203 research outputs found

    Make It Real - Undergraduate Research Opportunities

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    Theme one in the Quest for Distinction is for VCU to become a leader among national research universities in providing all students with high quality learning/living experiences focused on inquiry, discovery, and innovation in a global environment. Quest is grounded in a commitment to providing students with a diversity of experiences which are available at a premiere public research university. The goal of this project is to take advantage of the wealth of research resources at the Medical College of Virginia Campus, coordinate cross campus efforts to facilitate the use of these resources and increase faculty participation in mentoring undergraduate research projects

    Using the Galileo Solid-State Imaging Instrument as a Sensor of Jovian Energetic Electrons

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    We quantitatively describe the Jovian energetic electron environment using the Solid State Imager (SSI) on the Galileo spacecraft. We post-process raw SSI images by removing the target object and dark current to obtain frames only with the radiation contribution. The camera settings (gain state, filter, etc.) are used to compute the energy deposited in each pixel, which corresponds to the intensity of the observed radiation hits (the actual measurements are expressed with the digital number (DN), from which the energy deposited can be computed). Histograms of the number of pixels versus energy deposited by incident particles from processed SSI images are compared with the results from 3D Monte Carlo transport simulations of the SSI using Geant4. We use Geant4 to simulate the response of the SSI instrument to mono-energetic electron environments from 1 to 100 MeV. We fit the modeled instrument response to the SSI data using a linear combination of the simulated mono-energetic histograms to match the SSI observations. We then estimate the spectra of the energetic electron environment at Jupiter, or we estimate the integral flux when there is lower confidence in the spectra fits. We validate the SSI results by comparing the environment predictions to the observations from the Energetic Particle Detector (EPD) on the Galileo spacecraft, examining the electron differential fluxes from 10’s of keV to 11 MeV. For higher energies (up to 31.0 MeV), we compare our findings with the NASA GIRE model, which is based on measurements from the Pioneer spacecraft. This approach could be applied to other sets of imaging data in energetic electron environments, such as from star trackers in geostationary Earth orbits.Funding for A. Carlton’s work is provided by a NASA Space Technology Research Fellowship (NNX16AM74H)

    Useful to Usable: Developing Usable Climate Science for Agriculture

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    The Useful to Usable (U2U) project was a six-year research and extension project funded by the United States Department of Agriculture to provide both useful and usable climate information for the agricultural (corn) sector in the Midwestern United States. The project adopted an extensive co-production of knowledge and decision-making approach that involved intense iteration with potential end-users, including farmers and a variety of pro- fessional agricultural advisors, through focus groups and surveys, feedback at outreach events, and frequent informal interactions to develop both decision support tools and delivery mechanisms that met stakeholder needs. This overview paper for this special issue illustrates some key ways that the co-production process informed the overall project. Subsequent papers in the special issue span the different objectives of the U2U project, including social, climate, and agronomic sciences. A brief overview of these papers is pre- sented here

    Microscopic-observation drug-susceptibility assay for the diagnosis of TB.

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    BACKGROUND: New diagnostic tools are urgently needed to interrupt the transmission of tuberculosis and multidrug-resistant tuberculosis. Rapid, sensitive detection of tuberculosis and multidrug-resistant tuberculosis in sputum has been demonstrated in proof-of-principle studies of the microscopic-observation drug-susceptibility (MODS) assay, in which broth cultures are examined microscopically to detect characteristic growth. METHODS: In an operational setting in Peru, we investigated the performance of the MODS assay for culture and drug-susceptibility testing in three target groups: unselected patients with suspected tuberculosis, prescreened patients at high risk for tuberculosis or multidrug-resistant tuberculosis, and unselected hospitalized patients infected with the human immunodeficiency virus. We compared the MODS assay head-to-head with two reference methods: automated mycobacterial culture and culture on Löwenstein-Jensen medium with the proportion method. RESULTS: Of 3760 sputum samples, 401 (10.7%) yielded cultures positive for Mycobacterium tuberculosis. Sensitivity of detection was 97.8% for MODS culture, 89.0% for automated mycobacterial culture, and 84.0% for Löwenstein-Jensen culture (P<0.001); the median time to culture positivity was 7 days, 13 days, and 26 days, respectively (P<0.001), and the median time to the results of susceptibility tests was 7 days, 22 days, and 68 days, respectively. The incremental benefit of a second MODS culture was minimal, particularly in patients at high risk for tuberculosis or multidrug-resistant tuberculosis. Agreement between MODS and the reference standard for susceptibility was 100% for rifampin, 97% for isoniazid, 99% for rifampin and isoniazid (combined results for multidrug resistance), 95% for ethambutol, and 92% for streptomycin (kappa values, 1.0, 0.89, 0.93, 0.71, and 0.72, respectively). CONCLUSIONS: A single MODS culture of a sputum sample offers more rapid and sensitive detection of tuberculosis and multidrug-resistant tuberculosis than the existing gold-standard methods used

    Manual for implementation or modification of child vision and hearing screening programmes:EUSCREEN

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    The euscreen study aimed to compare vision and hearing screening programmes for children in all EU states by using a cost-effectiveness model. The cost-effectiveness model predicts the most cost-effective and affordable way to screen children in each country, given the local circumstances. Representatives of countries in Europe were asked to provide detailed data on the following domains: demography, the general background of screening systems, existing screening systems, coverage/attendance, tests used, follow-up/diagnosis, treatment, benefits and adverse effects. Paediatric ophthalmologists, paediatric otolaryngologists, audiologists and professionals who organise and perform screening in each country were invited to participate in the study and report on the state of screening in their country. An extensive, detailed questionnaire was developed for that purpose. Screening programmes have been tested in the county of Cluj in Romania for vision, and in three counties in Albania for hearing screening. This manual for implementation or modification of child vision and hearing screening programmes was developed by detailed tracking, and from identified requisites, facilitators and barriers. The cost-effectiveness model and this manual for implementation will assist healthcare providers and policy makers worldwide in their decisions to introduce or modify vision and hearing screening programmes, and increase effectiveness, efficiency and equity of child healthcar

    Manual for implementation or modification of child vision and hearing screening programmes:EUSCREEN

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    The euscreen study aimed to compare vision and hearing screening programmes for children in all EU states by using a cost-effectiveness model. The cost-effectiveness model predicts the most cost-effective and affordable way to screen children in each country, given the local circumstances. Representatives of countries in Europe were asked to provide detailed data on the following domains: demography, the general background of screening systems, existing screening systems, coverage/attendance, tests used, follow-up/diagnosis, treatment, benefits and adverse effects. Paediatric ophthalmologists, paediatric otolaryngologists, audiologists and professionals who organise and perform screening in each country were invited to participate in the study and report on the state of screening in their country. An extensive, detailed questionnaire was developed for that purpose. Screening programmes have been tested in the county of Cluj in Romania for vision, and in three counties in Albania for hearing screening. This manual for implementation or modification of child vision and hearing screening programmes was developed by detailed tracking, and from identified requisites, facilitators and barriers. The cost-effectiveness model and this manual for implementation will assist healthcare providers and policy makers worldwide in their decisions to introduce or modify vision and hearing screening programmes, and increase effectiveness, efficiency and equity of child healthcar

    Black Sickle Cell Patients’ Lives Matter: Healthcare, long- term shielding and psychological distress during a racialized pandemic in England – a mixed-methods study

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    Open accessObjective: To understand the psychological and social impact of shielding on people with sickle cell disorders and their carers in the Midlands region of England. This region was badly affected during the pandemic, with the city of Birmingham having some of the highest rates of COVID-19 deaths. Design: A mixed methods project with a quantitative survey on shielding and adapted SF36 v 2 questionnaire which was supplemented by qualitative semi-structured interviews analysed using Interpretive Phenomenological analysis (IPA). Participants: Fifty-one participants who were predominantly of Black Caribbean or Black African heritage anonymously took part in the online survey. We supplemented this with eight in-depth semi-structured interviews with adults with sickle cell disorders using IPA. Results: The adapted SF36 v2 survey indicated worse quality of life and mental health. The open-ended questions from the adapted survey also identified shielding concerns about hospital care, pain management and knowledge of sickle cell by healthcare professionals. From the interviews it emerged that the racialized element of the pandemic caused significant psychological distress for a population group that had to regularly access hospitals. It was noted that psychological health needs both during a pandemic and outside of it were poorly understood and became invisible in services. The psychological impact of experiences of hospital care as well as growing up with an invisible chronic condition were important to understand psychologically
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