Secondary Flow Control in Low Aspect Ratio Vanes Using Splitters

Low aspect ratio vanes, often the result of overall engine architecture constraints, create strong secondary flows and high end-wall loss. In this paper, a splitter concept is demonstrated that reduces secondary flow strength and improves stage performance. An analytic conceptual study, corroborated by inviscid computations, shows that the total secondary kinetic energy (SKE) of the secondary flow vortices is reduced when the number of passages is increased and, for a given number of vanes, when the inlet end-wall boundary layer is evenly distributed between the passages. Viscous computations show that, for this to be achieved in a splitter configuration, the pressure-side leg of the low aspect ratio vane horseshoe vortex, must enter the adjacent passage (and not “jump” in front of the splitter leading edge). For a target turbine application, four vane designs were produced using a multi-objective optimization approach. These designs represent current practice for a low aspect ratio vane, a design exempt from thickness constraints, and two designs incorporating splitter vanes. Each geometry is tested experimentally, as a sector, within a low-speed turbine stage. The vane designs with splitter geometries were found to reduce the measured secondary kinetic energy, by up to 85%, to a value similar to the design exempt from thickness constraints. The resulting flow field was also more uniform in both the circumferential and radial directions. One splitter design was selected for a full annulus test where a mixed-out loss reduction, compared to the current practice design, of 15.3% was measured and the stage efficiency increased by 0.88%.The work was funded by Rolls-Royce plc under the SILOET 2 work package

Student Research Projects With Industrial Impact

Abstract This paper describes six final year undergraduate research projects supported by a collaboration between the Whittle Laboratory at the University of Cambridge and Reaction Engines (RE), a UK aerospace company. The collaboration is now in its fourth year of projects relating to RE's synergetic air breathing rocket engine (SABRE). The approach taken in these projects combines modern teaching pedagogy with a best practice methodology for industrial-academic collaboration and a well established framework for structuring research problems. This paper explains how the three methodologies are tailored and adapted for use with final year undergraduate research projects. The approach is mapped on to an annual project cycle which begins with the industry and academic partners deciding which topics to investigate and proceeds through student selection, the project work itself and concludes with student assessment and end-of-year reporting. The projects combine analytical, computational and experimental work and have covered counter-rotating turbomachinery, S-ducts in compressors and Helium Turbine design, all of which are topics of primary importance to the design of SABRE. Following descriptions of each of the six completed projects, the impact of the work and lessons learned are considered from the point of view of the students, the industrial partner and the academic supervisors. Overall, the students found the work extremely engaging and have all been encouraged to pursue careers in engineering, either in industry or through postgraduate study. For the industry partner the collaboration provides expertise and an approach which is not available in-house as well providing a “second look” at key technical questions. For the academics involved, the opportunity to lead research on a “real” problem with an industrial partner has proved highly motivating as well as providing opportunities for personal and career development.The student projects were funded by Reaction Engine

Temporal Variant Frontotemporal Dementia Is Associated with Globular Glial Tauopathy

Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous neurodegenerative disorder associated with atrophy of the frontal and temporal lobes. Most patients with focal temporal lobe atrophy present with either the semantic dementia subtype of FTD or the behavioral variant subtype. For patients with temporal variant FTD, the most common cause found on post-mortem examination has been a TDP-43 (transactive response DNA-binding protein 43 kDa) proteinopathy, but tauopathies have also been described, including Pick’s disease and mutations in the microtubule-associated protein tau (MAPT) gene. We report the clinical and imaging features of 2 patients with temporal variant FTD associated with a rare frontotemporal lobar degeneration pathology known as globular glial tauopathy. The pathologic diagnosis of globular glial tauopathy should be considered in patients with temporal variant FTD, particularly those who have atypical semantic dementia or an atypical parkinsonian syndrome in association with the right temporal variant

Two cases of food aversion with semantic dementia

Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences. Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome. One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa. These cases add to the growing spectrum of apparently dichotomous behavior patterns in the frontotemporal dementias and illustrate a potentially under-recognized cause of eating disorders presenting in later life

A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland.

BACKGROUND: This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbouring one to two copies of a transgene comprised of the ovine beta-lactoglobulin milk protein gene promoter, driving expression of a temperature-sensitive variant of simian virus-40 (SV40) large T antigen (T-Ag). RESULTS: KIM-2 cells have a characteristic luminal epithelial cell morphology and a stable, nontransformed phenotype at the semipermissive temperature of 37 degrees C. In contrast, at the permissive temperature of 33 degrees C the cells have an elongated spindle-like morphology and become transformed after prolonged culture. Differentiation of KIM-2 cells at 37 degrees C, in response to lactogenic hormones, results in the formation of polarized dome-like structures with tight junctions. This is accompanied by expression of the milk protein genes that encode beta-casein and whey acidic protein (WAP), and activation of the prolactin signalling molecule, signal transducer and activator of transcription (STAT)5. Fully differentiated KIM-2 cultures at 37 degrees C become dependent on lactogenic hormones for survival and undergo extensive apoptosis upon hormone withdrawal, as indicated by nuclear morphology and flow cytometric analysis. KIM-2 cells can be genetically modified by stable transfection and clonal lines isolated that retain the characteristics of untransfected cells. CONCLUSION: KIM-2 cells are a valuable addition, therefore, to currently available lines of mammary epithelial cells. Their capacity for extensive differentiation in the absence of exogenously added basement membrane, and ability to undergo apoptosis in response to physiological signals will provide an invaluable model system for the study of signal transduction pathways and transcriptional regulatory mechanisms that control differentiation and involution in the mammary gland

At Least Bias Is Bipartisan: A Meta-Analytic Comparison of Partisan Bias in Liberals and Conservatives

Both liberals and conservatives accuse their political opponents of partisan bias, but is there empirical evidence that one side of the political aisle is indeed more biased than the other? To address this question, we meta-analyzed the results of 51 experimental studies, involving over 18,000 participants, that examined one form of partisan bias—the tendency to evaluate otherwise identical information more favorably when it supports one’s political beliefs or allegiances than when it challenges those beliefs or allegiances. Two hypotheses based on previous literature were tested: an asymmetry hypothesis (predicting greater partisan bias in conservatives than in liberals) and a symmetry hypothesis (predicting equal levels of partisan bias in liberals and conservatives). Mean overall partisan bias was robust (r = .245), and there was strong support for the symmetry hypothesis: Liberals (r = .235) and conservatives (r = .255) showed no difference in mean levels of bias across studies. Moderator analyses reveal this pattern to be consistent across a number of different methodological variations and political topics. Implications of the current findings for the ongoing ideological symmetry debate and the role of partisan bias in scientific discourse and political conflict are discussed

Exploring the measurement of markedness and its relationship with other linguistic variables

Antonym pair members can be differentiated by each word's markedness-that distinction attributable to the presence or absence of features at morphological or semantic levels. Morphologically marked words incorporate their unmarked counterpart with additional morphs (e.g., "unlucky" vs. "lucky"); properties used to determine semantically marked words (e.g., "short" vs. "long") are less clearly defined. Despite extensive theoretical scrutiny, the lexical properties of markedness have received scant empirical study. The current paper employs an antonym sequencing approach to measure markedness: establishing markedness probabilities for individual words and evaluating their relationship with other lexical properties (e.g., length, frequency, valence). Regression analyses reveal that markedness probability is, as predicted, related to affixation and also strongly related to valence. Our results support the suggestion that antonym sequence is reflected in discourse, and further analysis demonstrates that markedness probabilities, derived from the antonym sequencing task, reflect the ordering of antonyms within natural language. In line with the Pollyanna Hypothesis, we argue that markedness is closely related to valence; language users demonstrate a tendency to present words evaluated positively ahead of those evaluated negatively if given the choice. Future research should consider the relationship of markedness and valence, and the influence of contextual information in determining which member of an antonym pair is marked or unmarked within discourse

An Unsteady Pressure Probe for the Measurement of Flow Unsteadiness in Tidal Channels

IEEE An unsteady five-hole probe has been developed for the measurement of turbulent flow in tidal channels. Such measurements are vital for accurate prediction of unsteady loads on tidal turbines. Existing field-based velocimeters are either unable to capture the required range of frequencies or are too expensive to profile the variation of turbulence across a typical tidal power site, and thus the available data is inadequate for turbine design. This work adapts the traditional five-hole wind tunnel probe to achieve a low-cost device with sufficient frequency range for tidal turbine applications. The main issue in the marine environment is that the ambient hydrostatic pressure is much higher than the dynamic pressure. This has been overcome by using novel calibration coefficients and differential transducers. In flume tank tests against laser Doppler velocimeter measurements, the frequency response of the probe has been shown to be sufficient to capture all the frequencies necessary for tidal turbine design