Multivariate Analysis: Predictors of Six Month Viral Suppression After Change to Second-Line ART in a Cohort of HIV-Infected Children Failing 1^st line ART in Durban, South Africa.

<p>Multivariate Analysis: Predictors of Six Month Viral Suppression After Change to Second-Line ART in a Cohort of HIV-Infected Children Failing 1^st line ART in Durban, South Africa.</p

Univariate Analysis: Predictors of Six Month Viral Suppression After Change to Second-Line ART in a Cohort of HIV-Infected Children Failing 1^st Line ART in Durban, South Africa.

<p>Univariate Analysis: Predictors of Six Month Viral Suppression After Change to Second-Line ART in a Cohort of HIV-Infected Children Failing 1^st Line ART in Durban, South Africa.</p

Baseline Clinical and Demographics Characteristics of A Cohort of HIV-Infected Children Failing 1^st Line ART in Durban, South Africa Stratified by Initial Treatment Regimen and Presence of Resistance Testing.

<p>Baseline Clinical and Demographics Characteristics of A Cohort of HIV-Infected Children Failing 1^st Line ART in Durban, South Africa Stratified by Initial Treatment Regimen and Presence of Resistance Testing.</p

The gender-stratified Kaplan-Meier graph of survival after ART initiation.

<p>The gender-stratified Kaplan-Meier graph of survival after ART initiation.</p

Adjusted Cox Proportional Hazard Ratios for Mortality after Initiating HIV Treatment.

†<p><i>Weight-for-age Z-score</i> and <i>Female*ln time</i> were treated as continuous variables. Reference groups for the binary variables include: <i>Age <3 years</i> – reference age 3–18 years; <i>CD4 <10%</i> - reference CD4 >10%; <i>chronic diarrhea</i> – reference children not documented to have chronic diarrhea.</p><p>*13 subjects were missing one or more of the model's predictor variables and were not included in the analysis.</p>‡<p><i>Female*ln time</i> represents the interaction term of female gender and the natural log of time in weeks since ART initiation.</p

The age-stratified Kaplan-Meier graph of survival after ART initiation.

<p>The age-stratified Kaplan-Meier graph of survival after ART initiation.</p

Demographic and Clinical Characteristics.

<p>*20 children in the <3 year old group were started on NNRTI while all children over 3 years old were initiated on NNRTI based treatment.</p>†<p>WHO weight-for-age Z-score is only valid for children <10 years old.</p

Unadjusted Cox Proportional Hazard Ratios for Mortality after Initiating HIV Treatment.

†<p><i>Absolute CD4, hemoglobin</i> and <i>weight-for-age Z-score</i> were treated as continuous variables. Reference groups for the binary variables include: <i>Age <3 years</i> – reference age 3–18 years; <i>CD4 <10%</i> - reference CD4 >10%, <i>Opportunistic infection</i> includes children with the presence of candidiasis, Kaposi's sarcoma, Pneumocystis jiroveci pneumonia, cryptococcosis, toxoplasmosis, or cryptosporidiosis, while the reference group did not have any of these opportunistic infections; <i>Tuberculosis at or after initiation or HIV therapy</i> – reference was the absence of HIV-tuberculosis co-infection; <i>chronic diarrhea</i> – reference children not documented to have chronic diarrhea.</p

Characteristics of adolescents and young adults aged 13 to 24 years receiving antiretroviral therapy and attending an adolescent-friendly clinic or standard pediatric clinic from April 2007 to November 2015 in KwaZulu-Natal, South Africa.

<p>Characteristics of adolescents and young adults aged 13 to 24 years receiving antiretroviral therapy and attending an adolescent-friendly clinic or standard pediatric clinic from April 2007 to November 2015 in KwaZulu-Natal, South Africa.</p

Baseline Clinical and Demographic Characteristics of a Cohort of HIV-infected <10 Years Old Children Initiating ART, by CD4 Availability at Six and 12 months, South Africa, August 2003–December 2008.

<p>*Children less than 3 years are started on a PI-based regimen while children over 3 years are started on an NNRTI-based regimen.</p>†<p>Baseline tuberculosis co-infection.</p>‡<p><i>Opportunistic infection</i> includes children with the presence of candidiasis, Kaposi's sarcoma, Pneumocystis jiroveci pneumonia, cryptococcosis, toxoplasmosis, or cryptosporidiosis.</p