Особливості імуно-гормонального та мікробіологічного статусу у жінок з різними морфологічними формами поліпів ендометрія

Обследовано 58 женщин с полипами эндометрия. Выявлены особенности микробиологического пейзажа, гормонального и иммунного статуса в зависимости от морфологических форм полипов эндометрия. проведенный анализ позволил выделить группы риска по развитию полипов эндометрия. показано, что полип эндометрия следует рассматривать не как местный процесс, а как реакцию эндометрия в ответ на повреждение гормонального и иммунного гомеостаза, что необходимо учитывать при выборе лечения данной патологии58 women with endometrial polyps were investigated. Specific microflora and hormonal and immune status depending on the morphological forms of endometrial polyps were found. The analysis performed allowed to allocate risk groups according to development of endometrial polyp. It was shown that endometrial polyp shall be considered as endometrial reaction in response to hormonal and immune homeostasis disorder, rather than local process. This should be borne in mind when choosing treatment for this patholog

Pharmacogenetics in clinical practice

The availability of data from pharmacogenetic studies is reflected in therapeutic practice, and pharmacogenetics is slowly entering the medical arena. Preconditions for the utilisation of pharmacogenetic knowledge are that: 1) genetic variation and prevalence are known 2) pharmacological consequences (concerning efficacy or toxicity) are known 3) clinical relevance is demonstrated 4) data from pharmacogenetic studies are translated in to practical guidelines 5) knowledge and techniques are available. Tasks and responsibilities should be clearly set out regarding the request for pharmacogenetic analysis, the pharmacogenetic analysis itself, interpretation of the results and advice to the medical practitioner. The advice to give or not to give a drug to a patient, or to adjust drug dose or frequency, cannot be based exclusively on someone's genotype, but is the result of several factors. These include age, sex, weight, liver and renal function, concomitant medication, drug blood levels, serum albumin and protein binding, whether the patient smokes, nutrition and genetic factors (a combination of several genotypes). Pharmacogenetics will be an important and useful tool for individualising pharmacotherapy in the near future, as is therapeutic drug monitoring at present. The first examples of pharmacogenetic knowledge in medical practice are already in use