6 research outputs found
Palladium-Catalyzed Aerobic Dehydrogenative Cross-Coupling of Polyfluoroarenes with Thiophenes: Facile Access to Polyfluoroarene–Thiophene Structure
We report a Pd-catalyzed aerobic dehydrogenative cross-coupling
of polyfluoroarenes with thiophenes via 2-fold C–H functionalization.
The advantages of this reaction are its high reaction efficiency,
excellent functional group compatibility, and use of molecular O<sub>2</sub> as terminal oxidant. This reaction provides a useful and
facile protocol for the preparation of polyfluoroarene–thiophene
structure of interest in functional materials. Mechanistic studies
revealed that the reaction is initiated by the C–H bond cleavage
of polyfluoroarenes
Direct (Het)Arylation of Fluorinated Benzothiadiazoles and Benzotriazole with (Het)Aryl Iodides
A new
and controllable method for the preparation of unsymmetrical and symmetrical
fluorinated benzothiadiazole (FBT)–arene structures that can
be applied in organic optoelectronic materials has been developed.
The reaction proceeds under mild reaction conditions with high efficiency
and shows excellent functional group compatibility, even toward bromide.
Fluorinated benzotriazoles also take part in the reaction
Pd-Catalyzed Dehydrogenative Cross-Coupling of Polyfluoroarenes with Heteroatom-Substituted Enones
The first example of intermolecular regioselective α-arylation of heteroatom-substituted enones with polyfluoroarenes via twofold C–H bond functionalization using a palladium catalyst is reported. This approach provides rapid access to a wide range of α-fluoroarylated enones of interest in life science
Efficient difluoromethylation of isoflavonoids and flavonoid under mild conditions
<p>A simple and efficient protocol for difluoromethylation of isoflavones, flavonoids, and coumarins has been developed. The protocol uses readily available, non-ozone-depleting and easy handling BrCF<sub>2</sub>PO(OEt)<sub>2</sub> as difluorocarbene precursor. The reaction underwent the formation of difluorocarbene under mild reaction conditions with relatively weak base therefore demonstrates high selectivity. Application of the reaction led to difluoromethylated biologically relevant molecules.</p
Pd-Catalyzed Dehydrogenative Cross-Coupling of Polyfluoroarenes with Heteroatom-Substituted Enones
The first example of intermolecular regioselective α-arylation of heteroatom-substituted enones with polyfluoroarenes via twofold C–H bond functionalization using a palladium catalyst is reported. This approach provides rapid access to a wide range of α-fluoroarylated enones of interest in life science
Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins
An efficient and general method for
the synthesis of difluoroalkylated
uracils, pyridinones, and coumarins through visible-light-induced
reaction with commercial materials is developed. The strategy proceeds
with high efficiency under mild reaction conditions and shows excellent
functional group compatibility, even toward bromide and hydroxyl group,
thus demonstrates high potent application in a late-stage fluoroalkylation.
Moreover, the difluoroalkylated products can be further transformed
to a diverse variety of difluoroalkylated heterocycles, including
molecules of potential biological activity