Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Performance of a Generic Approach in Automated Essay Scoring

A generic approach in automated essay scoring produces scores that have the same meaning across all prompts, existing or new, of a writing assessment. This is accomplished by using a single set of linguistic indicators (or features), a consistent way of combining and weighting these features into essay scores, and a focus on features that are not based on prompt-specific information or vocabulary. This approach has both logistical and validity-related advantages. This paper evaluates the performance of generic scores in the context of the e-rater® automated essay scoring system. Generic scores were compared with prompt-specific scores and scores that included prompt-specific vocabulary features. These comparisons were performed with large samples of essays written to three writing assessments: The GRE General Test argument and issue tasks and the TOEFL independent task. Criteria for evaluation included level of agreement with human scores, discrepancy from human scores across prompts, and correlations with other available scores. Results showed small differences between generic and prompt-specific scores and adequate performance of both types of scores compared to human performance