57 research outputs found
Chemically modified field effect transistors: the effect of ion-pair association on the membrane potentials
A theoretical model has been developed which relates physically accessible parameters to the formation of a membrane potential. The description is an extension of a theoretical description presented previously by our group, now including divalent cations and ion-pair association. Simulations of the overall membrane potential reveal several factors that may lead to non-Nernstian response curves. For monovalent and divalent cations a reduction in the slope of the response curve (sub-Nernstian response) should virtually always be expected when ion-pair association takes place in the membrane. Ion-pair association of divalent cations and sample anions can lead to a super-Nernstian response. A diffusion potential generally reduces the Nernstian slope of the response curve. In addition, several experimental results are described which illustrate and confirm our theoretical model
Home mechanical ventilatio:the Dutch approach
In the Netherlands we have an unique organisation of only 4 centres being responsible for all patients who need Home Mechanical ventilation(HMV). Nationwide criteria for referral and initiation of HMV are stated in our national guideline and recently a unique national learning management system (LMS) for all caregivers and professionals was developed. A nationwide multi-centric research program is running and every centre is participating. In this paper we provide information about the evolution of HMV in the Netherlands during the last 30 years, including details about the number of patients, different diagnose groups, residence and the type of ventilators
Quantification of SMN protein in leucocytes from spinal muscular atrophy patients: effects of treatment with valproic acid
An updated evaluation of the implementation of the sigmoid take-off landmark 1Â year after the official introduction in the Netherlands
Prenatal Diagnosis of Spinal Muscular Atrophy by Direct Molecular Analysis: Efficacy and Potential Pitfalls
A rare complex malformation of the hand in split hand foot malformation type 3 (SHFM3)
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Transduction of selective recognition of heavy metal ions by chemically modified field effect transistors (CHEMFETs)
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