Catalyst-free synthesis of amines from cyclic ketones and formamides in superheated water

<p>A novel and environmentally benign protocol for the synthesis of amines from cyclic ketones and formamides is demonstrated. The reaction proceeds under catalyst-free and superheated water conditions and yields range from poor to excellent.</p

Regio- and stereoselective co-iodination of olefins using NH₄I and Oxone

<p>A simple, efficient, and environmentally benign protocol for the synthesis of vicinal iodohydrins and iodoesters from olefins using NH₄I and Oxone in CH₃CN/H₂O (1:1) and dimethylformamide (DMF) / dimethylacetamide (DMA), respectively, without employing a catalyst at room temperature is described. Regio- and stereoselective iodohydroxylation and iodoesterification of various olefins with <i>anti</i> fashion, following Markonikov’s rule, was achieved and the corresponding products were obtained in good to excellent yields. In addition, 1,2-disubstituted olefins afforded excellent diastereoselectivity.</p