scoring systems, GPS (A), NLR (B) and PLR (C).</p

Univariate and Multivariate Analysis of Prognostic Factors of Overall Survival.

<p>Univariate and Multivariate Analysis of Prognostic Factors of Overall Survival.</p

Kaplan–Meier estimates for progression-free survival according to GPS.

<p>Kaplan–Meier estimates for progression-free survival according to GPS.</p

Univariate and Multivariate Analysis of Prognostic Factors of Progression-free Survival.

<p>Univariate and Multivariate Analysis of Prognostic Factors of Progression-free Survival.</p

Comparisons of the area under the receiver operating curve for survival status between scoring systems at 6 month (A), 12 month (B) and 24 month (C).

<p>Comparisons of the area under the receiver operating curve for survival status between scoring systems at 6 month (A), 12 month (B) and 24 month (C).</p

Additional file 1: Table S1. of Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

The clinicopathologic characteristics of the 112 GC patients who received surgery followed by adjuvant chemotherapy in this study. (DOC 40 kb

Kaplan–Meier estimates for overall survival according to serum HER 2 ECD levels and tissue HER 2 status.

<p>Serum HER 2 ECD levels showed no association with overall survival. Whereas positive tissue HER 2 status was significantly associated with worse overall survival.</p