Demographic characteristic of the population.

<p>Data are expressed as means ± SD, log-transformed values were used for statistical analysis.</p>*<p>P values were computed using ANOVA for continuous variables and Pearson’s Chi-square test for categorical values.</p><p>CAD: coronary artery disease; SA: subclinical atherosclerosis.</p

MOESM1 of Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus

Additional file 1: Table S1. Combined association of fatty liver and markers of adipose tissue dysfunction with the risk of IFG and nT2D in the paired-matched subpopulation

Association of the (C > T) rs1412444 polymorphism with coronary risk factors.

<p>All association were tested using logistic regression adjusted for age, gender, BMI, and medication when appropriate. (n) Represents the number of cases with each trait.</p><p>RAF: risk allele frequency.</p

Association of the (C > T) rs2246833 polymorphism with coronary risk factors.

<p>All association were tested using logistic regression adjusted for age, gender, BMI, and medication when appropriate. (n) Represents the number of cases with each trait.</p><p>RAF: risk allele frequency.</p

Comparison of biochemical parameters in individuals with premature coronary artery disease, subclinical atherosclerosis, and controls.

<p>Data are expressed as means ± SD, log-transformed values were used for statistical analysis.</p>*<p>P values were computed using ANOVA for continuous variables and Pearson’s Chi-square test for categorical values.</p><p>CAD: coronary artery disease; SA: subclinical atherosclerosis.</p

The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population

<div><p>Abstract We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.</p></div

Single Nucleotide Polymorphisms of the Angiotensin-Converting Enzyme (<i>ACE)</i> Gene Are Associated with Essential Hypertension and Increased ACE Enzyme Levels in Mexican Individuals

<div><p>Aim</p><p>To explore the role of the <i>ACE</i> gene polymorphisms in the risk of essential hypertension in Mexican Mestizo individuals and evaluate the correlation between these polymorphisms and the serum ACE levels.</p><p>Methods</p><p>Nine <i>ACE</i> gene polymorphisms were genotyped by 5′ exonuclease TaqMan genotyping assays and polymerase chain reaction (PCR) in 239 hypertensive and 371 non- hypertensive Mexican individuals. Haplotypes were constructed after linkage disequilibrium analysis. <i>ACE</i> serum levels were determined in selected individuals according to different haplotypes.</p><p>Results</p><p>Under a dominant model, rs4291 rs4335, rs4344, rs4353, rs4362, and rs4363 polymorphisms were associated with an increased risk of hypertension after adjusting for age, gender, BMI, triglycerides, alcohol consumption, and smoking. Five polymorphisms (rs4335, rs4344, rs4353, rs4362 and rs4363) were in strong linkage disequilibrium and were included in four haplotypes: H1 (<i>AAGCA</i>), H2 (<i>GGATG</i>), H3 (<i>AGATG</i>), and H4 (<i>AGACA</i>). Haplotype H1 was associated with decreased risk of hypertension, while haplotype H2 was associated with an increased risk of hypertension (OR = 0.77, <i>P</i> = 0.023 and OR = 1.41, <i>P</i> = 0.004 respectively). According to the codominant model, the H2/H2 and H1/H2 haplotype combinations were significantly associated with risk of hypertension after adjusted by age, gender, BMI, triglycerides, alcohol consumption, and smoking (OR = 2.0; <i>P</i> = 0.002 and OR = 2.09; <i>P</i> = 0.011, respectively). Significant elevations in serum ACE concentrations were found in individuals with the H2 haplotype (H2/H2 and H2/H1) as compared to H1/H1 individuals (<i>P</i> = 0.0048).</p><p>Conclusion</p><p>The results suggest that single nucleotide polymorphisms and the “<i>GGATG</i>” haplotype of the <i>ACE</i> gene are associated with the development of hypertension and with increased ACE enzyme levels.</p></div

Comparison of biochemical parameters in individuals with premature coronary artery disease and controls.

<p>Comparison of biochemical parameters in individuals with premature coronary artery disease and controls.</p

Comparison of biochemical parameters in individuals with premature CAD and healthy controls.

<p>Comparison of biochemical parameters in individuals with premature CAD and healthy controls.</p

Associations of <i>IL33</i> polymorphisms in patients with premature CAD and diabetes mellitus.

<p>Associations of <i>IL33</i> polymorphisms in patients with premature CAD and diabetes mellitus.</p