52 research outputs found

    Media 1: High-sensitivity dynamical profilometry with a fiber-based composite interferometer

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    Originally published in Optics Letters on 15 July 2013 (ol-38-14-2434

    Media 2: High-sensitivity dynamical profilometry with a fiber-based composite interferometer

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    Originally published in Optics Letters on 15 July 2013 (ol-38-14-2434

    One-Pot Organocatalytic Enantioselective Michael–Michael–Aldol–Henry Reaction Cascade. A Facile Entry to the Steroid System with Six Contiguous Stereogenic Centers

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    An expedited method has been developed for the enantioselective synthesis of highly functionalized steroid systems containing six contiguous stereogenic centers with high enantioselectivities (99% <i>ee</i>). The one-pot methodology comprises a cascade of organocatalytic Michael–Michael–aldol–Henry reactions of 7-nitrohept-3-en-2-one and 5-(1-methyl-2,5-dioxo­cyclo­pentyl)­pent-2-enal. The structure and absolute configuration of the products were confirmed by X-ray analyses of appropriate products

    One-Pot Organocatalytic Enantioselective Michael–Michael–Aldol–Henry Reaction Cascade. A Facile Entry to the Steroid System with Six Contiguous Stereogenic Centers

    No full text
    An expedited method has been developed for the enantioselective synthesis of highly functionalized steroid systems containing six contiguous stereogenic centers with high enantioselectivities (99% <i>ee</i>). The one-pot methodology comprises a cascade of organocatalytic Michael–Michael–aldol–Henry reactions of 7-nitrohept-3-en-2-one and 5-(1-methyl-2,5-dioxo­cyclo­pentyl)­pent-2-enal. The structure and absolute configuration of the products were confirmed by X-ray analyses of appropriate products

    Patient selection process.

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    Abbreviations: AMI = acute myocardial infarction; ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; CABG = coronary artery bypass; MPR = medication possession ratio.</p

    Incidence (per 1000 PM) and adjusted hazard risk of major outcomes for treatment efficiency based on as-treated analysis.

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    Incidence (per 1000 PM) and adjusted hazard risk of major outcomes for treatment efficiency based on as-treated analysis.</p

    Incidence (per 1000 PM) and adjusted hazard risk of the major outcomes for treatment efficiency based on intention-to-treat analysis.

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    Incidence (per 1000 PM) and adjusted hazard risk of the major outcomes for treatment efficiency based on intention-to-treat analysis.</p

    Changes in the use of renin-angiotensin system inhibitors after 3 months of index date.

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    Changes in the use of renin-angiotensin system inhibitors after 3 months of index date.</p
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