16,220 research outputs found
Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster
Within a case study on the protein-protein interaction network (PIN) of
Drosophila melanogaster we investigate the relation between the network's
spectral properties and its structural features such as the prevalence of
specific subgraphs or duplicate nodes as a result of its evolutionary history.
The discrete part of the spectral density shows fingerprints of the PIN's
topological features including a preference for loop structures. Duplicate
nodes are another prominent feature of PINs and we discuss their representation
in the PIN's spectrum as well as their biological implications.Comment: 9 pages RevTeX including 8 figure
Study of an Alternate Mechanism for the Origin of Fermion Generations
In usual extended technicolor (ETC) theories based on the group
, the quarks of charge 2/3 and -1/3 and the charged
leptons of all generations arise from ETC fermion multiplets transforming
according to the fundamental representation. Here we investigate a different
idea for the origin of SM fermion generations, in which quarks and charged
leptons of different generations arise from ETC fermions transforming according
to different representations of . Although this
mechanism would have the potential, {\it a priori}, to allow a reduction in the
value of relative to conventional ETC models, we show that, at least
in simple models, it is excluded by the fact that the technicolor sector is not
asymptotically free or by the appearance of fermions with exotic quantum
numbers which are not observed.Comment: 6 pages, late
Bayesian inference on compact binary inspiral gravitational radiation signals in interferometric data
Presented is a description of a Markov chain Monte Carlo (MCMC) parameter
estimation routine for use with interferometric gravitational radiational data
in searches for binary neutron star inspiral signals. Five parameters
associated with the inspiral can be estimated, and summary statistics are
produced. Advanced MCMC methods were implemented, including importance
resampling and prior distributions based on detection probability, in order to
increase the efficiency of the code. An example is presented from an
application using realistic, albeit fictitious, data.Comment: submitted to Classical and Quantum Gravity. 14 pages, 5 figure
Universality of Electron Mobility in LaAlO/SrTiO and bulk SrTiO
Metallic LaAlO/SrTiO (LAO/STO) interfaces attract enormous attention,
but the relationship between the electron mobility and the sheet electron
density, , is poorly understood. Here we derive a simple expression for
the three-dimensional electron density near the interface, , as a
function of and find that the mobility for LAO/STO-based interfaces
depends on in the same way as it does for bulk doped STO. It is known
that undoped bulk STO is strongly compensated with background donors and acceptors. In intentionally doped
bulk STO with a concentration of electrons background impurities
determine the electron scattering. Thus, when it is natural to see
in LAO/STO the same mobility as in the bulk. On the other hand, in the bulk
samples with the mobility collapses because scattering happens on
intentionally introduced donors. For LAO/STO the polar catastrophe
which provides electrons is not supposed to provide equal number of random
donors and thus the mobility should be larger. The fact that the mobility is
still the same implies that for the LAO/STO the polar catastrophe model should
be revisited.Comment: 4 pages and 1 figur
ML-SIM: universal reconstruction of structured illumination microscopy images using transfer learning.
Structured illumination microscopy (SIM) has become an important technique for optical super-resolution imaging because it allows a doubling of image resolution at speeds compatible with live-cell imaging. However, the reconstruction of SIM images is often slow, prone to artefacts, and requires multiple parameter adjustments to reflect different hardware or experimental conditions. Here, we introduce a versatile reconstruction method, ML-SIM, which makes use of transfer learning to obtain a parameter-free model that generalises beyond the task of reconstructing data recorded by a specific imaging system for a specific sample type. We demonstrate the generality of the model and the high quality of the obtained reconstructions by application of ML-SIM on raw data obtained for multiple sample types acquired on distinct SIM microscopes. ML-SIM is an end-to-end deep residual neural network that is trained on an auxiliary domain consisting of simulated images, but is transferable to the target task of reconstructing experimental SIM images. By generating the training data to reflect challenging imaging conditions encountered in real systems, ML-SIM becomes robust to noise and irregularities in the illumination patterns of the raw SIM input frames. Since ML-SIM does not require the acquisition of experimental training data, the method can be efficiently adapted to any specific experimental SIM implementation. We compare the reconstruction quality enabled by ML-SIM with current state-of-the-art SIM reconstruction methods and demonstrate advantages in terms of generality and robustness to noise for both simulated and experimental inputs, thus making ML-SIM a useful alternative to traditional methods for challenging imaging conditions. Additionally, reconstruction of a SIM stack is accomplished in less than 200 ms on a modern graphics processing unit, enabling future applications for real-time imaging. Source code and ready-to-use software for the method are available at http://ML-SIM.github.io
Calcium imaging analysis - how far have we come?
Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed within labs and until relatively recently, software packages were not widely available between researchers. We will discuss some of the most popular methods for calcium imaging analysis that are now widely available and describe why these protocols are so effective. We will also describe some of the newest innovations in the field that are likely to benefit researchers, particularly as calcium imaging is often an inherently low signal-to-noise method. Although calcium imaging analysis has seen recent advances, particularly following the rise of machine learning, we will end by highlighting the outstanding requirements and questions that hinder further progress and pose the question of how far we have come in the past sixty years and what can be expected for future development in the field
Spin liquid in a single crystal of the frustrated diamond lattice antiferromagnet CoAl2O4
We study spin liquid in the frustrated diamond lattice antiferromagnet
CoAl2O4 by means of single crystal neutron scattering in zero and applied
magnetic field. The magnetically ordered phase appearing below TN=8 K remains
nonconventional down to 1.5 K. The magnetic Bragg peaks at the q=0 positions
remain broad and their profiles have strong Lorentzian contribution.
Additionally, they are connected by weak diffuse streaks along the
directions. These observations are explained within the spiral spin liquid
model as short-range magnetic correlations of spirals populated at these finite
temperatures, as the energy minimum around q=0 is flat and the energy of
excited states with q=(111) is low. The agreement is only qualitative, leading
us to suspect that microstructure effects are also important. Magnetic field
significantly perturbs spin correlations. The 1.5 K static magnetic moment
increases from 1.58 mB/Co at zero field to 2.08 mB/Co at 10 T, while the
magnetic peaks, being still broad, acquire almost Gaussian profile. Spin
excitations are rather conventional spin waves at zero field, resulting in the
exchange parameters J1=0.92(1) meV, J2=0.101(2) meV and the anisotropy term
D=-0.0089(2) meV for CoAl2O4. The application of a magnetic field leads to a
pronounced broadening of the excitations at the zone center, which at 10 T
appear gapless and nearly featureless
Using the average spectrum method to extract dynamics from quantum Monte Carlo simulations
We apply the Average Spectrum Method to the problem of getting the excitation
spectrum from imaginary-time quantum Monte Carlo simulations. We show that with
high quality QMC data this method reproduces the dominant spectral features
very well. It is also capable of giving information on the spectrum in regions
dominated by the many-particle continuum of excitations.Comment: v2: Major revision. Title and abstract as well as the focus of the
paper have been changed. Added a figure about the dynamics of 1D Heisenberg
chai
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