A Quantum Mechanics without Subjective Element

It is not easy for practicing physicists to keep track of the ongoing philosophical debate concerning the "reality'' of the entities they manipulate or the "objective validity'' of the results of their work. In addition, the role of the observer and the theory of the measuring process seem to be themselves controversial. Therefore it may be appropriate to present an interpretation of quantum mechanics which corresponds to the perspective of most practicing physicists, although the author makes no claim to possessing any particular knowledge of the literature in this domain. The final four sections present some more specific descriptions of the concepts used, so that they may also serve for more philosophical discussions

Dissenting Opinions by Supreme Court Justices in Federal Income Tax Controversies

What is to be learned from this review of the various analyses offered in dissenting tax opinions over the past five terms of the Supreme Court? When the Court has decisively interpreted narrow or technical language in the statute, dissenters all too often indulge in lengthy analyses that can only serve to create further confusion. Only when the Court focuses on a judicially made rule or an issue with constitutional implications is a broader dissent appropriate. If dissenters generally adhered to the guidelines set forth at the outset of this Article the tax world would, I believe, be at least marginally better off

The Tax Avoidance Problem in the United States

At the Canadian Tax Foundation\u27s Twelfth Tax Conference, Professor Blum discussed what role the judiciary and the legislature should each play in closing some of the loopholes present in the tax code. Professor Blum argues that the courts should limit themselves to the legislative intent of a particular tax rule to close these loopholes. He then examines what the legislature has done to close loopholes (qualifying certain rules, enacting specific rules as loopholes appear, or attempting comprehensive reform of a specific area of tax law), and ends with an appeal to a reasonable tax law

Public Law Perspectives on a Private Law Problem: Auto Compensation Plans

Professors Blum and Kalven introduce their new work on the theories of tort liability and compensation, using auto accidents as their testing ground. Their work revolves around the policy decisions of auto insurance, how to decide liability for auto accidents, and what private tort law and public welfare law can together say about the issue

Slumlordism as a Tort--A Dissenting View

The persistence of substandard housing in urban centers stands as a challenge to law. There is a pressing need to re-examine whether prevailing legal doctrines are adequate for dealing with the problem and to suggest new doctrines where the old are found wanting. To their great credit, Joseph L. Sax and Fred J. Hiestand in their article Slumlordism as a Tort face up to these tasks boldly and vigorously. They conclude that, under existing conditions, it is imprudent to rely on public authorities to enforce housing codes and it is unlikely that legislatures will place sufficient enforcement powers in private hands. Therefore they seek to locate an avenue by which the courts can put private parties in a position to serve as enforcement agencies. Their solution, as indicated by the title given the article, is to make slumlordism into tortious conduct vis-a-vis tenants

Routes of Ca²⁺ shuttling during Ca²⁺ oscillations FOCUS ON THE ROLE OF MITOCHONDRIAL Ca²⁺ HANDLING AND CYTOSOLIC Ca²⁺ BUFFERS

In some cell types, Ca²⁺ oscillations are strictly dependent on Ca²⁺ influx across the plasma membrane, whereas in others, oscillations also persist in the absence of Ca²⁺ influx. We observed that, in primary mesothelial cells, the plasmalemmal Ca²⁺ influx played a pivotal role. However, when the Ca²⁺ transport across the plasma membrane by the “lanthanum insulation method” was blocked prior to the induction of the serum-induced Ca²⁺ oscillations, mitochondrial Ca²⁺ transport was found to be able to substitute for the plasmalemmal Ca²⁺ exchange function, thus rendering the oscillations independent of extracellular Ca²⁺. However, in a physiological situation, the Ca²⁺-buffering capacity of mitochondria was found not to be essential for Ca²⁺ oscillations. Moreover, brief spontaneous Ca²⁺ changes were observed in the mitochondrial Ca²⁺ concentration without apparent changes in the cytosolic Ca²⁺ concentration, indicating the presence of a mitochondrial autonomous Ca²⁺ signaling mechanism. In the presence of calretinin, a Ca²⁺-buffering protein, the amplitude of cytosolic spikes during oscillations was decreased, and the amount of Ca²⁺ ions taken up by mitochondria was reduced. Thus, the increased calretinin expression observed in mesothelioma cells and in certain colon cancer might be correlated to the increased resistance of these tumor cells to proapoptotic/pronecrotic signals. We identified and characterized (experimentally and by modeling) three Ca²⁺ shuttling pathways in primary mesothelial cells during Ca²⁺ oscillations: Ca²⁺ shuttled between (i) the endoplasmic reticulum (ER) and mitochondria, (ii) the ER and the extracellular space, and (iii) the ER and cytoplasmic Ca²⁺ buffers

Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration

The Ca2+-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin’s likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus might be implicated in mesothelioma formation. To further investigate calretinin’s putative role in the early steps of MM generation, primary mesothelial cells from calretinin knockout (CR−/−) and wildtype (WT) mice were compared. Primary mouse mesothelial cells from WT and CR−/− mice were investigated with respect to morphology, marker proteins, proliferation, cell cycle parameters and mobility in vitro. Overexpression of calretinin or a nuclear-targeted variant was achieved by a lentiviral expression system. CR−/− mice have a normal mesothelium and no striking morphological abnormalities compared to WT animals were noted. Primary mouse mesothelial cells from both genotypes show a typical “cobblestone-like” morphology and express mesothelial markers including mesothelin. In cells from CR−/− mice in vitro, we observed more giant cells and a significantly decreased proliferation rate. Up-regulation of calretinin in mesothelial cells of both genotypes increases the proliferation rate and induces a cobblestone-like epithelial morphology. The length of the S/G2/M phase is unchanged, however the G1 phase is clearly prolonged in CR−/− cells. They are also much slower to close a scratch in a confluent cell layer (2D-wound assay). In addition to a change in cell morphology, an increase in proliferation and mobility is observed, if calretinin overexpression is targeted to the nucleus. Thus, both calretinin and nuclear-targeted calretinin increase mesothelial cell proliferation and consequently, speed up the scratch-closure time. The increased rate of scratch closure in WT cells is the result of two processes: an increased proliferation rate and augmented cell mobility of the border cells migrating towards the empty space. We hypothesize that the differences in proliferation and mobility between WT and CR−/− mesothelial cells are the likely result from differences in their developmental trajectories. The mechanistic understanding of the function of calretinin and its putative implication in signaling pathways in normal mesothelial cells may help understanding its role during the processes that lead to mesothelioma formation and could possibly open new avenues for mesothelioma therapy, either by directly targeting calretinin expression or indirectly by targeting calretinin-mediated downstream signaling