Identifying Connectome Module Patterns via New Balanced Multi-Graph Normalized Cut.

Computational tools for the analysis of complex biological networks are lacking in human connectome research. Especially, how to discover the brain network patterns shared by a group of subjects is a challenging computational neuroscience problem. Although some single graph clustering methods can be extended to solve the multi-graph cases, the discovered network patterns are often imbalanced, e.g. isolated points. To address these problems, we propose a novel indicator constrained and balanced multi-graph normalized cut method to identify the connectome module patterns from the connectivity brain networks of the targeted subject group. We evaluated our method by analyzing the weighted fiber connectivity networks

Effectiveness of chemotherapy using bortezomib combined with homoharringtonine and cytarabine in refractory or relapsed acute myeloid leukemia: a phase II, multicenter, prospective clinical trial

BackgroundRefractory/relapsed acute myeloid leukemia (R/R AML) has unsatisfactory outcomes even after allogeneic hematopoietic stem cell transplantation. Long-term survival is mainly influenced by complete remission (CR) rates after induction therapies.ObjectivesTo investigate CR/CR with incomplete hematologic recovery (CRi) rates and adverse events with a new induction therapy (bortezomib, homoharringtonine, and cytarabine [BHA]) for patients with R/R AML.MethodsWe enrolled 21 patients with R/R AML (median age, 42 [range, 30–62] years), who received BHA for remission induction (bortezomib, 1.3 mg/m2/day on days 1 and 4; homoharringtonine, 4 mg/m2/day for 5 days, and cytarabine, 1.5 g/m2/day for 5 days). CR and adverse events were assessed.ResultsAfter one course of BHA, the CR/CRi and partial remission rates were 38.1% and 14.3%, respectively, with an overall response rate (ORR) of 52.4% in 21 patients. 9 of 21 patients harbored FLT3-ITD or FLT3-TKD mutations, and achieved either CR/CRi or ORR of 66.7% (P=0.03) by comparison with that in R/R AML without FLT3 mutation. After induction therapy, consolidation chemotherapy or allogeneic hematopoietic stem cell transplantation led to a one-year overall survival of 27.8% in all patients. One-year relapse-free survival was 50% in 8 patients who had achieved CR/CRi after one course of BHA. During induction, non-hematologic adverse events (grade 3/4) commonly were infection (90.5%), hypokalemia (14.4%), hypocalcemia (14.3%), and mucositis (9.5%). In patients achieving CR, the median time to neutrophil count >0.5×109/L and time to platelet count >20×109/L were 15 (13–17) days and 13 (13–18) days, respectively.ConclusionBHA chemotherapy regimen was safe and tolerable to serve as an induction therapy for R/R AML, particularly with FLT3 mutation. The higher CR/CRi rate will give a clue to determine a potentialeffectiveness of BHA for AML patients carrying FLT3 mutation in a further investigation.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2000029841

Modeling and analysis of regenerative cooling channels for scramjet engine

This paper presents a CFD simulation analysis method for the regenerative cooling channel of a supercombustion ramjet engine, and performs three-dimensional modeling and analysis. The influences of inlet mass flow, inlet pressure, and inlet temperature on the flow and heat transfer characteristics of kerosene in the cooling channel were analyzed, and the conclusions are as follows: The larger the inlet mass flow, the lower the maximum wall temperature and oil temperature. The change trend of wall temperature is basically the same under different inlet pressure conditions, all of which increase violently first, then stabilize and then suddenly increase suddenly, then decrease almost to the outlet, and the temperature is almost the same under different conditions.As the inlet temperature decreases, the temperature difference between the wall surface and kerosene becomes larger, and the convective heat transfer coefficient gradually increases

Modeling and analysis of regenerative cooling channels for scramjet engine

This paper presents a CFD simulation analysis method for the regenerative cooling channel of a supercombustion ramjet engine, and performs three-dimensional modeling and analysis. The influences of inlet mass flow, inlet pressure, and inlet temperature on the flow and heat transfer characteristics of kerosene in the cooling channel were analyzed, and the conclusions are as follows: The larger the inlet mass flow, the lower the maximum wall temperature and oil temperature. The change trend of wall temperature is basically the same under different inlet pressure conditions, all of which increase violently first, then stabilize and then suddenly increase suddenly, then decrease almost to the outlet, and the temperature is almost the same under different conditions.As the inlet temperature decreases, the temperature difference between the wall surface and kerosene becomes larger, and the convective heat transfer coefficient gradually increases

The Application of Organic Phosphate Nucleating Agents in Polypropylene with Different Molecular Weights

Two kinds of organic phosphate nucleating agent (NA-11 and NA-21) were used in PP with different molecular weights through the melt extrusion method. The dispersibility of the nucleating agents in PP, and the effect of the nucleating agents on the molecular weight, rheological behavior and crystallization behavior of PP were investigated. SEM and TEM analysis showed that the average radius of the dispersed particles (nucleating agents) was larger in LPP than that in HPP. The good dispersion of NA-21 also created more nucleation embryos for the adsorption of polypropylene molecules than the agglomerated NA-11. The gel permeation chromatography (GPC) analysis showed that the average molecular weight of HPP and LPP both decreased with the addition of a nucleating agent. The rotational rheometer and capillary rheometer analysis showed that the effect of NA-21 on reducing intermolecular entanglement was more significant, whether in HPP or LPP. The addition of NA-21 had less elastic energy storage and better flow stability, and could be processed at a higher speed. Simultaneously, the relaxation time in the blends with LPP was shorter than that with HPP. It was found that the crystallinity and nucleation efficiency of HPP/nucleating agent blends increased remarkably, while there was a barely perceptible increase in LPP/nucleating agent blends

Preparation and Characterization of Water-Insoluble Gardenia Blue Pigment

Based on molecular simulations, the synthetic route of water-insoluble gardenia blue pigment was prepared by the reaction of genipin and L-Phenylalanine methyl ester hydrochloride. A highly purified pigment was obtained after extraction by chloroform and purification by silica gel column chromatography, and the value of color is up to 288. A study on the structural characteristics of the pigment was implemented with a scanning electron microscope, ultraviolet-visible spectrophotometer, Fourier transform infrared spectrometer, X-ray photoelectron spectrometer, and quatropde-time of flight mass spectrometer. The results showed that the surface of the pigment was largely smooth and spherical; The λmax was 607 nm, and the main functional groups include O-C=O, C=O, C-N, C=C, OH, and benzene ring; We detrained six different molecular weight and chemical structures of pigments and speculated the particular structures and formation mechanisms of three kinds of pigment, whose molecular weights are 690.1156, 720.1226, and 708.1246 Da, respectively. The pigment was only able to be dissolved in ethanol, methanol, acetone, ethyl acetate, and other strong polar organic solvents, but was not able to be dissolved in water, ethyl ether, petroleum ether, and other weak polar organic solvents. In terms of light and thermal stabilities, water-insoluble gardenia blue pigment is significantly better than water-soluble gardenia blue pigment (p < 0.05). When it is under direct light for 7 days or incubated at 80–120 °C for 24 h, the pigment residual rates were 74.90, 95.26, 88.27, and 87.72%, respectively

The Application of Organic Phosphate Nucleating Agents in Polypropylene with Different Molecular Weights

Two kinds of organic phosphate nucleating agent (NA-11 and NA-21) were used in PP with different molecular weights through the melt extrusion method. The dispersibility of the nucleating agents in PP, and the effect of the nucleating agents on the molecular weight, rheological behavior and crystallization behavior of PP were investigated. SEM and TEM analysis showed that the average radius of the dispersed particles (nucleating agents) was larger in LPP than that in HPP. The good dispersion of NA-21 also created more nucleation embryos for the adsorption of polypropylene molecules than the agglomerated NA-11. The gel permeation chromatography (GPC) analysis showed that the average molecular weight of HPP and LPP both decreased with the addition of a nucleating agent. The rotational rheometer and capillary rheometer analysis showed that the effect of NA-21 on reducing intermolecular entanglement was more significant, whether in HPP or LPP. The addition of NA-21 had less elastic energy storage and better flow stability, and could be processed at a higher speed. Simultaneously, the relaxation time in the blends with LPP was shorter than that with HPP. It was found that the crystallinity and nucleation efficiency of HPP/nucleating agent blends increased remarkably, while there was a barely perceptible increase in LPP/nucleating agent blends

Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery