Associations between high affinity^‡ SSRI use and RV measures in limited and adjusted models, stratified by sex for RV mass and RVEDV.

<p>*Adjusted for age, sex, race/ethnicity, height, weight, and level of education.</p>†<p>Adjusted for age, sex, race/ethnicity, height, weight, level of education, depression (Center for Epidemiologic Studies Depression-Scale (CES-D) ≥16), smoking (status and pack-years), hypertension, systolic and diastolic blood pressure, cholesterol, low-density lipoprotein levels, triglycerides, and statin use.</p>‡<p>Fluoxetine, fluvoxamine, paroxetine, and sertraline.</p

Associations between SSRI use and RV measures in limited and adjusted models, stratified by sex for RV mass and RVEDV.

<p>*Adjusted for age, sex, race/ethnicity, height, weight, and level of education.</p>†<p>Adjusted for age, sex, race/ethnicity, height, weight, level of education, depression (Center for Epidemiologic Studies.</p><p>Depression-Scale (CES-D) ≥16), smoking (status and pack-years), hypertension, systolic and diastolic blood pressure, cholesterol, low-density lipoprotein levels, triglycerides, and statin use.</p

Study sample.

<p>MESA: Multi-Ethnic Study of Atherosclerosis; MRI: magnetic resonance imaging; LV: left ventricle; RV: right ventricle.</p

Characteristics of the study sample and of those participants excluded.

<p>Data shown as mean ± standard deviation or %. Percentages may not add to one because of rounding.</p><p>*Citalopram.</p>†<p>Fluoxetine, fluvoxamine, paroxetine, and sertraline.</p>‡<p>Includes atypical (bupropion), monoamine oxidase inhibitors, tetracyclic (mirtazapine), and serotonin antagonist and reuptake inhibitor (trazodone and nefazodone) antidepressants.</p

Associations between sex and hemodynamics in pulmonary hypertension^* cohort and precapillary pulmonary hypertension subgroup after multivariable adjustment^‡.

<p>Associations between sex and hemodynamics in pulmonary hypertension^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187734#t004fn002" target="_blank">*</a>} cohort and precapillary pulmonary hypertension subgroup after multivariable adjustment^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187734#t004fn004" target="_blank">‡</a>}.</p

Unadjusted hemodynamic variables for pulmonary hypertension cohort and precapillary pulmonary hypertension subgroup, by sex.

<p>Unadjusted hemodynamic variables for pulmonary hypertension cohort and precapillary pulmonary hypertension subgroup, by sex.</p

Characteristics of the subgroup with precapillary pulmonary hypertension^†, by sex.

<p>Characteristics of the subgroup with precapillary pulmonary hypertension^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187734#t002fn001" target="_blank">†</a>}, by sex.</p

Characteristics of the total cohort with pulmonary hypertension^*, by sex.

<p>Characteristics of the total cohort with pulmonary hypertension^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187734#t001fn001" target="_blank">*</a>}, by sex.</p

Kaplan-Meier curve for cohort of subjects with precapillary pulmonary hypertension (PH) by sex.

<p>Dotted line is women, solid line is men.</p