2 research outputs found
Effects of Topology and Ionic Strength on Double-Stranded DNA Confined in Nanoslits
We investigate experimentally the effects of electrostatic
interactions and topological constraints on DNA dynamics in nanoslit
confinement by studying the equilibrium shape and dynamics of single
linear and circular λ-DNA confined in a silicon/glass nanoslit.
Having examined the dependence of chain radius of gyration <i>R</i><sub>∥</sub>, shape asphericity <i>A</i>, and relaxation time τ on chain topology, slit height <i>h</i> (20–782 nm), and solvent ionic strength <i>I</i> (8.2–268.8 mM), it is found that the chain shape
becomes more aspherical as <i>h</i> and <i>I</i> decrease. Moreover, in strong sub-Kuhn length confinement, the DNA
relaxation time increases with decreasing <i>h</i> in a
smooth and broad transition. Our results provide experimental evidence
to confirm that the scaling exponents of radius of gyration and of
relaxation time are the same for linear and circular DNA and help
resolve conflicting observations of the qualitative dependencies of
chain radius of gyration and relaxation time in sub-Kuhn length slits
Customizable Optical and Biofunctional Properties of a Medical Lens Based on Chemical Vapor Deposition Encapsulation of Liquids
An
innovative intraocular lens (IOL) device was fabricated based
on a chemical vapor deposition encapsulation process using functionalized
poly-<i>p</i>-xylylenes. The advanced IOL device provides
noncompromised design parameters for both its optical and biological
properties. As an excellent optical device, it provides a high refractive
index and a tunable effective focal length that is realized by manipulating
the wetting properties of the encapsulated liquids; the device also
offers protection from UV radiation. As a key medical device, it exhibits
excellent biocompatibility and reduced postoperative calcification
through the intrinsic properties of poly-<i>p</i>-xylylenes.
In addition, these synergic functions are provided with precise surface
chemistry for location to a guided attachment or repellent properties
for eye epithelial cells, which is important in preventing device-associated
complications