Summary of zebrafish AHR ligand binding, activity and expression.

<p>Summary of zebrafish AHR ligand binding, activity and expression.</p

Fin and skeletal abnormalities observed in adult <i>ahr2</i>^hu3335 zebrafish.

<p><b>A–B</b>) Brightfield and (<b>C–D</b>) microCt imaging of adult <i>ahr2</i>⁺ and <i>ahr2</i>^hu3335zebrafish. Notable differences were observed in the dentate (d), premaxilla (pm), maxilla (mx), supraorbital (so), infraorbital 3(inf) and operculum (op).</p

Primer sequences for PCR experiments.

<p><b>mo</b>- morpholino mis-splice detection.</p><p><b>mut</b>- mutant point mutation detection.</p

MMA enhances <i>P</i>. <i>aeruginosa</i> induced immune response.

<p>Cytokine secretion by HBEC exposed to MMA^III ± <i>P</i>. <i>aeruginosa</i>. n = 4 donors for each treatment. Different letters indicate statistically significant treatment means. Data labeled a are not statistically different from each other but are statistically different from data labeled b or c (p<0.05 as measured by one-way ANOVA). Data with the same letter are not significantly different. (A) IL-8 secretion (B) IL-6 secretion (C) CXCL1 secretion (D) CXCL2 secretion.</p

A combination of iAs^III, MMA^III and DMA^V reduced <i>P</i>. <i>aeruginosa</i> stimulated cytokine secretion.

<p>Cytokine secretion by HBEC exposed to 5 ppb total arsenic (combination of 1.25 ppb iAs^III + 1.25 ppb MMA^III + 2.5 ppb DMA^V) ± <i>P</i>. <i>aeruginosa</i> or 10 ppb total arsenic (combination of 2.5 ppb iAs^III + 2.5 ppb MMA^III + 5 ppb DMA^V) ± <i>P</i>. <i>aeruginosa</i>. n = 4 donors for each treatment. *p = <0.05 for the indicated comparisons. (A) IL-8 secretion (B) IL-6 secretion (C) CXCL1 secretion (D) CXCL2 secretion.</p