Additional file 1: of Persons with disabilities as experts-by experience: using personal narratives to affect community attitudes in Kilifi, Kenya

Appendix 1. Pre-intervention guide and Post-intervention guide. (DOCX 14 kb

Additional file 1: of A contextually relevant approach to assessing health risk behavior in a rural sub-Saharan Africa setting: the Kilifi health risk behavior questionnaire

A summary of the scaling evaluation, test-retest reliability and behavioral prevalence at baseline (Time 1) and retest (Time 2) for the items in the Kilifi Health Risk Behavior Questionnaire (KRIBE-Q). The data summarizes the utilization of response categories (reported in percentage); the test-retest reliability (represented by Gwet’s AC1 coefficient); overall prevalence of behavior at baseline (Time1) (reported in percentage); and prevalence of behavior (reported in percentage) for the sub-sample (85) that completed the questionnaire at both phases. The summarized data comprises 60 out of the total 69 items on health behavior in the KRIBE-Q. (XLSX 14 kb

Additional file 2: of Prevalence, risk factors and behavioural and emotional comorbidity of acute seizures in young Kenyan children: a population-based study

Table S1. Definitions of seizures and medical terms; Table S2. Identification and classification of febrile and non-febrile causes of children with acute seizures based on the WHO's Integrated Management of Childhood Infections (IMCI); Table S3. Causes of acute seizures diagnosed by a clinician according to phenotype in preschool children; Table S4. Bivariate and multivariable results for the factors associated with acute seizures diagnosed by a clinician; Table S5. Association of acute seizures with continuous behavioural and emotional scores as the outcome/dependent variable; Table S6. Proportion of total effect of acute seizures on CBCL problems mediated by a co-diagnosis of epilepsy; Table S7. Risk factors associated with total behavioural and emotional comorbidity of acute seizures; Table S8. Risk factors for externalising problems in children with acute seizures; Table S9. Risk factors for internalising problems in children with acute seizures; Figure S1. Prevalence of acute seizures in preschool children by age group; Figure S2. The overlap of focal, repetitive and prolonged phenotypes of acute seizures in 221 preschool children. (DOCX 96 kb

Additional file 1: of Health care utilization and outpatient, out-of-pocket costs for active convulsive epilepsy in rural northeastern South Africa: a cross-sectional Survey

Questionnaire used for data collection, Agincourt 2010. (DOCX 153 kb

Additional file 1: of ‘Everyone has a secret they keep close to their hearts’: challenges faced by adolescents living with HIV infection at the Kenyan coast

Interview Guide. (DOC 41 kb

Haplotype Transmission Disequilibrium Test (TDT) of association with severe malaria in Gambian, Kenyan and Malawian child-parental trios.

<p>The table shows the common haplotypes (frequency higher than 5%) within each LD block identified in the gene, their frequency and the results of family-based test of association with severe malaria in the three populations of affected child-parental trios. Freq: frequency of the haplotype in trio parents. These are not unbiased estimates of the population frequencies. OR: Odds Ratio comparing the risk of the untransmitted versus the transmitted haplotype. All other abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004206#pone-0004206-t002" target="_blank">Table 2</a>.</p

The <i>IRF1</i> locus and Single Nucleotide Polymorphisms (SNPs) tested for association with severe malaria in child-parental trios.

<p>From top to bottom, the figure shows: human chromosome 5 with its G-banding patterns (black, grey and black bands) where the location of the 5q31.1 band is indicated; genes contained within a 642 kb segment of the 5q31.1 band known as the “Th2 cytokine cluster”; <i>IRF1</i> gene region, where the arrow indicates the direction of transcription, horizontal lines indicate intergenic regions, white boxes indicate 5′ and 3′ un-transcribed regions (UTR), black boxes indicate exons and diagonal lines indicate introns; SNPs that were tested for severe malaria in our study populations and their location with respect to the <i>IRF1</i> gene region. Coordinates quoted (Mb) are based on Ensembl release 40.</p

Linkage Disequilibrium (LD ) architecture of the <i>IRF1</i> locus in The Gambia, Kenya and Malawi.

<p>Typed single nucleotide polymorphisms (SNPs) are represented on the vertical axis and ordered by chromosome position as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004206#pone-0004206-t001" target="_blank">Table 1</a>. Diagonal lines in two directions link each SNP to each of the other 17 SNPs. The LD (Δ²) between each pair of markers is represented by diamonds of different colours (see legend). Δ² is a simple measure of correlation between markers and is calculated as follows: (f_AB f_ab−f_Ab f_aB)²/(f_A f_a f_B f_b), where f stands for frequency, A and a denote the alleles at the first marker, B and b denote the alleles at the second marker, Ab is the haplotype carrying the major allele for the first marker and the minor allele for the second marker and so on. Blocks 1 and 2 are set of markers in high LD identified within the gene using the HAPLOVIEW application <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004206#pone.0004206-Barrett1" target="_blank">[16]</a>.</p

Minor allele frequency of <i>HBB</i> and <i>IRF1</i> Single Nucleotide Polymorphisms (SNPs) in trio parents from The Gambia, Kenya and Malawi.

<p>The table shows the SNPs that have been genotyped in the affected child parental trio studies and their frequency in trio parents from The Gambia, Kenya and Malawi. These are not unbiased estimates of the population frequencies. Chr coord is the SNP chromosome coordinate (chromosome: base pair) based on Ensemble release 40. Location: location of the SNP with respect to the <i>HBB</i> or <i>IRF1</i> locus. Alleles: minor and major alleles (major allele is shown in brackets). MAF: Minor Allele Frequency in pedigree parents (The Gambia, N = 1100; Kenya, N = 408; Malawi, N = 404). StE: Standard Error of the MAF. MAF comparison: P-values of Yates corrected χ² Test for comparison of MAF between populations; a P-value<0.05 is considered statistically significant. G: The Gambia. K: Kenya. M: Malawi.</p

Single marker Transmission Disequilibrium Test (TDT) of association with severe malaria in Gambian, Kenyan and Malawian child-parental trios.

<p>The table shows the SNPs tested in association analysis with severe malaria and results of the TDT in the three populations of affected child-parental trios. Inform is the number of informative trios. OR: Odds Ratio comparing the risk of the minor vs major allele. LCL and UCL: Lower and Upper Confidence Limits of a 95% Confidence Interval respectively. TDT P: P-value for the family-based test of association. P-values<0.05 are shown in bold.</p