Microscopes and computers combined for analysis of chromosomes

Scanning machine CHLOE, developed for photographic use, is combined with a digital computer to obtain quantitative and statistically significant data on chromosome shapes, distribution, density, and pairing. CHLOE permits data acquisition about a chromosome complement to be obtained two times faster than by manual pairing

Regaining Motor Control in Musician's Dystonia by Restoring Sensorimotor Organization

Professional musicians are an excellent human model of long term effects of skilled motor training on the structure and function of the motor system. However, such effects are accompanied by an increased risk of developing motor abnormalities, in particular musician's dystonia. Previously we found that there was an expanded spatial integration of proprioceptive input into the hand area of motor cortex (sensorimotor organisation, SMO) in healthy musicians as tested with a transcranial magnetic stimulation (TMS) paradigm. In musician's dystonia, this expansion was even larger, resulting in a complete lack of somatotopic organisation. We hypothesised that the disordered motor control in musician's dystonia is a consequence of the disordered SMO. In the present paper we test this idea by giving pianists with musician's dystonia 15 min experience of a modified proprioceptive training task. This restored SMO towards that seen in healthy pianists. Crucially, motor control of the affected task improved significantly and objectively as measured with a MIDI piano, and the amount of behavioural improvement was significantly correlated to the degree of sensorimotor re-organisation. In healthy pianists and non-musicians, the SMO and motor performance remained essentially unchanged. These findings suggest a link between the differentiation of SMO in the hand motor cortex and the degree of motor control of intensively practiced tasks in highly skilled individuals

ScotPID - a model of collaboration

ScotPID is a national personal development initiative in Scotland, with thirteen higher education institutions taking part in the development of case studies which enhance personal development planning for students. As a model of collaboration, ScotPID involves all stakeholders: each core project group is composed of an academic, IT support manager, careers service adviser and undergraduate student, with support from QAA Scotland. The case study is developed by the contribution of all of the members of the team. The strength of the ScotPID collaboration is the varied background of the team members. However, collaboration between the ScotPID teams should also be encouraged, to strengthen the inter-institutional approach further

Basic studies of baroclinic flows

A fully nonlinear 3-dimensional numerical model (GEOSIM), previously developed and validated for several cases of geophysical fluid flow, has been used to investigate the dynamical behavior of laboratory experiments of fluid flows similar to those of the Earth's atmosphere. The phenomena investigated are amplitude vacillation, and the response of the fluid system to uneven heating and cooling. The previous year's work included hysteresis in the transition between axisymmetric and wave flow. Investigation is also continuing of the flows in the Geophysical Fluid Flow Cell (GFFC), a low-gravity Spacelab experiment. Much of the effort in the past year has been spent in validation of the model under a wide range of external parameters including nonlinear flow regimes. With the implementation of a 3-dimensional upwind differencing scheme, higher spectral resolution, and a shorter time step, the model has been found capable of predicting the majority of flow regimes observed in one complete series of baroclinic annulus experiments of Pfeffer and co-workers. Detailed analysis of amplitude vacillation has revealed that the phase splitting described in the laboratory experiments occurs in some but not all cases. Through the use of animation of the models output, a vivid 3-dimensional view of the phase splitting was shown to the audience of the Southeastern Geophysical Fluid Dynamics Conference in March of this year. A study on interannual variability was made using GEOSIM with periodic variations in the thermal forcing. Thus far, the model has not predicted a chaotic behavior as observed in the experiments, although there is a sensitivity in the wavenumber selection to the initial conditions. Work on this subject, and on annulus experiments with non-axisymmetric thermal heating, will continue. The comparison of GEOSIM's predictions will result from the Spacelab 3 GFFC experiments continued over the past year, on a 'back-burner' basis. At this point, the study (in the form of a draft of a journal article) is nearly completed. The results from GEOSIM compared very well with the experiments, and the use of the model allows the demonstration of flow mechanics that were not possible with the experimental data. For example, animation of the model output shows that the forking of the spiral bands is a transient phenomenon, due to the differential east-west propagation of convection bands from different latitudes

Indices for the identification of biologically productive cashmere goats within farms

Objectively comparing cashmere goats with different cashmere production, mean fibre diameter (MFD) and staple length (SL) is difficult for farmers. We aimed to develop indices to enable cashmere producers to identify productive goats within their own farms once adjustments had been made for the primary determinants of cashmere production. That is we aimed to develop indices that identify goats and herds that biologically have a high fleece weight in relation to MFD and SL. We used a sample of 1244 commercial cashmere fleeces from goats originating from many Australian farms based in different environmental zones and a previously developed general linear model that related the logarithm of clean cashmere production (CCMwt) and any other potential determinant. In the present study, sub-models were investigated in order to develop new indices for comparing goats in the same farm, based on fleece characteristics and biological efficiency. New Index (MFD), equal to 6.02×CCMwt/1.1531MFD, was developed to identify animals of biologically high CCMwt in relation to their MFD. Unlike previously reported results that MFD is not a useful measurement for comparing the biological efficiency of cashmere goats across farms, the New Index (MFD) allows comparison of the biological efficiency of cashmere goats within farms. New Index (SL), equal to 2.70 × CCMwt/1.1414SL, was developed to identify animals of biologically high CCMwt in relation to their SL. New Index (SL) is very similar to the Clean Cashmere Staple Length Index (CCSLI) that had been previously reported for comparison of cashmere goats across farms, and thus the CCSLI can be usefully used for comparing the biological efficiency of cashmere goats both across and within farms. New Index MFD, SL = 8.90 × CCMwt/1.243(MFD+SL)/2 was developed to identify animals of biologically high CCMwt in relation to both their MFD and SL within farms, and provides useful information above using either New Index (MFD) or CCSLI. The indices can be presented in the same measurement units as fleece weight, which is a biological concept easily understood by cashmere producers, and enable comparisons to be made between animals using just one attribute, clean cashmere weight

Comment on "Valence QCD: Connecting QCD to the Quark Model"

I criticize certain conclusions about the physics of hadrons drawn from a "valence QCD" approximation to QCD.Comment: 12 pages, 8 figures; some minor improvements made to the tex

Previously Claimed(/Unclaimed) X-ray Emission Lines in High Resolution Afterglow Spectra

We review the significance determination for emission lines in the Chandra HETGS spectrum for GRB020813, and we report on a search for additional lines in high resolution Chandra spectra. No previously unclaimed features are found. We also discuss the significance of lines sets reportedly discovered using XMM data for GRB011211 and GRB030227. We find that these features are likely of modest, though not negligible, significance.Comment: 4 pages, 1 figures, to appear in Santa Fe GRB Conference Proceedings, 200