A computational model of aesthetic value

People constantly evaluate what they see, and these evaluations determine their choices from small (Where do I look next?) to large (Where do I want to live?). The pleasure associated with a sensory experience, namely its aesthetic value, is perhaps the most frequent and important evaluation. Yet, we have a poor understanding of how sensory experiences gain aesthetic value. We propose a model of aesthetic value that is based on the premise that observers maintain and adapt the states of their cognitive-sensory system in a way that allows them to process stimuli effectively in both the present and the future. Two interlinked components generate value: stimulus processing fluency and the change in fluency with regard to likely future stimuli. In our model, processing fluency is quantified precisely as the likelihood of the stimulus given an observer's state and constitutes immediate sensory reward. The change in fluency with which likely future stimuli will be processed, quantified by the change in the average likelihood of expected future stimuli, constitutes the reward of learning. Simulations show that a simple version of our model can account for empirical data on the effects of exposure, complexity, and symmetry on aesthetic value judgments. Its application offers insight as to how mechanisms that improve long-term processing efficiency give rise to aesthetic value judgments

Discounting the effect of memory on repeated measures of beauty judgment

The intrinsic variance of beauty judgment is key to modeling beauty ratings. However, in repeated measures of beauty, observers surely make use of what they remember. To test how memory contributes to repeated beauty ratings, we asked participants to rate 75 arbitrarily named images (e.g., Fred). Initially, participants rated (1 to 7) how much beauty they felt from looking at a named image. Then participants completed two conditions. In the memory condition, participants saw only the name of an image and were asked to remember the image corresponding to that name and rate how much beauty they felt. In the repeat condition, they once again rated how much beauty they felt from looking at a named image. Lastly, in a memory check, participants tried to select which image was associated with a name. Only considering the correctly remembered trials (60%), we calculated the distribution of the differences between the initial beauty rating and that from either the memory condition or the repeat condition. The variance for the memory condition was more than double that of the repeat condition. Likewise, the initial beauty ratings predicted 84% of the variance in the repeat ratings but only 30% of the variance in the memory ratings. Cue combination studies report that observers typically combine cues by the optimal Bayesian rule: The combined reliability is the sum of the separate reliabilities for each cue, where reliability is one over variance. Assuming optimal combination of memory and immediate-perception judgment, we can discount the contribution of memory to estimate the variance of the immediate-perception judgment. Thus, in our paradigm the 0.83 variance of the repeated beauty rating corresponds to a 0.97 immediate-perception judgment variance (without memory). Overall, since there also was no significant difference in means, our results indicate that memory contributes little to repeated beauty ratings

Beam Scraping to detect and remove Halo in LHC Injection

Fast scrapers are installed in the SPS to detect and remove beam halo before extraction of beams to the LHC, to minimize the probability for quenching of superconducting magnets in the LHC. We shortly describe the current system and then focus on our recent work, which aims at providing a system which can be used as operational tool for standard LHC injection. A new control application was written and tested with the beam. We describe the current status and results and compare these with detailed simulations

A Comparative Survey of Leguminous Plants as Sources of the Isoflavones, Genistein and Daidzein: Implications for Human Nutrition and Health

Over 80 taxa of mostly agriculturally important legumes were surveyed as sources of the metabolites, genistein and daidzein. Remarkably high concentrations (over 2 g · kg–1 dry weight) of the anticancer metabolite, genistein, were found in the leaves of Psoralea corylifolia (Indian bread root). All other legumes, with the exception of fermented soybean miso, had genistein levels <400 mg · kg–1 dry weight. Concentrations of over 1 g · kg–1 dry weight and 0.95 g · kg–1 dry weight of the anticancer metabolite, daidzein, were found in the stems of the fava bean (Vicia faba) and roots of kudzu vine (Pueraria lobata)' respectively. From this survey, our results indicate that the legumes, lupine (Lupinus spp.), fava bean, (Vicia faha), soybeans (Glycine max), kudzu (Pueraria lobata), and psoralea (Psoralea corylifolia), are excellent food sources for both genistein and daidzein. Miso, a fermented soybean product, is also a rich source of both isoflavones.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63131/1/acm.1997.3.7.pd

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease.This work was supported by Fundação para a Ciência e Tecnologia (FCT) and COMPETE through the projects ‘[PTDC/SAU-GMG/112617/2009] (to P.M.) and [EXPL/ BIM-MEC/0239/2012] (to A.T.C.)’, by National Ataxia foundation (to P.M.), by Ataxia UK (to P.M.), by National Institutes of Health (NIH) ‘[GM038109, GM081192, AG026647, and NS047331] (to R.I.M.)’, by The Chicago Biomedical Consortium (to R.I.M.) and by the Ellison Medical Foundation (to R.I.M.). A.T.C., A.J., S.E., L.S.S., C.B., S.D.S., A.S.F. and A.N.C. were supported by the FCT individual fellowships SFRH/BPD/79469/2011, SFRH/BD/76613/2011, SFRH/BD/78554/2011, SFRH/BD/ 84650/2012, SFRH/BPD/74452/2010, SFRH/BD/78388/ 2011, SFRH/BPD/91562/2012 and SFRH/BD/51059/2010, respectively. FCT fellowships are co-financed by POPH, QREN, Governo da República Portuguesa and EU/FSE.info:eu-repo/semantics/publishedVersio

Occurrence and levels of micropollutants across environmental and engineered compartments in Austria

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Among PFAAs and metals, highest concentrations were recorded either in atmospheric deposition or in discharges from wastewater treatment plants. The relevance of the analysis across compartments is best shown by the case of perfluorooctanesulfonic acid (PFOS). Despite municipal wastewater effluents being the emission pathway with highest concentrations, this study reveals that not only rivers, but also atmospheric deposition and groundwater sometimes exceed the environmental quality standard for surface waters. Moreover, this work reveals partially counterintuitive patterns. In rivers with treated wastewater discharges, increasing levels of dissolved compounds were measured at rising flow conditions, whereas the opposite would be expected owing to the dilution effect. This might derive from the mobilisation from soil or suspended particulate matter or rather find its explanation in high concentrations in atmospheric deposition. These hypotheses require however being tested through targeted studies. Additional future research includes the analysis of how regional or catchment specific characteristics might alter the relative importance of different emission pathways, and the modelling of emission and river loads to assess their relative contribution to river pollution.Federal Ministry of Sustainability and Tourism (BMNT)6366531