44 research outputs found
Possible scenarios for soft and semi-hard components structure in central hadron-hadron collisions in the TeV region
Possible scenarios in hh collisions in the TeV regions are discussed in full
phase space. It is shown that at such high energies one should expect strong
KNO scaling violation and a ln(s) increase of the average charged multiplicity
of the semi-hard component, resulting in a huge mini-jet production.Comment: 20 pages, 9 PS figures included, LaTeX2e with AMSmath, epsfi
Superposition effect and clan structure in forward-backward multiplicity correlations
The main purpose of this paper is to discuss the link between
forward-backward multiplicity correlations properties and the shape of the
corresponding final charged particle multiplicity distribution in various
classes of events in different collisions. It is shown that the same mechanism
which explains the shoulder effect and the H_n vs. n oscillations in charged
particle multiplicity distributions, i.e., the weighted superposition of
different classes of events with negative binomial properties, reproduces
within experimental errors also the forward-backward multiplicity correlation
strength in e+e- annihilation at LEP energy and allows interesting predictions
for pp collisions in the TeV energy region, to be tested at LHC, for instance
with the ALICE detector. We limit ourselves at present to study substructures
properties in hadron-hadron collisions and e+e- annihilation; they are examined
as ancillary examples in the conviction that their understanding might be
relevant also in other more complex cases.Comment: 16 page
Scaling violations: Connections between elastic and inelastic hadron scattering in a geometrical approach
Starting from a short range expansion of the inelastic overlap function,
capable of describing quite well the elastic pp and scattering data,
we obtain extensions to the inelastic channel, through unitarity and an impact
parameter approach. Based on geometrical arguments we infer some
characteristics of the elementary hadronic process and this allows an excellent
description of the inclusive multiplicity distributions in and
collisions. With this approach we quantitatively correlate the violations of
both geometrical and KNO scaling in an analytical way. The physical picture
from both channels is that the geometrical evolution of the hadronic
constituents is principally reponsible for the energy dependence of the
physical quantities rather than the dynamical (elementary) interaction itself.Comment: 16 pages, aps-revtex, 11 figure
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
BACKGROUND: Despite treatment, there is often a higher incidence of cardiovascular complications in patients with hypertension than in normotensive individuals. Inadequate reduction of their blood pressure is a likely cause, but the optimum target blood pressure is not known. The impact of acetylsalicylic acid (aspirin) has never been investigated in patients with hypertension. We aimed to assess the optimum target diastolic blood pressure and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension. METHODS: 18790 patients, from 26 countries, aged 50-80 years (mean 61.5 years) with hypertension and diastolic blood pressure between 100 mm Hg and 115 mm Hg (mean 105 mm Hg) were randomly assigned a target diastolic blood pressure. 6264 patients were allocated to the target pressure < or =90 mm Hg, 6264 to < or =85 mm Hg, and 6262 to < or =80 mm Hg. Felodipine was given as baseline therapy with the addition of other agents, according to a five-step regimen. In addition, 9399 patients were randomly assigned 75 mg/day acetylsalicylic acid (Bamycor, Astra) and 9391 patients were assigned placebo. FINDINGS: Diastolic blood pressure was reduced by 20.3 mm Hg, 22.3 mm Hg, and 24.3 mm Hg, in the < or =90 mm Hg, < or =85 mm Hg, and < or =80 mm Hg target groups, respectively. The lowest incidence of major cardiovascular events occurred at a mean achieved diastolic blood pressure of 82.6 mm Hg; the lowest risk of cardiovascular mortality occurred at 86.5 mm Hg. Further reduction below these blood pressures was safe. In patients with diabetes mellitus there was a 51% reduction in major cardiovascular events in target group < or =80 mm Hg compared with target group < or =90 mm Hg (p for trend=0.005). Acetylsalicylic acid reduced major cardiovascular events by 15% (p=0.03) and all myocardial infarction by 36% (p=0.002), with no effect on stroke. There were seven fatal bleeds in the acetylsalicylic acid group and eight in the placebo group, and 129 versus 70 non-fatal major bleeds in the two groups, respectively (p<0.001). INTERPRETATION: Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events. The HOT Study shows the benefits of lowering the diastolic blood pressure down to 82.6 mm Hg. Acetylsalicylic acid significantly reduced major cardiovascular events with the greatest benefit seen in all myocardial infarction. There was no effect on the incidence of stroke or fatal bleeds, but non-fatal major bleeds were twice as common