Evolution of the measures related with the primary outcome measure (the BAT) in both treatment conditions.

<p>Evolution of the measures related with the primary outcome measure (the BAT) in both treatment conditions.</p

Descriptive data about demographic variables, diagnosis, phobia’s duration, and medication.

<p>Descriptive data about demographic variables, diagnosis, phobia’s duration, and medication.</p

Flow diagram of study participants, point of random assignment, and dropouts in each stage of the study.

<p>Flow diagram of study participants, point of random assignment, and dropouts in each stage of the study.</p

A participant exposed to real cockroaches.

<p>A participant exposed to real cockroaches.</p

Types of spiders available into the AR system.

<p>Types of spiders available into the AR system.</p

Additional file 1: of The effectiveness of ICT-based neurocognitive and psychosocial rehabilitation programmes in people with mild dementia and mild cognitive impairment using GRADIOR and ehcoBUTLER: study protocol for a randomised controlled trial

SPIRIT Checklist. Recommended items to address in a clinical trial protocol and related documents. (DOC 120 kb

Additional file 1: of An Internet-based treatment for flying phobia (NO-FEAR Airlines): study protocol for a randomized controlled trial

SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (DOCX 61 kb

Endocannabinoid and related compounds plasma concentrations.

<p>Box plots of plasma concentrations of 2-arachidonoyl glycerol (A), anandamide (B), 2-linoleoylglycerol (C), docosahexaenoylethanolamide (D), 2-oleoylglycerol (E), oleoylethanolamide (F), linoleoylethanolamide (G), and palmitoylethanolamide (H) of subjects from each of the body mass index (BMI) sub-groups. The median is represented as a line within the box plot and the mean is represented as a + sign. Significant differences (p<0.05) of endocannabinoids and related compounds concentrations between BMI subgroups are represented by asterisks (*).</p

Cost-utility planes.

<p>Fig 2a. Scatterplot TSG vs. iTAU. Fig 2b. Scatterplot LITG vs. iTAU. QALY: quality-adjusted life year.</p

CONSORT flowchart of the participants in the economic evaluation.

<p>iTAU: improved treatment as usual; TSG: totally self-guided Internet-based program; LITG: low-intensity therapist-guided Internet-based program.</p