40 research outputs found
Crescere a Pinerolo: stili di vita, benessere e futuro dei ragazzi
Come vivono i ragazzi? Cosa fanno, cosa pensano, come si relazionano in famiglia e con gli amici? Come aiutarli a crescere bene? Lo studio «Crescere a Pinerolo» si rivolge a 800 ragazzi, dai 12 fino ai 20 anni, che ci raccontano la loro vita, i loro problemi e difficoltĂ , ma anche le loro potenzialitĂ . I risultati offrono un quadro positivo degli adolescenti: il dialogo con i genitori favorisce le relazioni in famiglia e complessivamente si sentono supportati e protetti, la scuola piace abbastanza e viene compresa lâimportanza dellâistruzione. Tra gli aspetti critici che emergono vi sono: la solitudine nellâera digitale, il bullismo verbale e relazionale, lâincertezza del futuro.Fil: Vignola Barbero, G.. Fondazione Emanuela Zancan; ItaliaFil: Canali, Cinzia. Fondazione Emanuela Zancan; ItaliaFil: Eynard, Martin. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de CĂłrdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; ArgentinaFil: Vecchiato, Tiziano. Fondazione Emanuela Zancan; Itali
International Perspectives on Parenting Support - Non-English Language Sources
This study was commissioned by the DCSF, and began in October 2007. The project aimed to extend existing knowledge of âwhat worksâ in parenting support beyond the English language international evidence that was comprehensively reviewed in an earlier study for DCSF (What Works in Parenting Support, Moran, Ghate and van der Merwe 2004).
While the previous study focused on English language literature, the focus of this study was to examine parenting support in a selection of non-English language countries.
Five countries were selected from an initial list of 12 (originally chosen from a longer list of 22). Their selection was based on the relevance to UK policy and practice, potential translatability to a UK context and indications of promising practice
The SMAD pathway is required for hepcidin response during endoplasmic reticulum stress
Hepcidin, the iron hormone, is regulated by a number of stimulatory and inhibitory signals. The cAMP responsive element binding protein 3-like 3, CREB3L3, mediates hepcidin response to endoplasmic reticulum (ER) stress. In this study we asked whether hepcidin response to ER stress also requires the SMAD1/5/8 pathway that has a major role in hepcidin regulation in response to iron and other stimuli. We analyzed hepcidin mRNA expression and promoter activity in response to ER stressors in HepG2 cells in the presence of the BMP type I receptor inhibitor LDN-193189, mutated hepcidin promoter or siRNA against different SMAD proteins. We then used a similar approach in vivo in wild-type, Smad1/5 or Creb3l3 -/- animals undergoing ER stress. In vitro, LDN-193189 prevented hepcidin mRNA induction by different ER stressors. Seemingly, mutation of a BMP-responsive element in the hepcidin promoter prevented ER stress-mediated upregulation. Moreover, in vitro silencing of SMAD proteins by siRNA, in particular SMAD5, blunted hepcidin response to ER stress. On the contrary, hepcidin induction by ER stress was maintained when using antibodies against canonical BMP receptor ligands. In vivo, hepcidin was induced by ER stress and prevented by LDN-193189. In addition, in Smad1/5 knock-out mice, ER stress was unable to induce hepcidin expression. Finally, in Creb3l3 knock-out mice, in response to ER stress, SMAD1/5 were correctly phosphorylated and hepcidin induction was still appreciable, although to a lesser extent as compared to control mice. In conclusion, our study indicates that hepcidin induction by ER stress involves the central regulatory SMAD1/5 pathway
Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice.
Hepatic gluconeogenesis provides fuel during starvation, and is abnormally induced in obese individuals or those
with diabetes. Common metabolic disorders associated with active gluconeogenesis and insulin resistance (obesity,
metabolic syndrome, diabetes, and nonalcoholic fatty liver disease) have been associated with alterations in iron
homeostasis that disrupt insulin sensitivity and promote disease progression. We investigated whether gluconeogenic
signals directly control Hepcidin, an important regulator of iron homeostasis, in starving mice (a model of persistently
activated gluconeogenesis and insulin resistance).|We investigated hepatic regulation of Hepcidin expression in
C57BL/6Crl, 129S2/SvPas, BALB/c, and wild-type and Creb3l3-/- null mice. Mice were fed a standard, iron-balanced
chow diet or an iron-deficient diet for 9 days before death, or for 7 days before a 24- to 48-hour starvation period;
liver and spleen tissues then were collected and analyzed by quantitative reverse-transcription polymerase chain
reaction and immunoblot analyses. Serum levels of iron, hemoglobin, Hepcidin, and glucose also were measured. We
analyzed human hepatoma (HepG2) cells and mouse primary hepatocytes to study transcriptional control of Hamp
(the gene that encodes Hepcidin) in response to gluconeogenic stimuli using small interfering RNA, luciferase
promoter, and chromatin immunoprecipitation analyses.|Starvation led to increased transcription of encodes
phosphoenolpyruvate carboxykinase 1 (a protein involved in gluconeogenesis) in livers of mice, increased levels of
Hepcidin, and degradation of Ferroportin, compared with nonstarved mice. These changes resulted in hypoferremia
and iron retention in liver tissue. Livers of starved mice also had increased levels of Ppargc1a messenger RNA and
Creb3l3 messenger RNA, which encode a transcriptional co-activator involved in energy metabolism and a liverspecific
transcription factor, respectively. Glucagon and a cyclic adenosine monophosphate analog increased promoter
activity and transcription of Hamp in cultured liver cells; levels of Hamp were reduced after administration of small
interfering RNAs against Ppargc1a and Creb3l3. PPARGC1A and CREB3L3 bound the Hamp promoter to activate its
transcription in response to a cyclic adenosine monophosphate analog. Creb3l3-/- mice did not up-regulate Hamp or
become hypoferremic during starvation.|We identified a link between glucose and iron homeostasis, showing that
Hepcidin is a gluconeogenic sensor in mice during starvation. This response is involved in hepatic metabolic adaptation
to increased energy demands; it preserves tissue iron for vital activities during food withdrawal, but can cause
excessive iron retention and hypoferremia in disorders with persistently activated gluconeogenesis and insulin
resistance
Therapeutic residential care for children and youth:A consensus statement of the International Work Group on Therapeutic Residential Care
Therapeutic Residential Care for Children and Youth: A Consensus Statement of the International Work Group on Therapeutic Residential Care
Therapeutic Residential Care for Children and Youth: A Consensus Statement of the International Work Group on Therapeutic Residential Care
Therapeutische residentiële hulp voor kinderen en jongeren : een consensusverklaring van de Internationale Werkgroep Therapeutische Residentiële Zorg
In many developed countries around the world residential care interventions for children and adolescents have come under increasing scrutiny. Against this background an international summit was organised in England (spring 2016) with experts from 13 countries to reflect on therapeutic residential care (TRC). The following working definition of TRC was leading: "Therapeutic residential care involves the planful use of a purposefully constructed, multi-dimensional living environment designed to enhance or provide treatment, education, socialization, support, and protection to children and youth with identified mental health or behavioural needs in partnership with their families and in collaboration with a full spectrum of community based formal and informal helping resources". The meeting was characterised by exchange of information and evidence, and by preparing an international research agenda. In addition, the outlines of a consensus statement on TRC were discussed. This statement, originally published in English and now reproduced in a Dutch translation, comprises inter alia five basic principles of care that according to the Work Group on Therapeutic Residential Care should be guiding for residential youth care provided at any time