Prisoners of pleasure? by David Concar

People will abuse anything from cream cakes to crack. What can or should a society do about it in the face of escalating addiction? Can we ever hope to understand what makes some of us turn to drugs

How to heal the body's craving. by Rosie Mestel and David Concar

No one knows whether drug addicts ever find permanent relief. An investigation of the latest methods for treating addiction

The highs & lows of prohibition. by David Concar and Laura Spinney

As drug-related crime soars, so calls to legalise drugs become more vociferous. But waht would that do to the cost of healthcare

Investigation of the solution structures and mobility of oxidised and reduced cytochrome b5 by 2D NMR spectroscopy

AbstractTwo dimensional 1H NMR spectroscopy is used to examine the structure and mobility of cytochrome b5 in solution. The assignment of many residues and the interpretation of nuclear Overhauser effects (NOEs) in both redox states allow definition of secondary structural elements. Comparison with X-ray diffraction data shows that differences between crystal and solution structures are small. The dynamics of the protein are examined and the protein is shown to be more mobile than cytochrome c. The relationship of the structure and dynamics to the electron transfer function of cytochrome b5 is discussed