Flow chart denoting the search procedure for this systematic review.

<p>This process was repeated multiple times between September 2015 and December 2015.</p

Collection of base miR groups containing putatively related, differentially expressed members across all included screening studies.

<p>Group which consisted solely of the same repeated exact miR entity (e.g. miR-181a) were removed. The miRs were grouped together into families using mirBASE and miRNAVISA. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160808#pone.0160808.s001" target="_blank">S1 File</a> for a full list of specific miRs belonging to these groups and study references.</p

List of differentially expressed miRs found in chorionic and/or basal plate regions of PE placentas.

<p>List of differentially expressed miRs found in chorionic and/or basal plate regions of PE placentas.</p

List of PE-associated miRs from included screening studies which were found to be differentially expressed in more than one independent study and validated by qRT-PCR.

<p>List of PE-associated miRs from included screening studies which were found to be differentially expressed in more than one independent study and validated by qRT-PCR.</p

Internal controls used for qRT-PCR (both array-based and stem-loop) across screening and candidate studies mainly consisted of the small nuclear RNA, U6.

<p>Internal controls used for qRT-PCR (both array-based and stem-loop) across screening and candidate studies mainly consisted of the small nuclear RNA, U6.</p

Flow chart depicting the systematic comparison of miRs across studies.

<p>Input data was collected from all studies included within the systematic review.</p

Charts depicting the included screening and candidate studies split by sample type.

<p>Some individual studies examined miR expression in multiple sample types.</p

List of studies detecting differential expression of miR-126* or miR-126, with their respective directions of change.

<p>List of studies detecting differential expression of miR-126* or miR-126, with their respective directions of change.</p

Overlapping results from SOLiD-based NGS screening studies.

<p>a) Profiling in placental samples with similar methodologies b) Profiling in circulatory (plasma/serum) samples c) Profiling across all sample types.</p

Sample size groups used across all included screening studies.

<p>Sample size groups used across all included screening studies.</p