580 research outputs found
Adsorption of a binary mixture of monomers with nearest-neighbour cooperative effects
A model for the adsorption of a binary mixture on a one-dimensional infinite
lattice with nearest neighbour cooperative effects is considered. The particles
of the two species are both monomers but differ in the repulsive interaction
experienced by them when trying to adsorb. An exact expression for the coverage
of the lattice is derived. In the jamming limit, it is a monotonic function of
the ratio between the attempt frequencies of the two species, varying between
the values corresponding to each of the two single species. This is in contrast
with the results obtained in other models for the adsorption of particles of
different sizes. The structure of the jamming state is also investigated.Comment: v2: Errors in the figures fixed; same text; 23 pages, 5 figures.
Accepted for publication in Journal of Physics A: Mathematical and Genera
Random sequential adsorption on a dashed line
We study analytically and numerically a model of random sequential adsorption
(RSA) of segments on a line, subject to some constraints suggested by two kinds
of physical situations:
- deposition of dimers on a lattice where the sites have a spatial extension;
- deposition of extended particles which must overlap one (or several)
adsorbing sites on the substrate.
Both systems involve discrete and continuous degrees of freedom, and, in one
dimension, are equivalent to our model, which depends on one length parameter.
When this parameter is varied, the model interpolates between a variety of
known situations : monomers on a lattice, "car-parking" problem, dimers on a
lattice. An analysis of the long-time behaviour of the coverage as a function
of the parameter exhibits an anomalous 1/t^2 approach to the jamming limit at
the transition point between the fast exponential kinetics, characteristic of
the lattice model, and the 1/t law of the continuous one.Comment: 14 pages (Latex) + 4 Postscript figure
Irreversible Deposition of Line Segment Mixtures on a Square Lattice: Monte Carlo Study
We have studied kinetics of random sequential adsorption of mixtures on a
square lattice using Monte Carlo method. Mixtures of linear short segments and
long segments were deposited with the probability and , respectively.
For fixed lengths of each segment in the mixture, the jamming limits decrease
when increases. The jamming limits of mixtures always are greater than
those of the pure short- or long-segment deposition.
For fixed and fixed length of the short segments, the jamming limits have
a maximum when the length of the long segment increases. We conjectured a
kinetic equation for the jamming coverage based on the data fitting.Comment: 7 pages, latex, 5 postscript figure
Adsorption of Line Segments on a Square Lattice
We study the deposition of line segments on a two-dimensional square lattice.
The estimates for the coverage at jamming obtained by Monte-Carlo simulations
and by -order time-series expansion are successfully compared. The
non-trivial limit of adsorption of infinitely long segments is studied, and the
lattice coverage is consistently obtained using these two approaches.Comment: 19 pages in Latex+5 postscript files sent upon request ; PTB93_
A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation.
INTRODUCTION: The existence of partial volume effects in brain MR images makes it challenging to understand physio-pathological alterations underlying signal changes due to pathology across groups of healthy subjects and patients. In this study, we implement a new approach to disentangle gray and white matter alterations in the thalamus and the basal ganglia. The proposed method was applied to a cohort of early multiple sclerosis (MS) patients and healthy subjects to evaluate tissue-specific alterations related to diffuse inflammatory or neurodegenerative processes.
METHOD: Forty-three relapsing-remitting MS patients and nineteen healthy controls underwent 3T MRI including: (i) fluid-attenuated inversion recovery, double inversion recovery, magnetization-prepared gradient echo for lesion count, and (ii) T1 relaxometry. We applied a partial volume estimation algorithm to T1 relaxometry maps to gray and white matter local concentrations as well as T1 values characteristic of gray and white matter in the thalamus and the basal ganglia. Statistical tests were performed to compare groups in terms of both global T1 values, tissue characteristic T1 values, and tissue concentrations.
RESULTS: Significant increases in global T1 values were observed in the thalamus (p = 0.038) and the putamen (p = 0.026) in RRMS patients compared to HC. In the Thalamus, the T1 increase was associated with a significant increase in gray matter characteristic T1 (p = 0.0016) with no significant effect in white matter.
CONCLUSION: The presented methodology provides additional information to standard MR signal averaging approaches that holds promise to identify the presence and nature of diffuse pathology in neuro-inflammatory and neurodegenerative diseases
Jamming coverage in competitive random sequential adsorption of binary mixture
We propose a generalized car parking problem where cars of two different
sizes are sequentially parked on a line with a given probability . The free
parameter interpolates between the classical car parking problem of only
one car size and the competitive random sequential adsorption (CRSA) of a
binary mixture. We give an exact solution to the CRSA rate equations and find
that the final coverage, the jamming limit, of the line is always larger for a
binary mixture than for the uni-sized case. The analytical results are in good
agreement with our direct numerical simulations of the problem.Comment: 4 pages 2-column RevTeX, Four figures, (there was an error in the
previous version. We replaced it (including figures) with corrected and
improved version that lead to new results and conclusions
Critical Behavior of the Ferromagnetic Ising Model on a Sierpinski Carpet: Monte Carlo Renormalization Group Study
We perform a Monte Carlo Renormalization Group analysis of the critical
behavior of the ferromagnetic Ising model on a Sierpi\'nski fractal with
Hausdorff dimension . This method is shown to be relevant to
the calculation of the critical temperature and the magnetic
eigen-exponent on such structures. On the other hand, scaling corrections
hinder the calculation of the temperature eigen-exponent . At last, the
results are shown to be consistent with a finite size scaling analysis.Comment: 16 pages, 7 figure
Absence of beneficial effect of intravenous metoprolol given during angioplasty in patients with single-vessel coronary artery disease
In a double-blind, randomized, placebo-controlled trial, the possible antiischemic effect of metoprolol during percutaneous transluminal coronary angioplasty was tested. Electrocardiograms, hemodynamics, and metabolism were studied in 27 patients with a stenosis in the left anterior descending coronary artery. Measurements took place before angioplasty, after each of four 1-minute occlusions and 15 minutes after the last balloon deflation. Patients were randomly given placebo or metoprolol (15 mg as a bolus intravenously, followed by an infusion 0.04 mg/kg/hr). At the end of the procedure, the rate-pressure product had decreased by 15% (NS) and 23% (p=0.001) in the placebo and metoprolol groups, respectively, mainly due to similar decreases in heart rate. Metoprolol tended to lower chest pain and reduce precordial ST-segment elevation due to angioplasty, but the effects were not statistically significant. Lactate, hypoxanthine, and urate release immediately after deflation was similar in both groups. Metoprolol reduced arterial plasma hypoxanthine throughout the procedure by about 30% (p ≦ 0.02 vs. placebo). Thus, intravenous infusion of metoprolol did not significantly attenuate chest pain and ST-segment elevation, and failed to decrease cardiac lactate and oxypurine release. It did, however, reduce arterial hypoxanthine concentrations during angioplasty, possibly indicating that the beta-blocker inhibits extracardiac ATP catabolism.
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MP2RAGE provides new clinically-compatible correlates of mild cognitive deficits in relapsing-remitting multiple sclerosis.
Despite that cognitive impairment is a known early feature present in multiple sclerosis (MS) patients, the biological substrate of cognitive deficits in MS remains elusive. In this study, we assessed whether T1 relaxometry, as obtained in clinically acceptable scan times by the recent Magnetization Prepared 2 Rapid Acquisition Gradient Echoes (MP2RAGE) sequence, may help identifying the structural correlate of cognitive deficits in relapsing-remitting MS patients (RRMS). Twenty-nine healthy controls (HC) and forty-nine RRMS patients underwent high-resolution 3T magnetic resonance imaging to obtain optimal cortical lesion (CL) and white matter lesion (WML) count/volume and T1 relaxation times. T1 z scores were then obtained between T1 relaxation times in lesion and the corresponding HC tissue. Patient cognitive performance was tested using the Brief Repeatable Battery of Neuro-psychological Tests. Multivariate analysis was applied to assess the contribution of MRI variables (T1 z scores, lesion count/volume) to cognition in patients and Bonferroni correction was applied for multiple comparison. T1 z scores were higher in WML (p < 0.001) and CL-I (p < 0.01) than in the corresponding normal-appearing tissue in patients, indicating relative microstructural loss. (1) T1 z scores in CL-I (p = 0.01) and the number of CL-II (p = 0.04) were predictors of long-term memory; (2) T1 z scores in CL-I (β = 0.3; p = 0.03) were independent determinants of long-term memory storage, and (3) lesion volume did not significantly influenced cognitive performances in patients. Our study supports evidence that T1 relaxometry from MP2RAGE provides information about microstructural properties in CL and WML and improves correlation with cognition in RRMS patients, compared to conventional measures of disease burden
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