T‐cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level

Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL

Editorial : The molecular landscape and promising therapeutic targets in aggressive B-cell non-Hodgkin lymphomas

HW received support from Soldatentumorhilfe and Stefan-Morsch-Stiftung. NG was supported by Stefan-Morsch-Stiftung, the Damp-Stiftung, the Wilhelm-Sander-Stiftung, the Jose Carreras Leukämie-Stiftung. GR was supported by the Spanish Ministry of Science and Innovation (PID2021-123039OB-C21) and the Catalan Agency for Management of University and Research Grants (2021SGR01535)