Placental expression of inflammatory Galectin-12 is associated with gestational diabetes

Objectives Gestational diabetes mellitus (GDM) is a growing health concern. Since members of the galectin-family are identified to play a role in the pathogenesis of GDM, we determined galectin-12 as an essential protein due to its influence in lipolysis and inflammation processes. This study investigates the expression of galectin-12 in the placentas of women with GDM. Study design The study population includes 40 expectant women suffering from GDM and 40 healthy controls. The expression of galectin-12 in the syncytiotrophoblast (SCT) and the extra villous trophoblast (EVT) of the placenta was analyzed by immunohistological staining and double immunofluorescence. Immunoreactivity Score (IRS) was used for evaluation. Results The results demonstrate a significant overexpression of galectin-12 in the nucleus of the SCT and the EVT of placentas with GDM compared to the healthy control group. Additionally, double immunofluorescence visualizes corresponding results with an overexpression of galectin-12 in the extra villous trophoblast of GDM placentas representing maternal cells. Conclusion This study identifies galectin-12 to be associated with the process of gestational diabetes mellitus. These findings are in correspondence with the involvement of galectin-12 in inflammatory processes. Maternal BMI and male sex seem to be confounder for the expression of galectin-12 in the nuclear syncytiotrophoblast, but not in other parts of the investigated placental areas. Further investigations are necessary to verify the correlation between gestational diabetes mellitus and the expression of galectin-12 in the placenta and to further elucidate its distinct role

Toolbox für die Gründung von Primärversorgungseinheiten (PVE)

Diese Toolbox soll Gründer:innen von Primärversorgungseinheiten in Österreich dabei unterstützen, die notwendigen gesetzlichen und regulatorischen Anforderungen in der Gründungsphase zu adressieren

Weiterbildung weiter denken in den gehobenen medizinisch-technischen Gesundheitsberufen

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Zukunftsperspektiven der medizinisch-technischen Dienste im Fokus Weiterbildung

11. Forschungsforum der Österreichischen FachhochschulenGesundhei

Status quo der akademischen Weiterbildung für Gesundheitsberufe aus dem MTD-Bereich

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Galectin-10 Expression in Placentas of Women with Gestational Diabetes

Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings

Some practical suggestions for improving engagement between researchers and policy-makers in natural resource management

Policy-makers and managers in natural resource management (NRM) often complain that researchers are out of touch. Researchers often complain that policy-makers and managers make poorly informed decisions. In this article, we report on a meeting between researchers, policy-makers and managers convened to identify practical solutions to improve engagement between these camps. A necessary starting point is that every researcher and policy-maker should understand, and tap into, the motivations and reward systems of the other when seeking engagement. For example, researchers can be motivated to engage in policy development if there is a promise of outputs that align with their reward systems such as co-authored publications. Successful research-policy partnerships are built around personal relationships. As a researcher, you cannot therefore expect your results to inform policy by only publishing in journals. As a policy-maker, you cannot guarantee engagement from researchers by publicly inviting comment on a document. Actively building and maintaining relationships with key individuals through discussions, meetings, workshops or field days will increase the likelihood that research outcomes will inform policy decisions. We identified secondments, sabbaticals, fellowships and 'buddies', an annual national NRM conference and 'contact mapping' (a Facebook-type network) as forums that can catalyse new relationships between researchers and policy-makers. We challenge every researcher, policy-maker and manager in NRM to build one new cross-cultural relationship each year