The Importance of the Entrepreneur’s Perception of “Success”

Purpose - In spite of the fact that the success of new ventures has been a widely studied topic in the field of entrepreneurship, no consensus on what is understood by the success of a firm can be found in the literature. Thus, the objective of this work is to discover what the entrepreneur really understands by the success of his/her business in its early years. To that end, this study clarifies the principal indicators used by entrepreneurs and analyses the relationship between how entrepreneurs understand the success of their business and the performance of that business. Design/methodology/approach – In a logit regression model, the research data are analyzed, using a sample of 98 entrepreneurs who are the heads of new firms in various sectors of activity. Findings - The study shows that there is a relationship between the way in which the entrepreneur measures how the business is doing and the performance of that business. More specifically, this research reveals that it is not the use of a greater number of indicators to measure the success that identifies the successful newly-created business from the unsuccessful, but the fact that those indicators are from different perspectives. Moreover, the results show that customer-related indicators are more effective than financial indicators to distinguish between successful and unsuccessful organizations. Research limitations/implications – Future research including qualitative interviews will help to further investigate the relationship between the entrepreneur’s perception of success and company performance. Practical implications – As a result of this research, the entrepreneurs can be conscience about how important it is the way they understand “the success” before they constitute their business. The results of this study mean a valuable knowledge to the academics that research in the entrepreneurship field, specifically to those that are focused on the success factors study. Originality/value – This research is pioneering in relating the way that the entrepreneur measures his company’s success and demonstrating its importance.Entrepreneur’s perception of success; new ventures; entrepreneurship.

The importance of prognosis in geriatric patients attending the emergency department: a comparison between two common short geriatric assessment tools

Background: The use of short geriatric tools in the emergency department (ED) is increasing, but the literature is still conflicting. The aim of this study is to compare the precision and the accuracy of two short geriatric assessment tools to predict mortality in a cohort of older patients attending the ED. Methods: A retrospective study was conducted including patients ≥ 65 years, attending the ED and transferred to a medical assessment unit from February to July 2022. Clinical Frailty Scale (CFS) and Brief Multidimensional Prognostic Index (Brief MPI) were administered. The association between Brief MPI and CFS and mortality was analysed via area under the curve (AUC) with its 95% confidence intervals (CIs), the C-statistics and a multivariate Cox’s regression analysis, in the latter case reporting the data as hazard ratios (HRs) with their 95% CI. Results: Among the 579 patients enrolled (mean age: 77 years), both Brief MPI and CFS showed a good accuracy in predicting mortality (AUC: 0.72; 95% CI: 0.61–0.83 for Brief MPI; 0.754; 95% CI: 0.65–0.83 for CFS). The discrimination of Brief MPI and CFS in predicting mortality was excellent, since the C-index of the Brief MPI was 0.85 and of CFS = 0.84. In the multivariate analysis, the risk for mortality was significantly increased for frailer subjects (HR 4.65; 95% CI: 1.45–15.00 for Brief MPI > 0.66; HR = 9.24; 95% CI: 1.16–76.90 for CFS > 6). Conclusions: Brief MPI and CFS showed a good accuracy/precision to predict mortality in older patients attending the ED. Considering that they are quick to perform, their introduction in ED clinical practice could be extremely helpful

The Cultural Practices that Influence on the Entrepreneurial Activity: An Empirical Study from the Globe Project Cultural Dimensions

There are few empirical studies focused on the culture, as one of the informal factors that influences business development in a region. The main purpose of this study is to analyze the perception of a society about its cultural practices based on cultural dimensions that are related to entrepreneurial activity. Through literature review, five cultural dimensions that would be closely related to entrepreneurship were identified, which has been corroborated in previous empirical studies. For this research, the city of Medellin (located in Colombia, developing country), which has been characterized by its high rate of business activity at the national level, is taken as context for the fieldwork. The findings show that the society under study perceives that its regional culture is characterized by a high level of assertiveness, hence its competitive nature and propensity to take risks, to boost the entrepreneurial activity.JEL Codes - M10; M13; M1

Palbociclib in a patient with HR+/HER2- advanced breast cancer and HIV1 infection: A case report

The use of drugs that affect the cell cycle represents one of the common strategies for the control of some unrelated pathologies, such as chronic viral HIV infections or cancer. The authors report the case of a patient followed for a hormone receptor-positive (HR+)/HER2 negative (HER2-) advanced breast cancer, treated with hormone therapy and CDK 4/6 inhibitors, and a concomitant HIV infection under antiretroviral treatment. The authors consider the function of the sterile alpha motif and HD domain-containing protein-1 (SAMHD1) enzyme, its implications in the control of viral replication and the correlation between its activity and the mechanism of action of the CDK 4/6 inhibitor palbociclib

Polymorphonuclear leukocyte integrins in deep venous thrombosis

The polymorphonuclear leukocytes (PMN) have a role in the pathophysiology of deep venous thrombosis (DVT). We examined the phenotypical expression of PMN beta(2M)-integrins (CD ll a, CDll b, CD 11c) in a group of 19 subjects with leg DVT. PMN cells were incubated with fluorescent monoclonal antibodies against CD11a, CD11b, CD11c, and the evaluation was made by flow cytofluorimetry. The same integrins were determined after in vitro activation with 4-phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP). In DVT subjects, at baseline, the phenotypical expression of CD11b was decreased and that of CD11c increased when compared with normal controls. In normal subjects PMN activation with PMA and fMLP led to a constant increase of all PMN adhesion molecules, while in DVT subjects the CDl l a did not show any change. These data might have therapeutical applications, especially with the aim of preventing post-thrombotic deterioration of vein function

No Brain No Game? Altered Sensorimotor and Fronto-Limbic Circuitry in Individuals with ACL Rupture

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Leukocyte Rheology Before and After Chemotactic Activation in some Venous Diseases

AbstractObjective: to evaluate leukocyte rheology, polymorphonuclear leukocyte (PMN) membrane fluidity and cytosolic Ca2+ concentration in subjects with post-phlebitic leg syndrome (PPS) and acute deep-venous leg thrombosis (DVT). Subjects: twenty-two subjects with leg PPS and 14 subjects with leg DVT. Methods: we evaluated the leukocyte filtration (unfractionated, mononuclear cells (MN) and PMN), the PMN membrane fluidity and the PMN cytosolic Ca2+ concentration. Subsequently, we evaluated the same PMN variables after in vitro chemotactic activation with 4-phorbol 12-myristate 13-acetate (PMA) and N -formyl-methionyl-leucyl-phenylalanine (fMLP). Results: at baseline we observed a significant difference in the filtration variables of unfractionated and MN cells and in PMN cytosolic Ca2+ concentration. After activation, in normal subjects and subjects with PPS and DVT, a significant variation in PMN filtration at 5 and 15 minutes was evident. In normal subjects, no variation was present in PMN membrane fluidity or cytosolic Ca2+ concentration after activation. In subjects with PPS and DVT, we found a decrease in PMN membrane fluidity and an increase in PMN cytosolic Ca2+ concentration. After PMN activation (at 5 and 15 min) Δ% of IRFR distinguished normal subjects from subjects with PPS and DVT, while no difference was found in Δ% of membrane fluidity or cytosolic Ca2+ concentration. Conclusions: there is a functional alteration of leukocytes in these patients whose mechanisms are not yet clear