2,181 research outputs found
Exploring Replica-Exchange Wang-Landau sampling in higher-dimensional parameter space
We considered a higher-dimensional extension for the replica-exchange
Wang-Landau algorithm to perform a random walk in the energy and magnetization
space of the two-dimensional Ising model. This hybrid scheme combines the
advantages of Wang-Landau and Replica-Exchange algorithms, and the
one-dimensional version of this approach has been shown to be very efficient
and to scale well, up to several thousands of computing cores. This approach
allows us to split the parameter space of the system to be simulated into
several pieces and still perform a random walk over the entire parameter range,
ensuring the ergodicity of the simulation. Previous work, in which a similar
scheme of parallel simulation was implemented without using replica exchange
and with a different way to combine the result from the pieces, led to
discontinuities in the final density of states over the entire range of
parameters. From our simulations, it appears that the replica-exchange
Wang-Landau algorithm is able to overcome this difficulty, allowing exploration
of higher parameter phase space by keeping track of the joint density of
states.Comment: Proceedings of CCP2014 will appear in Journal of Physics: Conference
Series (JPCS), published by the IO
Resolving spin, valley, and moir\'e quasi-angular momentum of interlayer excitons in WSe2/WS2 heterostructures
Moir\'e superlattices provide a powerful way to engineer properties of
electrons and excitons in two-dimensional van der Waals heterostructures. The
moir\'e effect can be especially strong for interlayer excitons, where
electrons and holes reside in different layers and can be addressed separately.
In particular, it was recently proposed that the moir\'e superlattice potential
not only localizes interlayer exciton states at different superlattice
positions, but also hosts an emerging moir\'e quasi-angular momentum (QAM) that
periodically switches the optical selection rules for interlayer excitons at
different moir\'e sites. Here we report the observation of multiple interlayer
exciton states coexisting in a WSe2/WS2 moir\'e superlattice and unambiguously
determine their spin, valley, and moir\'e QAM through novel resonant optical
pump-probe spectroscopy and photoluminescence excitation spectroscopy. We
demonstrate that interlayer excitons localized at different moir\'e sites can
exhibit opposite optical selection rules due to the spatially-varying moir\'e
QAM. Our observation reveals new opportunities to engineer interlayer exciton
states and valley physics with moir\'e superlattices for optoelectronic and
valleytronic applications
Superconductivity suppression of Ba0.5K0.5Fe2-2xM2xAs2 single crystals by substitution of transition-metal (M = Mn, Ru, Co, Ni, Cu, and Zn)
We investigated the doping effects of magnetic and nonmagnetic impurities on
the single-crystalline p-type Ba0.5K0.5Fe2-2xM2xAs2 (M = Mn, Ru, Co, Ni, Cu and
Zn) superconductors. The superconductivity indicates robustly against impurity
of Ru, while weakly against the impurities of Mn, Co, Ni, Cu, and Zn. However,
the present Tc suppression rate of both magnetic and nonmagnetic impurities
remains much lower than what was expected for the s\pm-wave model. The
temperature dependence of resistivity data is observed an obvious low-T upturn
for the crystals doped with high-level impurity, which is due to the occurrence
of localization. Thus, the relatively weak Tc suppression effect from Mn, Co,
Ni, Cu, and Zn are considered as a result of localization rather than
pair-breaking effect in s\pm-wave model.Comment: 8 pages, 9 figures, to be published in Phys. Rev.
Predictors of functional deterioration in Chinese patients with Psoriatic arthritis: A longitudinal study.
10.1186/1471-2474-15-284BMC Musculoskeletal Disorders15128
Integrated microfluidic systems with sample preparation and nucleic acid amplification
Rapid, efficient and accurate nucleic acid molecule detection is important in the screening of diseases and pathogens, yet remains a limiting factor at point of care (POC) treatment. Microfluidic systems are characterized by fast, integrated, miniaturized features which provide an effective platform for qualitative and quantitative detection of nucleic acid molecules. The nucleic acid detection process mainly includes sample preparation and target molecule amplification. Given the advancements in theoretical research and technological innovations to date, nucleic acid extraction and amplification integrated with microfluidic systems has advanced rapidly. The primary goal of this review is to outline current approaches used for nucleic acid detection in the context of microfluidic systems. The secondary goal is to identify new approaches that will help shape future trends at the intersection of nucleic acid detection and microfluidics, particularly with regard to increasing disease and pathogen detection for improved diagnosis and treatment
Remote generation of entanglement for individual atoms via optical fibers
The generation of atomic entanglement is discussed in a system that atoms are
trapped in separate cavities which are connected via optical fibers. Two
distant atoms can be projected to Bell-state by synchronized turning off the
local laser fields and then performing a single quantum measurement by a
distant controller. The distinct advantage of this scheme is that it works in a
regime that , which makes the scheme insensitive to
cavity strong leakage. Moreover, the fidelity is not affected by atomic
spontaneous emission.Comment: 4 pages, 3 figure
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Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma
Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry will be required for meaningful clinical efficacy. We conducted parallel genome-wide shRNA screens to identify such nodes and uncovered a number of G-Protein Coupled Receptor (GPCR) neurotransmitter pathways, including the Dopamine Receptor D2 (DRD2) signaling pathway. Supporting the importance of DRD2 in glioblastoma, DRD2 mRNA and protein expression were elevated in clinical glioblastoma specimens relative to matched non-neoplastic cerebrum. Treatment with independent si-/shRNAs against DRD2 or with DRD2 antagonists suppressed the growth of patient-derived glioblastoma lines both in vitro and in vivo. Importantly, glioblastoma lines derived from independent genetically engineered mouse models (GEMMs) were more sensitive to haloperidol, an FDA approved DRD2 antagonist, than the premalignant astrocyte lines by approximately an order of magnitude. The pro-proliferative effect of DRD2 was, in part, mediated through a GNAI2/Rap1/Ras/ERK signaling axis. Combined inhibition of DRD2 and Epidermal Growth Factor Receptor (EGFR) led to synergistic tumoricidal activity as well as ERK suppression in independent in vivo and in vitro glioblastoma models. Our results suggest combined EGFR and DRD2 inhibition as a promising strategy for glioblastoma treatment
A Deep Prediction Network for Understanding Advertiser Intent and Satisfaction
For e-commerce platforms such as Taobao and Amazon, advertisers play an
important role in the entire digital ecosystem: their behaviors explicitly
influence users' browsing and shopping experience; more importantly,
advertiser's expenditure on advertising constitutes a primary source of
platform revenue. Therefore, providing better services for advertisers is
essential for the long-term prosperity for e-commerce platforms. To achieve
this goal, the ad platform needs to have an in-depth understanding of
advertisers in terms of both their marketing intents and satisfaction over the
advertising performance, based on which further optimization could be carried
out to service the advertisers in the correct direction. In this paper, we
propose a novel Deep Satisfaction Prediction Network (DSPN), which models
advertiser intent and satisfaction simultaneously. It employs a two-stage
network structure where advertiser intent vector and satisfaction are jointly
learned by considering the features of advertiser's action information and
advertising performance indicators. Experiments on an Alibaba advertisement
dataset and online evaluations show that our proposed DSPN outperforms
state-of-the-art baselines and has stable performance in terms of AUC in the
online environment. Further analyses show that DSPN not only predicts
advertisers' satisfaction accurately but also learns an explainable advertiser
intent, revealing the opportunities to optimize the advertising performance
further
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