3 research outputs found
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
- Author
- Assenov Yassen
- Baier Gerald
- Becher Heiko
- Bermejo Justo L.
- Bogatyrova Olga
- Bohrer Manfred H.
- Boukamp Petra
- Chaisaingmongkol Jittiporn
- Chan Tsun L.
- Delank Klaus W.
- Dietz Andreas
- Dyckhoff Gerhard
- Herold-Mende Christel
- Heyny-von Haußen Roland
- Hörmann Karl
- Kaucher Simone
- Kuhmann Christine
- Lasitschka Felix
- Leung Suet Y.
- Lippert Burkhard M.
- Marx Alexander
- Oakes Christopher C.
- Plass Christoph
- Popanda Odilia
- Ramroth Heribert
- Santi Irene
- Schmezer Peter
- Weigel Christoph
- Winkler Volker
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2019
- Field of study
Background: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).
Results: Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both patient cohorts (p = 0.016 and < 0.001, respectively) and in 15 out of 22 TCGA studies. Methylation loss correlated with immunohistochemically staining for TREX2 (p < 0.0001) in laryngeal tumors and improved overall survival of laryngeal cancer patients (p = 0.045). Chromatin immunoprecipitation, demethylation experiments, and reporter gene assays revealed that the region of methylation loss can function as a CCAAT/enhancer binding protein alpha (CEBPA)-responsive enhancer element regulating TREX2 expression.
Conclusions: The data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer. Altered TREX2 protein levels in tumors may affect drug-induced DNA damage repair and provide new tailored therapies
Correlation between neovascularisation and neuroendocrine differentiation in prostatic carcinoma
- Author
- Abrahamsson
- Allen
- Aprikian
- Aprikian
- Bohrer
- Bohrer
- Bohrer
- Bonkhoff
- Bonkhoff
- Bonkhoff
- Bonkhoff
- Bonkhoff
- Brawer
- Brawer
- Bubendorf
- Casella
- Cohen
- Cohen
- Cohen
- di Sant' Agnese
- di Sant' Agnese
- di Sant'Agnese
- di Sant'Agnese
- Fewer
- Folkman
- Folkman
- Folkman
- Folkman
- Folkman
- Fontanini
- Harper
- Helpap
- Hepburn
- Iwamura
- Klaus-Peter Jünemann
- Lissbrant
- Manfred H. Bohrer
- Matthias Woenckhaus
- McWilliam
- Meyer
- Michael Siegsmund
- Nakada
- Noordzij
- O'Reilly
- Okamoto
- Rainer Grobholz
- Shah
- Uwe Bleyl
- Vartanian
- Weidner
- Weidner
- Weidner
- Weinstein
- Woenckhaus
- Wright
- Xue
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Literaturverzeichnis
- Author
- Adelung
- Almond Mark
- Ameluxen Andrei Ujica
- Anders Günther
- Anders Günther
- Anders Günther
- Anz Spannung
- Assmann Aleida
- Assmann Aleida
- Assmann Aleida
- Assmann Aleida
- Assmann Aleida
- Assmann Aleida
- Assmann Jan
- Assmann Ute Frevert
- AugØ Marc
- Aust Cord Schnibben
- Aust Stefan
- Baasner Rainer
- Bachtin Michail M
- Bachtin Michail M
- Badiou Alain
- Baier Lothar
- Baier Lothar
- Barthes Roland
- Barthes Roland
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- Baudrillard Amerika
- Baudrillard Amerika
- Baudrillard Amerika
- Baudrillard Amerika
- Baßler Moritz
- Bd
- Bd M.
- Beck Risikogesellschaft
- Beise Arnd
- Benhabib Seyla
- Bentele Günter
- Benthien Hans Rudolf
- Berg Roland
- Berlin S.
- Birgfeld Claude D
- Bohrer
- Bohrer
- Bohrer
- Bolz Norbert
- Bolz Norbert
- Borchmeyer Dieter
- Borst Arno
- Bosse Ulrich A
- Bourdieu Pierre
- Brauburger Oliver
- Brauneck Manfred
- Breitinger
- Bronfen Sigrid Weigel
- Brussig Thomas
- Brückner Christine
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- Buchowetz Marion Jerschowa
- Bude Heinz
- Burgess Anthony
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- Buselmeier Michael
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- Campe
- Canetti Elias
- Carlyle Thomas
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- Celan Paul
- Celan Paul
- Chiarloni Helga Pankoke
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- Cohn Dorrit
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- Conradt Gerd
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- Deutsche Literatur Eine Sozialgeschichte
- Dikovitskaya Margaret
- Dilthey Wilhelm
- Dirk Göttsche
- Domsich Johannes
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- Draaisma Douwe
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