120 research outputs found
EPOBF: Energy Efficient Allocation of Virtual Machines in High Performance Computing Cloud
Cloud computing has become more popular in provision of computing resources
under virtual machine (VM) abstraction for high performance computing (HPC)
users to run their applications. A HPC cloud is such cloud computing
environment. One of challenges of energy efficient resource allocation for VMs
in HPC cloud is tradeoff between minimizing total energy consumption of
physical machines (PMs) and satisfying Quality of Service (e.g. performance).
On one hand, cloud providers want to maximize their profit by reducing the
power cost (e.g. using the smallest number of running PMs). On the other hand,
cloud customers (users) want highest performance for their applications. In
this paper, we focus on the scenario that scheduler does not know global
information about user jobs and user applications in the future. Users will
request shortterm resources at fixed start times and non interrupted durations.
We then propose a new allocation heuristic (named Energy-aware and Performance
per watt oriented Bestfit (EPOBF)) that uses metric of performance per watt to
choose which most energy-efficient PM for mapping each VM (e.g. maximum of MIPS
per Watt). Using information from Feitelson's Parallel Workload Archive to
model HPC jobs, we compare the proposed EPOBF to state of the art heuristics on
heterogeneous PMs (each PM has multicore CPU). Simulations show that the EPOBF
can reduce significant total energy consumption in comparison with state of the
art allocation heuristics.Comment: 10 pages, in Procedings of International Conference on Advanced
Computing and Applications, Journal of Science and Technology, Vietnamese
Academy of Science and Technology, ISSN 0866-708X, Vol. 51, No. 4B, 201
Biological activity of antitumoural MGBG: the structural variable
Abstract The present study aims at determining the structure-activity relationships (SAR’s) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG’s structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations
Structural characterization of agmatine at physiological conditions
Abstract The present work aims at determining the structure-activity relationships (SAR's) which rule the biological function of agmatine (4-(aminobutyl)guanidinium, AGM), a biogenic amine produced by decarboxylation of arginine. Its structural preferences, both as an isolated molecule and in aqueous solution (namely at physiological conditions) were ascertained, by vibrational (Raman) spectroscopy coupled to theoretical (density functional) calculations. An evaluation of mitochondrial functions (membrane potential ( ), mitochondrial swelling, and cytochrome c release) in rat liver mitochondria (RLM) was also carried out. The results thus obtained, coupled to the conformational analysis performed for the distinct polyamine protonation states, allowed to individualize the agmatine structures which interact with the mitochondrial site responsible for its transport and for the protection against mitochondrial permeability transition (MPT) induction, a
Growth and yield of sugarcane as a function of phosphorus doses and forms of application
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