Contribution of <i>UCP3</i> to BMI, percentage of lean body mass (%LBM), and percentage of mass (%FM).

<p>Contribution of <i>UCP3</i> to BMI, percentage of lean body mass (%LBM), and percentage of mass (%FM).</p

Substrate oxidation in patients submitted to bariatric surgery before and six months after the surgery and in the control group.

<p>A: lipid oxidation, B: carbohydrate oxidation, C: lipid + carbohydrate (lip + cho). Preop: preoperatively, Postop: postoperatively. *p < 0.05 Group 2 as compared to Group 1 Preop and Group 1 Postop.</p

Contribution of <i>UCP1</i> and <i>UCP3</i> expression to lipid and carbohydrate oxidation.

<p>Contribution of <i>UCP1</i> and <i>UCP3</i> expression to lipid and carbohydrate oxidation.</p

Anthropometry, body composition, and respiratory variables in grade III obese patients before and after (six months postoperatively) bariatric surgery (Group 1) and normal-weight individuals (Group 2).

<p>Anthropometry, body composition, and respiratory variables in grade III obese patients before and after (six months postoperatively) bariatric surgery (Group 1) and normal-weight individuals (Group 2).</p

<i>UCP1</i> and <i>UCP3</i> Expression Is Associated with Lipid and Carbohydrate Oxidation and Body Composition

<div><p>Background/Objective</p><p>Uncoupling proteins (<i>UCPs</i>) are located in the inner membrane of mitochondria. These proteins participate in thermogenesis and energy expenditure. This study aimed to evaluate how <i>UCP1</i> and <i>UCP3</i> expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery.</p><p>Subjects/Methods</p><p>This is a longitudinal study comprising 13 women with obesity grade III that underwent bariatric surgery and 10 healthy weight individuals (control group). Body composition was assessed by bioelectrical impedance. Carbohydrate and fat oxidation was determined by indirect calorimetry. Subcutaneous adipose tissue was collected for gene expression analysis. QPCR was used to evaluate <i>UCP1</i> and <i>UCP3</i> expression.</p><p>Results</p><p>Obese patients and the control group differed significantly in terms of lipid and carbohydrate oxidation. Six months after bariatric surgery, the differences disappeared. Lipid oxidation correlated with the percentage of fat mass in the postoperative period. Multiple linear regression analysis showed that the <i>UCP1</i> and <i>UCP3</i> genes contributed to lipid and carbohydrate oxidation. Additionally, <i>UCP3</i> expression was associated with BMI, percentage of lean body mass, and percentage of mass in the postoperative period.</p><p>Conclusions</p><p><i>UCP1</i> and <i>UCP3</i> expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery. In addition, <i>UCP3</i> participates in body composition modulation six months postoperatively.</p></div

Correlation between lipid oxidation and percentage of fat mass.

<p>A: Preoperatively, B: Postoperatively.</p

Relative gene expression in obese women preoperatively and six months after bariatric surgery.

<p>A: <i>UCP1</i>, B: <i>UCP3</i>.</p