Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response

Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect. Pipamperone acts as a highly selective 5-HT<sub>2A</sub>/D<sub>4</sub> antagonist when administered in low doses. The purpose of this study was to compare citalopram 40 mg once daily plus pipamperone 5 mg twice daily (PipCit) versus citalopram plus placebo twice daily for magnitude and onset of therapeutic effect. Method: An 8-week, randomized, double-blind study in patients with major depressive disorder was carried out. Results: The study population comprised 165 patients (citalopram and placebo, n=82; PipCit, n=83) with a mean baseline Montgomery–Asberg Depression Rating Scale (MADRS) score of 32.6 (S.D.=5.5). In the first 4 weeks, more citalopram and placebo than PipCit patients discontinued treatment (18% v. 4%, respectively, p=0.003). PipCit patients had significantly greater improvement in MADRS score at week 1 [observed cases (OC), p=0.021; last observation carried forward (LOCF), p=0.007] and week 4 (LOCF, p=0.025) but not at week 8 compared with citalopram and placebo patients. Significant differences in MADRS scores favoured PipCit in reduced sleep, reduced appetite, concentration difficulties and pessimistic thoughts. Mean Clinical Global Impression–Improvement scores were significantly improved after 1 week of PipCit compared with citalopram and placebo (OC and LOCF, p=0.002). Conclusions: Although the MADRS score from baseline to 8 weeks did not differ between groups, PipCit provided superior antidepressant effects and fewer discontinuations compared with citalopram and placebo during the first 4 weeks of treatment, especially in the first week

Spectrokinetic studies of two 6,6a-dihydrochromeno(3,4-b) chromene derivatives

Benzo and Naphthopyrans (chromenes) have been extensively studied since the discovery of photochromic reaction of 2H-1-benzopyrans in 1966 by Becker and Michl. Researchers have investigated chromenes for their use in sunglass lenses and also other potential applications such as optical memories and optical switches. Femto/picosecond and nano/microsecond experiments were released on two 6,6a-dihydrochromeno(3,4-b)chromene derivatives. After disappearance of the singlet state S1 formed from each compound, photoproducts with short lifetime (2.2 to 21 ?s) obtained were attributed to the open forms. Keywords: 6,6a-dihydrochromeno(3,4-b)chromene, photochromic, nano/microsecond domain, femto/picosecond domain, wavelength, lifetime.

Étude par absorption transitoire de naphtopyranes liés à des oligothiophènes par différents types de jonctions

LILLE1-BU (590092102) / SudocSudocFranceF

in Aqueous Solution from Picosecond Transient Absorption Measurements

molecule

Étude des propriétés photophysiques de thiocétones et leurs dérivés en solution par spectroscopies électronique et vibrationelle résolues dans le temps

Les propriétés photophysiques d'une thiocétone aromatique modèle, la benzopyranthione (BPT), ont été étudiées par absorption transitoire et spectroscopie d'émission dans différents solvants tels que les alcanes, l' acétonitrile et l'eau. Les propriétés du second état excité singulet S2 ont été particulièrement analysées. Les processus de relaxation vibrationnelle de l'état S2 ont été étudiés dans les alcanes. Par ailleurs, un déclin réorientationnel d'anisotropie a été mis en évidence pour l'état S2. La nature du processus responsable de la désactivation intermoléculaire de l'état S2 a également fait l'objet d'une étude. L'analyse structurale d'un isomère de BPT, la thiocoumarine, à l'état fondamental (S0) et à l'état triplet (T1) a été réalisée par spectroscopie Raman et calculs ab initio. En passant de l'état S0à l'état T1, le noyau benzénique n'est que très légèrement modifié et garde son caractère aromatique, de plus fortes distorsions apparaissant sur la partie pyranthione.LILLE1-BU (590092102) / SudocSudocFranceF