Criminal victimisation in people with severe mental illness: A multi-site prevalence and incidence survey in the netherlands

Background: Although crime victimisation is as prevalent in psychiatric patients as crime perpetration (and possibly more so), few European figures for it are available. We therefore assessed its one-year prevalence and incident rates in Dutch severely mentally ill outpatients, and compared the results with victimisation rates in the general population. Method: This multisite epidemiological survey included a random sample of 956 adult severe

Reflective arrayed waveguide gratings based on Sagnac loop reflectors with custom spectral response

© 2014 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibitedIn this paper, a model for the analysis and design of a reflective Arrayed Waveguide Grating is presented. The device consists of one half of a regular AWG where each arm waveguide in the array is terminated with a phase shifter and a Sagnac loop reflector. By individually adjusting the phase shifter and Sagnac reflectivity in each arm, additional functionality to that previously reported in the literature is attained, since this enables tailoring the spectral response of the AWG. The design and experimental demonstration of Gaussian pass-band shape devices in Silicon-on-Insulator technology are reported. Methods to obtain flattened and arbitrary spectral responses are described and supported by simulation results. (C) 2014 Optical Society of AmericaThe authors acknowledge financial support by the Spanish MINECO projects TEC2010-21337, TEC2013-42332-P; FEDER UPVOV 10-3E-492 and UPVOV 08-3E-008. B. Gargallo acknowledges financial support through FPI grant BES-2011-046100. The authors thank J.S. Fandino for helpful discussions.Gargallo Jaquotot, BA.; Muñoz Muñoz, P.; Baños López, R.; Giesecke, AL.; Bolten, J.; Wahlbrink, T.; Kleinjans, H. (2014). Reflective arrayed waveguide gratings based on Sagnac loop reflectors with custom spectral response. Optics Express. 22(12):14348-14362. https://doi.org/10.1364/OE.22.014348S14348143622212Brackett, C. A. (1990). Dense wavelength division multiplexing networks: principles and applications. IEEE Journal on Selected Areas in Communications, 8(6), 948-964. doi:10.1109/49.57798Kirchain, R., & Kimerling, L. (2007). A roadmap for nanophotonics. 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Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis

"Background Pathological complete response has been proposed as a surrogate endpoint for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (EFS), and overall survival (OS). We had four key objectives: to establish the association between pathological complete response and EFS and OS, to establish the definition of pathological complete response that correlates best with long-term outcome, to identify the breast cancer subtypes in which pathological complete response is best correlated with long-term outcome, and to assess whether an increase in frequency of pathological complete response between treatment groups predicts improved EFS and OS. Methods We searched PubMed, Embase, and Medline for clinical trials of neoadjuvant treatment of breast cancer. To be eligible, studies had to meet three inclusion criteria: include at least 200 patients with primary breast cancer treated with preoperative chemotherapy followed by surgery; have available data for pathological complete response, EFS, and OS; and have a median follow-up of at least 3 years. We compared the three most commonly used definitions of pathological complete response—ypT0 ypN0, ypT0/is ypN0, and ypT0/is—for their association with EFS and OS in a responder analysis. We assessed the association between pathological complete response and EFS and OS in various subgroups. Finally, we did a trial-level analysis to assess whether pathological complete response could be used as a surrogate endpoint for EFS or OS. Findings We obtained data from 12 identified international trials and 11 955 patients were included in our responder analysis. Eradication of tumour from both breast and lymph nodes (ypT0 ypN0 or ypT0/is ypN0) was better associated with improved EFS (ypT0 ypN0: hazard ratio [HR] 0·44, 95% CI 0·39–0·51; ypT0/is ypN0: 0·48, 0·43–0·54) and OS (0·36, 0·30–0·44; 0·36, 0·31–0·42) than was tumour eradication from the breast alone (ypT0/is; EFS: HR 0·60, 95% CI 0·55–0·66; OS 0·51, 0·45–0·58). We used the ypT0/is ypN0 definition for all subsequent analyses. The association between pathological complete response and long-term outcomes was strongest in patients with triple-negative breast cancer (EFS: HR 0·24, 95% CI 0·18–0·33; OS: 0·16, 0·11–0·25) and in those with HER2-positive, hormone-receptor-negative tumours who received trastuzumab (EFS: 0·15, 0·09–0·27; OS: 0·08, 0·03, 0·22). In the trial-level analysis, we recorded little association between increases in frequency of pathological complete response and EFS (R2=0·03, 95% CI 0·00–0·25) and OS (R2=0·24, 0·00–0·70). Interpretation Patients who attain pathological complete response defined as ypT0 ypN0 or ypT0/is ypN0 have improved survival. The prognostic value is greatest in aggressive tumour subtypes. Our pooled analysis could not validate pathological complete response as a surrogate endpoint for improved EFS and OS. Funding US Food and Drug Administration.