Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium

Monocytes are abundant immune cells that infiltrate inflamed organs. However, the majority of monocyte studies focus on circulating cells, rather than those in tissue. Here, we identify and characterize an intravascular synovial monocyte population resembling circulating non-classical monocytes and an extravascular tissue-resident monocyte-lineage cell (TR-MC) population distinct in surface marker and transcriptional profile from circulating monocytes, dendritic cells, and tissue macrophages that are conserved in rheumatoid arthritis (RA) patients. TR-MCs are independent of NR4A1 and CCR2, long lived, and embryonically derived. TR-MCs undergo increased proliferation and reverse diapedesis dependent on LFA1 in response to arthrogenic stimuli and are required for the development of RA-like disease. Moreover, pathways that are activated in TR-MCs at the peak of arthritis overlap with those that are downregulated in LFA1-/- TR-MCs. These findings show a facet of mononuclear cell biology that could be imperative to understanding tissue-resident myeloid cell function in RA.</p

Fascial space infection patients reporting to Department of Oral and Maxillofacial Surgery at Dasmesh Institute of Research and Dental Sciences, Faridkot: A retrospective study

Aim: This aim of this study is being conducted to assess the incidence of fascial space infection and its management in patients presenting to department of Oral and Maxillofacial Surgery at Dasmesh Institute of Research and Dental Sciences, Faridkot. Methods: This retrospective study was done the in the Department of Oral and Maxillofacial Surgery Dasmesh Institute of Research and Dental Sciences, Faridkot, India, from January 2015 to December 2020. Total 84 fascial space infection record of previous five year patients (reporting to Department of Oral and Maxillofacial Surgery was evaluated. Patients reported with fascial space infection with age group from 16-70 yrs and ASA I &amp; I were included in this study. Results: The age group most commonly involved was in the third and fourth decades of life. The mean age group was 33.55. Males (55.95%) were more commonly involved than females (44.05%)

Fascial space infection patients reporting to department of oral and maxillofacial surgery at Dasmesh Institute of Research and Dental Sciences, Faridkot: A retrospective study

This aim of this study is being conducted to assess the incidence of fascial space infection and its management in patients presenting to department of Oral and Maxillofacial Surgery at Dasmesh Institute of Research and Dental Sciences, Faridkot. This retrospective study was done the in the Department of Oral and Maxillofacial Surgery Dasmesh Institute of Research and Dental Sciences, Faridkot, India, from January 2015 to December 2020. Total 84 fascial space infection record of previous five year patients (reporting to Department of Oral and Maxillofacial Surgery was evaluated. Patients reported with fascial space infection with age group from 16-70 yrs and ASA I &amp; I were included in this study. The age group most commonly involved was in the third and fourth decades of life. The mean age group was 33.55. Males (55.95%) were more commonly involved than females (44.05%). The most commonly involved space was Right submandibular space infection (17.86%) followed by left submandibular space infection 15.48, R buccal space infection (9.52%), Left buccal space infection (7.14%), Right infraorbital space infection (7.14%), Left pterygomandibular space infection (7.14%),Space infection wrt left submandibular space, submental space, left sublingual space(5.95%), Masticatory space infection with impending submandibular + submental cellulitis (5.95%)