Digital twin for tool wear monitoring and compensation in turning

In mass production of manufactured goods using conventional milling and turning, tool wear is reflected in the drift of quality control measurements. Methods have been developed to correct this drift and compensate the wear. With the possibilities offered by the digital twin concept, a new method of tool wear compensation was proposed including a digital twin of the tool and a digital twin of the lathe, based on the measurements of the parts. This digital twin solution provides useful functionalities such as a heritage process between the digital twin of old tools and the one of the tool being used.Interreg EMR Digital Twin Academy12. Responsible consumption and productio

Identifying a problem and solving it with a digital twin idea

Interreg EMR Digital Twin Academ

CRISPR-Cas Systems Impact Pseudomonas aeruginosa Genome Structure

<i>Pseudomonas aeruginosa</i> is both an antibiotic-resistant opportunistic pathogen and an important model of type I clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR-Cas) systems. Comparative genomics has identified several CRISPR-Cas subtypes, and it was previously unclear how these immune modules might influence the genome content of <i>P. aeruginosa</i>. To better understand the distribution of CRISPR-Cas subtypes and their impact on genome composition, we annotated 672 <i>P. aeruginosa</i> clinical isolates. We found that CRISPR-Cas systems modulate genome size and accessory elements. In addition, we identified a novel, putatively mobile type I-C CRISPR-Cas system. In the process, we also created a global spacer library that provides a new means of identifying accessory fragments, and facilitates CRISPR typing of many <i>P. aeruginosa</i> strains. Finally, we have made the assemblies of 282 newly-sequenced <i>P. aeruginosa</i> isolates public as an NCBI BioProject (ID: PRJNA297679)