Additional file 1: of Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

Supplemental information. Supplemental Methods; Figure S1. Response of RPMI-8226 WT, BTZ/7 and BTZ/100 cells to bortezomib and other chemotherapeutic agent; Figure S2. Intra- and extracellular metabolite analysis of BTZ- and CFZ-resistant cell lines; Figure S3. Response to serine starvation of RPMI-8226 WT and BTZ/100 cells; Figure S4. Bortezomib resistance correlates to the expression of PHGDH; Table S1. Characteristics of multiple myeloma patients; Table S2. Upregulated metabolic enzymes in RPMI-8226 BTZ/100 and BTZ/7 cells compared to WT; Table S3. Downregulated metabolic enzymes in RPMI-8226 BTZ/100 and BTZ/7 cells compared to WT. (PDF 6298 kb