Novel Cellular Therapies for Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Most patients present with advanced disease, and current gold-standard management using tyrosine kinase inhibitors or immune checkpoint inhibitors (ICIs) offers modest clinical benefit. Cellular immune therapies targeting HCC are currently being tested in the laboratory and in clinical trials. Here, we review the landscape of cellular immunotherapy for HCC, defining antigenic targets, outlining the range of cell therapy products being applied in HCC (such as CAR-T and TCR-T), and exploring how advanced engineering solutions may further enhance this therapeutic approach

Gowin's Knowledge Vee and the integration of philosophy and methodology : a case study

Universities with a strong research tradition commonly have courses or modules examining the tradition’s philosophies and methodologies to prepare their students to undertake research programmes. Recently, however, authors have called for wider debate concerning how we teach these courses and this paper is intended, in part, to make a contribution to this debate. The Research Philosophy and Methodology module examined here makes an intriguing case study because of a number of distinctive characteristics. The teaching philosophy of the module is social constructivist and it uses Gowin’s Knowledge Vee as its main heuristic device. This facilitates the construction of knowledge about philosophy and methodology in an integrated manner. The module has also been designed for both physical and human geography students at the introductory post-graduate level. There is, therefore, a second element of integration in the curriculum. Lastly, the module is predominantly web-based, being taken by distance students through the exchange agreement between Rhodes University, South Africa, and the University of Trollhättan-Uddevalla, Sweden. Evidence from reflective exercises shows that the learners’ understanding of research and the research process has deepened considerably through using Gowin’s Vee. Furthermore, using the Knowledge Vee in the web-based context has facilitated the integrative aspects of the module

Successful MRI-Guided Focused Ultrasound Uterine Fibroid Treatment Despite an Ostomy and Significant Abdominal Wall Scarring

We present a case of successful magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) of a uterine fibroid in a patient with extensive anterior abdominal wall surgical scars from two longitudinal laparotomies, a total colectomy and ileostomy. This case demonstrates that MRgFUS can be safely used in patients with an ostomy and significant abdominal wall scarring, but careful pretreatment planning and positioning during treatment is needed

Mecanismos de transmisión de la política monetaria y el impacto de una devaluación en el nivel de las firmas

La presente investigación examina distintas evidencias sobre la existencia del canal de hoja de balance en el nivel de firmas en la economía peruana. Mediante el empleo de modelos de panel estáticos y dinámicos y una muestra de 2 054 empresas no financieras, con información anual para el intervalo entre 1997 y 2001, se valida el funcionamiento de dicho canal, con efectos asimétricos de la emisión primaria y la devaluación real a través del nivel de endeudamiento y su costo implícito.

2014 Bethsaida Field Report

The 2014 excavation season at Bethsaida took place during May 18th to July 5th. One hundred and twenty five faculty, students and volunteers took part in the expedition. The expedition was housed for four weeks at Kibbutz Hukok and two weeks at Kibbutz Ginosar. We are very grateful for the extraordinary hospitality that we have had in the two places

2013 Bethsaida Field Report

The 2013 excavation season at Bethsaida took place between May 21 and June 28. About 120 faculty, students and volunteers participated in the excavation. The expedition was housed for the first two weeks at Kibbutz Hukok and four weeks at Kibbutz Ginosar. We are very grateful for the extraordinary hospitality that we have had in the two places

Persistent Longitudinal Variations of Plasma Density and DC Electric Fields in the Low Latitude Ionosphere Observed with Probes on the C/NOFS Satellite

Continuous measurements using in situ probes on consecutive orbits of the C/N0FS satellite reveal that the plasma density is persistently organized by longitude, in both day and night conditions and at all locations within the satellite orbit, defined by its perigee and apogee of 401 km and 867 km, respectively, and its inclination of 13 degrees. Typical variations are a factor of 2 or 3 compared to mean values. Furthermore, simultaneous observations of DC electric fields and their associated E x B drifts in the low latitude ionosphere also reveal that their amplitudes are also strongly organized by longitude in a similar fashion. The drift variations with longitude are particularly pronounced in the meridional component perpendicular to the magnetic field although they are also present in the zonal component as well. The longitudes of the peak meridional drift and density values are significantly out of phase with respect to each other. Time constants for the plasma accumulation at higher altitudes with respect to the vertical drift velocity must be taken into account in order to properly interpret the detailed comparisons of the phase relationship of the plasma density and plasma velocity variations. Although for a given period corresponding to that of several days, typically one longitude region dominates the structuring of the plasma density and plasma drift data, there is also evidence for variations organized about multiple longitudes at the same time. Statistical averages will be shown that suggest a tidal "wave 4" structuring is present in both the plasma drift and plasma density data. We interpret the apparent association of the modulation of the E x B drifts with longitude as well as that of the ambient plasma density as a manifestation of tidal forces at work in the low latitude upper atmosphere. The observations demonstrate how the high duty cycle of the C/NOFS observations and its unique orbit expose fundamental processes at work in the low latitude, inner regions of geospace

2015 Bethsaida Field Report

The 2015 excavation season at Bethsaida took place during May 28th to July 3rd, 2015. Seventy six faculty, students and volunteers joined this season. The expedition was hosted in Ginosar Village, Kibbutz Ginosar. We are very grateful for the kind and efficient hospitality Ginosar team and members, provides us for more than 20 years

Identification and characterization of prodromal risk syndromes in young adolescents in the community: a population-based clinical interview study.

While a great deal of research has been conducted on prodromal risk syndromes in relation to help-seeking individuals who present to the clinic, there is a lack of research on prodromal risk syndromes in the general population. The current study aimed first to establish whether prodromal risk syndromes could be detected in non-help-seeking community-based adolescents and secondly to characterize this group in terms of Axis-1 psychopathology and general functioning. We conducted in-depth clinical interviews with a population sample of 212 school-going adolescents in order to assess for prodromal risk syndromes, Axis-1 psychopathology, and global (social/occupational) functioning. Between 0.9% and 8% of the community sample met criteria for a risk syndrome, depending on varying disability criteria. The risk syndrome group had a higher prevalence of co-occurring nonpsychotic Axis-1 psychiatric disorders (OR = 4.77, 95% CI = 1.81-12.52; P \u3c .01) and poorer global functioning (F = 24.5, df = 1, P \u3c .0001) compared with controls. Individuals in the community who fulfill criteria for prodromal risk syndromes demonstrate strong similarities with clinically presenting risk syndrome patients not just in terms of psychotic symptom criteria but also in terms of co-occurring psychopathology and global functioning