Helicopter main-rotor speed effects on far-field acoustic levels

The design of a helicopter is based on an understanding of many parameters and their interactions. For example, in the design stage of a helicopter, the weight, engine, and rotor speed must be considered along with the rotor geometry when considering helicopter operations. However, the relationship between the noise radiated from the helicopter and these parameters is not well understood, with only limited model and full-scale test data to study. In general, these data have shown that reduced rotor speeds result in reduced far-field noise levels. This paper reviews the status of a recent helicopter noise research project designed to provide experimental flight data to be used to better understand helicopter rotor-speed effects on far-field acoustic levels. Preliminary results are presented relative to tests conducted with a McDonnell Douglas model 500E helicopter operating with the rotor speed as the control variable over the range of 103% of the main-rotor speed (NR) to 75% NR, and with the forward speed maintained at a constant value of 80 knots

Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats

RATIONALE: Contextual control over drug relapse depends on the successful reconsolidation and retention of context-response-cocaine associations in long-term memory stores. The basolateral amygdala (BLA) plays a critical role in cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior; however, less is known about the cellular mechanisms of this phenomenon. OBJECTIVES: The present study evaluated the hypothesis that protein kinase A (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII) activation in the BLA is necessary for the reconsolidation of context-response-cocaine memories that promote subsequent drug context-induced cocaine-seeking behavior. METHODS: Rats were trained to lever-press for cocaine infusions in a distinct context, followed by extinction training in a different context. Rats were then briefly re-exposed to the previously cocaine-paired context or an unpaired context in order to reactivate cocaine-related contextual memories and initiate their reconsolidation or to provide a similar behavioral experience without explicit cocaine-related memory reactivation, respectively. Immediately after this session, rats received bilateral microinfusions of vehicle, the PKA inhibitor, Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt (Rp-cAMPS), or the CaMKII inhibitor, KN-93, into the BLA or the posterior caudate putamen (anatomical control region). Rats were then tested for cocaine-seeking behavior (responses on the previously cocaine-paired lever) in the cocaine-paired context and the extinction context. RESULTS: Intra-BLA infusion of Rp-cAMPS, but not KN-93, following cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory reactivation-dependent fashion. CONCLUSIONS: PKA, but not CaMKII, activation in the BLA is critical for cocaine memory re-stabilization processes that facilitate subsequent drug context-induced instrumental cocaine-seeking behavior